Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on numerous clinical trials are available for chronic phase disease. However for CML in the blast phase (CML-BP), prognosis remains poor and treatment options are much more limited. The spectrum of treatment strategies for children and adolescents with CML-BP has largely evolved empirically and includes treatment principles derived from adult CML-BP and pediatric acute leukemia. Given this heterogeneity of treatment approaches, we formed an international panel of pediatric CML experts to develop recommendations for consistent therapy in children and adolescents with this high-risk disease based on the current literature and national standards. Recommendations include detailed information on initial diagnosis and treatment monitoring, differentiation from Philadelphia-positive acute leukemia, subtype-specific selection of induction therapy, and combination with tyrosine kinase inhibitors. Given that allogeneic hematopoietic stem cell transplantation currently remains the primary curative intervention for CML-BP, we also provide recommendations for the timing of transplantation, donor and graft selection, selection of a conditioning regimen and prophylaxis for graft-versus-host disease, post-transplant TKI therapy, and management of molecular relapse. Management according to the treatment recommendations presented here is intended to provide the basis for the design of future prospective clinical trials to improve outcomes for this challenging disease.
- MeSH
- akutní myeloidní leukemie * MeSH
- blastická krize terapie MeSH
- chronická myeloidní leukemie * farmakoterapie diagnóza MeSH
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- nemoc štěpu proti hostiteli * MeSH
- prognóza MeSH
- transplantace hematopoetických kmenových buněk * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- akcelerovaná fáze myeloidní leukemie terapie MeSH
- blastická krize terapie MeSH
- chronická fáze myeloidní leukemie terapie MeSH
- homologní transplantace trendy využití MeSH
- lidé MeSH
- medicína založená na důkazech trendy MeSH
- piperaziny aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- přežití bez známek nemoci MeSH
- pyrimidiny aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- transplantace hematopoetických kmenových buněk trendy využití MeSH
- tyrosinkinasy antagonisté a inhibitory terapeutické užití MeSH
- Check Tag
- lidé MeSH
