- MeSH
- Analgesics administration & dosage adverse effects therapeutic use MeSH
- Antidepressive Agents administration & dosage adverse effects therapeutic use MeSH
- Diphosphonates administration & dosage adverse effects therapeutic use MeSH
- Denosumab administration & dosage adverse effects therapeutic use MeSH
- Diagnostic Imaging methods trends utilization MeSH
- Fractures, Spontaneous * diagnosis etiology MeSH
- Adrenal Cortex Hormones administration & dosage adverse effects therapeutic use MeSH
- Humans MeSH
- Neoplasm Metastasis diagnosis prevention & control MeSH
- Musculoskeletal Pain diagnosis etiology therapy MeSH
- Cancer Pain * diagnosis etiology therapy MeSH
- Bone Neoplasms * diagnosis complications therapy MeSH
- Neoplasms diagnosis complications therapy MeSH
- Antineoplastic Agents administration & dosage adverse effects therapeutic use MeSH
- Radiopharmaceuticals administration & dosage adverse effects therapeutic use MeSH
- Radiotherapy methods adverse effects utilization MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
x
x
- MeSH
- Radiotherapy, Adjuvant methods utilization MeSH
- Radiotherapy Dosage standards MeSH
- Carcinoma diagnosis radiotherapy MeSH
- Cardiotoxicity * complications prevention & control MeSH
- Humans MeSH
- Meta-Analysis as Topic MeSH
- Breast Neoplasms * diagnosis radiotherapy MeSH
- Drug-Related Side Effects and Adverse Reactions complications prevention & control MeSH
- Lung Injury diagnosis etiology prevention & control MeSH
- Proton Therapy * methods adverse effects trends MeSH
- Radiotherapy methods standards utilization MeSH
- Outcome and Process Assessment, Health Care MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
x
x
- MeSH
- Analgesics administration & dosage adverse effects therapeutic use MeSH
- Survival Analysis MeSH
- Diphosphonates administration & dosage adverse effects therapeutic use MeSH
- Diagnostic Imaging methods trends utilization MeSH
- Antineoplastic Agents, Hormonal administration & dosage adverse effects therapeutic use MeSH
- Catheter Ablation methods trends utilization MeSH
- Congresses as Topic MeSH
- Humans MeSH
- Meta-Analysis as Topic MeSH
- Neoplasm Metastasis diagnosis radiotherapy MeSH
- Interdisciplinary Communication MeSH
- Bone Neoplasms * diagnosis secondary therapy MeSH
- Breast Neoplasms * diagnosis therapy MeSH
- Orthopedic Procedures methods trends MeSH
- Radiotherapy * methods trends utilization MeSH
- Practice Guidelines as Topic MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- MeSH
- Biological Therapy * methods trends MeSH
- Everolimus administration & dosage adverse effects therapeutic use MeSH
- Indoles administration & dosage adverse effects therapeutic use MeSH
- Carcinoma, Renal Cell diagnosis drug therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Metastasis * diagnosis drug therapy therapy MeSH
- Kidney Neoplasms * diagnosis drug therapy surgery MeSH
- Breast Neoplasms diagnosis therapy MeSH
- Niacinamide analogs & derivatives adverse effects therapeutic use MeSH
- Palliative Care methods utilization MeSH
- Pyrroles administration & dosage adverse effects therapeutic use MeSH
- Radiotherapy methods utilization MeSH
- Aged MeSH
- Intestinal Neoplasms diagnosis therapy MeSH
- Hand-Foot Syndrome diagnosis therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Biological Therapy methods utilization MeSH
- Drug Therapy methods utilization MeSH
- Clinical Trials, Phase III as Topic MeSH
- Humans MeSH
- Neoplasm Metastasis * diagnosis therapy MeSH
- Carcinoma, Non-Small-Cell Lung * diagnosis complications therapy MeSH
- Neurosurgical Procedures methods utilization MeSH
- Piperazines administration & dosage adverse effects therapeutic use MeSH
- Radiotherapy methods utilization MeSH
- Statistics as Topic MeSH
- Protein-Tyrosine Kinases * antagonists & inhibitors administration & dosage therapeutic use MeSH
- Check Tag
- Humans MeSH
The authors describe the possibilities of radiotherapy of prostate cancer and focus on certain controversies associated withproton therapy in this indication. They bring up to date published data on the results and risks associated with proton therapyin prostate irradiation. The work also contains presented case studies of patients with proton-related complications who havebeen or are being treated for urology.
Autoři popisují možnosti radioterapie karcinomu prostaty a soustřeďují se na určité kontroverze spojené s protonovou léčbou v této indikaci. Přinášejí dosud publikovaná data týkající se výsledků a rizik spojených s protonovou terapií při ozáření prostaty. Práce obsahuje také prezentované kazuistiky pacientů s komplikacemi po protonové terapii, kteří byli nebo jsou léčeni na urologii.
- MeSH
- European Union MeSH
- Carcinoma diagnosis radiotherapy therapy MeSH
- Humans MeSH
- Evidence-Based Medicine methods MeSH
- Meta-Analysis as Topic MeSH
- Prostatic Neoplasms * diagnosis radiotherapy therapy MeSH
- Neoplasms classification radiotherapy therapy MeSH
- Prostatectomy * methods trends utilization MeSH
- Proton Therapy * adverse effects trends utilization MeSH
- Radiotherapy, Intensity-Modulated adverse effects trends utilization MeSH
- Radiotherapy methods trends utilization MeSH
- Practice Guidelines as Topic standards MeSH
- Statistics as Topic MeSH
- Outcome and Process Assessment, Health Care MeSH
- Check Tag
- Humans MeSH
- Publication type
- Case Reports MeSH
- Review MeSH
- Geographicals
- Czech Republic MeSH
- United States MeSH
V článku je podán ucelený pohled na problematiku karcinomu mléčné žlázy se zaměřením na jeho léčbu s dělením do kapitol podle přítomnosti vzdálené diseminace, léčbě karcinomu prsu u těhotných žen, karcinomu prsu u mužů a zmíněn je přístup k jedincům s BRCA pozitivitou. Snahou bylo podat spíše zobecňující pohled na tuto obsáhlou problematiku.
In this article there is a complete look at breast cancer focused on its treatment. It is divided into chapters by the presence of distantmetastasis, the treatment of breast cancer in pregnant women and breast cancer in men. Approach to BRCA positive patients ismentioned too. The effort was to give generalised view on this comprehensive issue.
- MeSH
- Chemotherapy, Adjuvant methods trends utilization MeSH
- Surgical Procedures, Operative methods trends utilization MeSH
- Diagnostic Techniques and Procedures standards instrumentation utilization MeSH
- Drug Therapy methods trends utilization MeSH
- Genetic Predisposition to Disease MeSH
- Genes, BRCA1 MeSH
- Genes, BRCA2 MeSH
- Immunotherapy methods trends utilization MeSH
- Humans MeSH
- Mammography methods trends utilization MeSH
- Mastectomy classification methods trends MeSH
- Menstruation Disturbances complications MeSH
- Interdisciplinary Communication MeSH
- Breast Neoplasms epidemiology etiology therapy MeSH
- Neoadjuvant Therapy methods utilization MeSH
- Parturition physiology genetics immunology MeSH
- Radiotherapy methods trends utilization MeSH
- Risk Factors MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Primární kožní lymfomy patří mezi mimouzlinové nehodgkinské lymfomy, které jsou charakterizované přítomností maligních T nebo B lymfocytů v kůži. Většina primárních kožních lymfomů je zachycena v časných stadiích a má indolentní průběh s dobrou prognózou. Případy nemocí s agresivním chováním a nutností kombinované systémové a zevní léčby však nejsou výjimkou. Přehledový článek shrnuje diagnostiku a léčbu nejdůležitějších T- a B -buněčných kožních lymfomů s důrazem na dermatologickou manifestaci a na léčbu cílenou na kůži.
Primary cutaneous lymphomas are a rare type of extranodal non - Hodgkin lymphomas where malignant T-cells or B-cells infiltratethe skin. Most patients with primary cutaneous lymphomas are diagnosed in the early stage of the disease with usually indolentclinical course. However, cases with aggresive behaviour and unfavourable prognosis are not rare. This review summarizes diagnosisand treatment of the most important subtypes of cutaneous lymphomas with emphasis on dermatological manifestationsand skin directed therapy.
- MeSH
- Surgical Procedures, Operative methods utilization MeSH
- Dermatology methods trends MeSH
- Diagnostic Techniques and Procedures trends utilization MeSH
- Diagnosis, Differential MeSH
- Phototherapy methods utilization MeSH
- Disease Attributes MeSH
- Combined Modality Therapy * methods utilization MeSH
- Humans MeSH
- Interdisciplinary Communication * MeSH
- Mycosis Fungoides * diagnosis epidemiology therapy MeSH
- Skin Neoplasms diagnosis epidemiology classification MeSH
- Lymphoma, Non-Hodgkin * diagnosis drug therapy therapy MeSH
- Prognosis MeSH
- Radiotherapy methods utilization MeSH
- Practice Guidelines as Topic standards MeSH
- Neoplasm Staging methods trends utilization MeSH
- Statistics as Topic MeSH
- Tetrahydronaphthalenes administration & dosage adverse effects therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Geographicals
- Czech Republic MeSH
Mozkové metastázy představují důležitou a častou indikaci pro moderní radiochirurgii. Tato neinvazivní metoda nabízí dobrou lokální kontrolu s minimální toxicitou s možností opakování ozáření. CyberKnife je přístroj pro bezrámovou celotělovou radiochirurgii využívající obrazem řízenou robotickou technologii s lineárním akcelerátorem jako zdrojem fotonů. V naší prospektivní studii vyhodnocujeme velikost metastatických ložisek na MRI s využitím počítačově asistované volumetrie, přičemž srovnáváme prediktivní hodnotu objemových změn ozářených metastáz. Sledujeme efekt léčby v závislosti na histologickém typu nádoru, počtu mozkových metastáz, pohlaví a vstupním klinickém stavu pacientů. V našich podmínkách unikátní soubor pacientů léčených CyberKnife pro metastatické postižení mozku pak statisticky analyzujeme a výsledky srovnáváme s literárními daty pracovišť využívajících stejnou technologii i referenčními daty center rámové stereotaktické radiochirurgie (gama nůž).
Brain metastases are an important and frequently treated indication in modern radiosurgery. This non-invasive method offersgood local control with minimum toxicity and repeability of treatment. The CyberKnife is a device for frameless whole-bodyradiosurgery using image guided robotic technology and linear accelerator as a photon source. In our prospective study wemeasure the volume of brain metastases on MRI with use of computer-assisted volumetry and we evaluate the predictive valueof these volumetric changes. We track the effect of therapy according to histological type of tumor, number of brain metastases,sex and initial performance status of patients. The group of patients with CyberKnife treateted brain metastases, that is uniquein our conditions, is then statistically analyzed and results are compared to peer-reviewed articles of institutions using the sametechnology and reference data from frame-based (Gamma Knife) radiosurgery centers are matched.
- MeSH
- Survival Analysis * MeSH
- Diagnostic Techniques, Neurological instrumentation trends utilization MeSH
- Drug Therapy methods trends utilization MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods trends utilization MeSH
- Neoplasm Metastasis diagnosis radiotherapy therapy MeSH
- Brain Neoplasms * diagnosis surgery radiotherapy MeSH
- Neurosurgical Procedures methods trends utilization MeSH
- Radiosurgery methods trends utilization MeSH
- Radiotherapy methods trends utilization MeSH
- Statistics as Topic MeSH
- Stereotaxic Techniques * instrumentation trends utilization MeSH
- Outcome and Process Assessment, Health Care MeSH
- Check Tag
- Humans MeSH
Anti-HER2 léčba pertuzumabem a trastuzumabem u časného karcinomu prsu snižuje riziko relapsu onemocnění o 1 % proti samotnému trastuzumabu při mediánu sledování 45,4 měsíce.
Anti-HER2 treatment with pertuzumab and trastuzumab in early breast cancer reduces the risk of relapse by 1 % against trastuzumab alone at median follow‑up of 45.4 months.
- MeSH
- Chemotherapy, Adjuvant methods utilization MeSH
- Contraception methods utilization MeSH
- Biological Therapy methods trends utilization MeSH
- Surgical Procedures, Operative * methods utilization MeSH
- Heredity genetics MeSH
- Diagnostic Techniques and Procedures * MeSH
- Hormone Replacement Therapy methods adverse effects MeSH
- Disease Attributes MeSH
- Humans MeSH
- Mammography methods trends utilization MeSH
- Menstruation MeSH
- Meta-Analysis as Topic MeSH
- Breast Neoplasms * diagnosis etiology classification MeSH
- Obesity MeSH
- Mass Screening methods trends utilization MeSH
- Radiotherapy methods utilization MeSH
- Risk Factors MeSH
- Statistics as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
