• MeSH
• Radiation, Ionizing classification   MeSH
• Humans MeSH
• Neoplasms * radiotherapy   MeSH
• Radiotherapy * methods   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• MeSH
• Academies and Institutes * history   organization & administration   trends   MeSH
• Biophysics * methods   organization & administration   trends   MeSH
• Information Systems MeSH
• Radiation, Ionizing classification   MeSH
• Humans MeSH
• Decision Support Techniques MeSH
• Education, Medical, Undergraduate methods   organization & administration   trends   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Historical Article MeSH
• Geographicals
• Czech Republic MeSH

Conventional radiotherapy with X- and gamma-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and (12)C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with gamma-rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u (12)C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than gamma-rays. The best efficiency was obtained with (12)C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for (12)C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and (12)C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance.

• MeSH
• Financing, Organized MeSH
• Radiation, Ionizing classification   MeSH
• Humans MeSH
• Melanoma radiotherapy   MeSH
• Cell Line, Tumor radiation effects   MeSH
• Cell Proliferation drug effects   radiation effects   MeSH
• Protons MeSH
• Radiation Effects MeSH
• Heavy Ion Radiotherapy MeSH
• Radiotherapy methods   utilization   MeSH
• Statistics as Topic MeSH
• Heavy Ions MeSH
• Radiation Tolerance radiation effects   MeSH
• Carbon MeSH
• Cell Survival radiation effects   MeSH
• Radiotherapy, High-Energy methods   utilization   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Brachytherapy methods   trends   utilization   MeSH
• Radiation Dosage MeSH
• Dose Fractionation, Radiation MeSH
• Radiation, Ionizing * classification   MeSH
• Combined Modality Therapy methods   trends   utilization   MeSH
• Radiotherapy, Conformal methods   trends   utilization   MeSH
• Humans MeSH
• Linear Energy Transfer MeSH
• Nuclear Medicine methods   trends   MeSH
• Radiotherapy Planning, Computer-Assisted methods   trends   utilization   MeSH
• Radiation Oncology * methods   trends   MeSH
• Radiotherapy, Intensity-Modulated methods   trends   utilization   MeSH
• Radiotherapy * methods   trends   utilization   MeSH
• X-Rays adverse effects   MeSH
• Gamma Rays classification   adverse effects   therapeutic use   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• Keywords
• křivka přežití diploidních buněk, kumulativní biologický účinek při frakcionovaném ozařování,
• MeSH
• Diploidy MeSH
• Cell Fractionation methods   MeSH
• Radiation, Ionizing classification   MeSH
• Medical Oncology methods   MeSH
• Humans MeSH
• Radiobiology * methods   MeSH
• Radiotherapy * methods   utilization   MeSH
• Statistics as Topic MeSH
• Models, Theoretical * MeSH
• Check Tag
• Humans MeSH