This review reports on inhibitors of copper-containing amine oxidases and flavoprotein polyamine oxidases, which are structurally based on diamines. In the introduction, basic characteristics and classification of amine oxidases are described together with the significance of their synthetic inhibitors. The following text is divided into several chapters, which deal with diaminoketones, aza-diamines, unsaturated diamine analogs and diamines with heterocyclic substituents. Then it continues with diamine- and agmatine-based inhibitors of polyamine oxidases. Each chapter gives detailed information on the inhibition mode, potency and structural relationships. The conclusion points out possible roles of mechanism-based inhibitors of amine oxidases in physiological and medicinal research.
- MeSH
- agmatin farmakologie chemie MeSH
- aktivace enzymů fyziologie účinky léků MeSH
- diaminy farmakologie chemie MeSH
- financování organizované MeSH
- histaminasa antagonisté a inhibitory metabolismus MeSH
- inhibitory enzymů farmakologie chemie MeSH
- ketony farmakologie chemie MeSH
- lidé MeSH
- molekulární struktura MeSH
- oxidoreduktasy působící na CH-NH vazby antagonisté a inhibitory metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- histaminasa antagonisté a inhibitory MeSH
- hydraziny farmakologie MeSH
- kinetika MeSH
- zelenina enzymologie MeSH
- Publikační typ
- srovnávací studie MeSH
