Učebnice dává prostor léčivům z výbavy většiny lékařů v praxi i léčivům v gesci užšího okruhu odborníků. Nakladatelská anotace. Kráceno; Nové vydání skvělé učebnice farmakologie, kterou využívají pro její stručnost a přehlednost nejen studenti zdravotnických oborů, ale i medici a lékaři v praxi.

• MeSH
• farmakologie MeSH

• Konspekt
• Farmacie. Farmakologie
• Učební osnovy. Vyučovací předměty. Učebnice
• NLK Obory
• farmacie a farmakologie
• NLK Publikační typ
• učebnice vysokých škol

BACKGROUND: The interaction between chronic medications on admission and the association between serum potassium level and outcome in patients with acute heart failure (AHF) are unknown. METHODS: Observational intercontinental study of patients admitted with AHF. 15954 patients were included from 12 cohorts in 4 continents. Main outcome was 90-day mortality. Clinical presentation (medication use, hemodynamics, comorbidities), demographic, echocardiographic, and biochemical data on admission were recorded prospectively in each cohort, with prospective adjudication of outcomes. RESULTS: Positive and negative linear relationships between 90-day mortality and sK+ above 4.5 mmol/L (hyperkalemia) and below 3.5 mmol/L (hypo-kalemia) were observed. Hazard ratio for death was 1.46 [1.34-1.58] for hyperkalemia and 1.22 [1.06-1.40] for hypokalemia. In a fully adjusted model, only hyperkalemia remained associated with mortality (HR 1.03 [1.02-1.04] for each 0.1 mmol/l change of sK+ above 4.5 mmol/L). Interaction tests revealed that the association between hyperkalemia and outcome was significantly affected by chronic medications. The association between hyperkalemia and mortality was absent for patients treated with beta blockers and in those with preserved renal function. CONCLUSIONS: In patients with AHF, sK+ > 4.5 mmol/L appears to be associated with 90-day mortality. B-blockers have potentially a protective effect in the setting of hyperkalemia.

• MeSH
• akutní nemoc MeSH
• beta blokátory terapeutické užití   MeSH
• biologické markery krev   MeSH
• časové faktory MeSH
• draslík krev   MeSH
• hyperkalemie etiologie   mortalita   prevence a kontrola   MeSH
• hypokalemie etiologie   mortalita   prevence a kontrola   MeSH
• lidé středního věku MeSH
• lidé MeSH
• míra přežití trendy   MeSH
• následné studie MeSH
• prospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• srdeční selhání krev   komplikace   farmakoterapie   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH
• Spojené státy americké epidemiologie   MeSH

Two structurally different copper(II) complexes of the compositions [{Cu(9dhx)(H2O)3}2(µ-SO4)2] (1) and [Cu(9dhx)2(H2O)2(NO3)2]·H2O (2), involving 9-deazahypoxanthine (9dhx; 6-oxo-9-deazapurine; 9-deazahypoxanthine), have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, electrospray ionisation (ESI) mass spectrometry, thermogravimetric (TG) and differential thermal (DTA) analyses, and cyclic voltammetry. The X-ray structures of complexes 1 and [Cu(9dhx)2(H2O)2(NO3)2] (2a) revealed the distorted octahedral geometry in the vicinity of the copper(II) atoms, with the NO5 and N2O4 donor set, respectively. In the dimeric compound 1, the {Cu(9dhx)(H2O)3}2 units are bridged by sulfate groups with the Cu···Cu separation being 5.3446(2) Å. In both structures the 9dhx ligands are coordinated through the N3 atoms of the pyrimidine moieties. The SOD-like activity of complexes 1 and 2 was evaluated in vitro showing moderate effect, with the IC50 values equal to 18.20, and 53.33 μM, respectively.

• MeSH
• biokompatibilní materiály chemie   metabolismus   MeSH
• elektrochemické techniky MeSH
• hmotnostní spektrometrie s elektrosprejovou ionizací MeSH
• hypoxanthiny chemie   MeSH
• komplexní sloučeniny chemie   metabolismus   MeSH
• krystalografie rentgenová MeSH
• měď chemie   MeSH
• molekulární konformace MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• superoxiddismutasa metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Analysis of over 500 groundwater samples from throughout the Red River Delta indicates de-coupling of dissolved arsenic (As) and dissolved iron (Fe). Sorting of all data along the redox potentials suggests re-adsorption of As released initially from Mn(IV)-oxyhydroxides and later from Fe(III)-oxyhydroxides on remaining ferric phases at moderate redox levels. A gradually decreasing specific surface area available for re-adsorption of As probably plays a role as a consequence of limited reactivity of more crystalline phases such as goethite and hematite. At low redox levels, concentrations of Fe and phosphate decrease, but As concentrations keep increasing and most As is present as As(III) with limited adsorption affinity. Based on the results of speciation modeling, the water is supersaturated with respect to siderite and vivianite. A general conceptual model of As and Fe behavior is presented, suggesting that coupled behavior is possible in two geochemical "windows", i.e., 1: between saturation of remaining adsorption sites and the onset of siderite and vivianite precipitation, and 2: after the beginning of secondary sulfide phases precipitation and during methanogenesis. The de-coupling of As from Fe is common and has been observed at many sites around the world where As is released as a consequence of redox processes, e.g., in Bangladesh, West Bengal and Assam in India, the Mekong Delta in Cambodia and Vietnam, and Taiwan. The presented general conceptual model of de-coupling processes can be applied to the interpretation of As and Fe data, and, thus, it can help in the preparation of a site conceptual model which is a necessary prerequisite for reactive transport modeling.

• MeSH
• arsen analýza   MeSH
• chemické látky znečišťující vodu MeSH
• epidemiologické monitorování MeSH
• geologické sedimenty analýza   chemie   MeSH
• monitorování životního prostředí metody   MeSH
• oxidace-redukce MeSH
• řeky MeSH
• teoretické modely MeSH
• uhličitany MeSH
• železité sloučeniny analýza   MeSH
• železo analýza   MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Bangladéš MeSH
• Indie MeSH
• Kambodža MeSH
• Taiwan MeSH
• Vietnam MeSH