Cancer is viewed as a genetic disease. According to the currently accepted model of carcinogenesis, several consequential mutations in oncogenes or tumor suppressor genes are necessary for cancer development. In this model, mutated DNA sequence is transcribed to mRNA that is finally translated into functionally aberrant protein. mRNA is viewed solely as an intermediate between DNA (with 'coding' potential) and protein (with 'executive' function). However, recent findings suggest that (m)RNA is actively regulated by a variety of processes including nonsense-mediated decay, alternative splicing, RNA editing or RNA interference. Moreover, RNA molecules can regulate a variety of cellular functions through interactions with RNA, DNA as well as protein molecules. Although, the precise contribution of RNA molecules by themselves and RNA-regulated processes on cancer development is currently unknown, recent data suggest their important role in carcinogenesis. Here, we summarize recent knowledge on RNA-related processes and discuss their potential role in cancer development.
- MeSH
- alternativní sestřih MeSH
- editace RNA MeSH
- financování organizované MeSH
- lidé MeSH
- messenger RNA genetika metabolismus MeSH
- modely genetické MeSH
- nádory genetika patologie MeSH
- regulace genové exprese MeSH
- RNA interference MeSH
- stabilita RNA MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
