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Autor
Ashokkumar, Muthupandian 1 Beretta, Giovanni Luca 1 Bhangu, Sukhvir Kaur 1 Caruso, Frank 1 Cassani, Marco 1 Cavalieri, Francesca 1 Fernandes, Soraia 1 Forte, Giancarlo 1 Hodan, Radomír 1 Komínek, Pavel 1 Matoušek, Petr 1 Novák, Vilém 1 Pilatis, Irinaios 1 Pniak, Tomáš 1 Radziwon, Agata 1 Sarpaki, Sophia 1 Tinelli, Stella 1 Wojnilowicz, Marcin 1 Zaffaroni, Nadia 1
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Pracoviště
BIOEMTECH 27 Neapoleos st Lefkippos A... 1 Department of Chemical Engineering Th... 1 Dipartimento di Scienze e Tecnologie ... 1 International Clinical Research Cente... 1 Molecular Pharmacology Unit Departmen... 1 ORL klinika FN Ostrava 1 School of Chemistry The University of... 1 School of Science RMIT University Mel... 1
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Autor
Ashokkumar, Muthupandian 1 Beretta, Giovanni Luca 1 Bhangu, Sukhvir Kaur 1 Caruso, Frank 1 Cassani, Marco 1 Cavalieri, Francesca 1 Fernandes, Soraia 1 Forte, Giancarlo 1 Hodan, Radomír 1 Komínek, Pavel 1 Matoušek, Petr 1 Novák, Vilém 1 Pilatis, Irinaios 1 Pniak, Tomáš 1 Radziwon, Agata 1 Sarpaki, Sophia 1 Tinelli, Stella 1 Wojnilowicz, Marcin 1 Zaffaroni, Nadia 1
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Pracoviště
BIOEMTECH 27 Neapoleos st Lefkippos A... 1 Department of Chemical Engineering Th... 1 Dipartimento di Scienze e Tecnologie ... 1 International Clinical Research Cente... 1 Molecular Pharmacology Unit Departmen... 1 ORL klinika FN Ostrava 1 School of Chemistry The University of... 1 School of Science RMIT University Mel... 1
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"690901" Dotaz Zobrazit nápovědu
PubMed
35100658
DOI
10.1002/adma.202107964
Knihovny.cz E-zdroje
Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor-selective drugs. Here, as a proof-of-concept, the use of high-frequency sound waves is demonstrated to transform the nonselective anthracycline doxorubicin into a tumor selective drug molecule. The transformed drug self-aggregates in water to form ≈200 nm nanodrugs without requiring organic solvents, chemical agents, or surfactants. The nanodrugs preferentially interact with lipid rafts in the mitochondria of cancer cells. The mitochondrial localization of the nanodrugs plays a key role in inducing reactive oxygen species mediated selective death of breast cancer, colorectal carcinoma, ovarian carcinoma, and drug-resistant cell lines. Only marginal cytotoxicity (80-100% cell viability) toward fibroblasts and cardiomyocytes is observed, even after administration of high doses of the nanodrug (25-40 μg mL-1 ). Penetration, cytotoxicity, and selectivity of the nanodrugs in tumor-mimicking tissues are validated by using a 3D coculture of cancer and healthy cells and 3D cell-collagen constructs in a perfusion bioreactor. The nanodrugs exhibit tropism for lung and limited accumulation in the liver and spleen, as suggested by in vivo biodistribution studies. The results highlight the potential of this approach to transform the structure and bioactivity of anticancer drugs and antibiotics bearing sono-active moieties.
- MeSH
- antibiotika antitumorózní chemie MeSH
- doxorubicin chemie farmakologie MeSH
- lidé MeSH
- nádory vaječníků * MeSH
- nanočástice * chemie MeSH
- tkáňová distribuce MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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