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MeSH: Visual Pathways-diagnostic imaging

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CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: Subtle Retinal Changes in Optical Coherence Tomography

Ingwersen, Jens
Author Ingwersen, Jens ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Graf, Jonas
Author Graf, Jonas ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Kluge, Julia
Author Kluge, Julia From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Weise, Margit
Author Weise, Margit From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Dietrich, Michael
Author Dietrich, Michael From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Lee, John-Ih
Author Lee, John-Ih ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Harmel, Jens
Author Harmel, Jens ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Hartung, Hans-Peter
Author Hartung, Hans-Peter From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Ruck, Tobias
Author Ruck, Tobias ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic
Meuth, Sven G
Author Meuth, Sven G ORCID From the Department of Neurology (J.A., J.G., J.K., M.W., M.D., J.-I.L., J.H., H.-P.H., T.R., S.G.M., P.A., O.A., M.R.), Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany Brain and Mind Centre (H.-P.H.), University of Sydney Department of Neurology (H.-P.H.), Medical University of Vienna, Austria Department of Neurology (H.-P.H., M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Germany and Department of Neurology (H.-P.H.), Palacky University in Olomouc, Olomouc, Czech Republic

Neurology® neuroimmunology & neuroinflammation. 2022 ; 9 (1) : . [pub] 20211019

Neurol Neuroimmunol Neuroinflamm
ISSN 2332-7812
Medvik
Source

BACKGROUND AND OBJECTIVES: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease primarily affecting the peripheral nervous system. However, several noncontrolled studies have suggested concomitant inflammatory CNS demyelination similar to multiple sclerosis. The aim of this study was to investigate an involvement of the visual pathway in patients with CIDP. METHODS: In this prospective cross-sectional study, we used high-resolution spectral-domain optical coherence tomography to compare the thickness of the peripapillary retinal nerve fiber layer and the deeper macular retinal layers as well as the total macular volume (TMV) in 22 patients with CIDP and 22 age-matched and sex-matched healthy control (HC) individuals. Retinal layers were semiautomatically segmented by the provided software and were correlated with clinical measures and nerve conduction studies. RESULTS: In patients with CIDP compared with healthy age-matched and sex-matched controls, we found slight but significant volume reductions of the ganglion cell/inner plexiform layer complex (CIDP 1.86 vs HC 1.95 mm3, p = 0.015), the retinal pigment epithelium (CIDP 0.38 vs HC 0.40 mm3, p = 0.02), and the TMV (CIDP 8.48 vs HC 8.75 mm3, p = 0.018). The ganglion cell layer volume and motor nerve conduction velocity were positively associated (B = 0.002, p = 0.02). DISCUSSION: Our data reveal subtle retinal neurodegeneration in patients with CIDP, providing evidence for visual pathway involvement, detectable by OCT. The results need corroboration in independent, larger cohorts.

MeSH
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating diagnostic imaging pathology physiopathology MeSH
Adult MeSH
Middle Aged MeSH
Humans MeSH
Neural Conduction physiology MeSH
Tomography, Optical Coherence MeSH
Prospective Studies MeSH
Cross-Sectional Studies MeSH
Retina diagnostic imaging pathology MeSH
Aged MeSH
Visual Pathways diagnostic imaging pathology MeSH
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Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH

Article

Magnetická rezonance v oftalmologii
[Magnetic resonance in ophthalmology]

Postgraduální medicína. 2018 ; 20 (1) : 98-102.

Postgraduální med.
ISSN 1212-4184
Medvik
Source

MeSH
Contraindications MeSH
Humans MeSH
Magnetic Resonance Imaging * methods instrumentation MeSH
Eye Diseases diagnostic imaging MeSH
Orbit diagnostic imaging MeSH
Visual Pathways diagnostic imaging MeSH
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Humans MeSH

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