Kent, David E*
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BACKGROUND: Structural changes in collagen and elastin fiber density have been previously evaluated by qualitative histological studies; however, quantitative evaluations are lacking. AIM: To evaluate quantitative changes in collagen and elastin fibers in the vaginal wall in a porcine model after volumetric radiofrequency heating with an intravaginal applicator. METHODS: An animal model was used (domestic pig, multipara: 5.67 ± 0.94 deliveries, 3 years of age). Three pigs under general anesthesia were treated (8-minute, vaginal canal area) once per week for the course of three weeks. There were 2 follow-up evaluations at one and four weeks. Histology specimens were obtained via punch biopsy under ultrasound control. Ultrasound video measurements of the vaginal wall thickness were also obtained. Tissue samples were stained by H&E as well as stains for collagen and elastin fibers. RESULTS: Elastin (P < .001) and collagen (P < .01) fiber density increased after every treatment. The measured increase in fibers was highest at the one-week follow-up. Elastin accounted on average for 51.46 ± 16.86% of the tissue examined (increase of 36.8% points), while collagen accounted on average for 44.83 ± 18.92% (increase of 17.1% points). The number of synthetically active cells was increased by 16%. While vaginal wall thickness did show an increase of 1.66 mm (32%), this tendency was not statistically significant (P > .05). CONCLUSION: Results suggest that volumetric heating of vaginal tissue produced quantitative improvement in the connective tissue organization in a porcine study. Neocollagenesis and neoelastogenesis were observed with an increased number of synthetically active cells.
- MeSH
- elastin analýza biosyntéza MeSH
- kolagen analýza biosyntéza MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- pojivová tkáň patologie účinky záření MeSH
- radiofrekvenční terapie přístrojové vybavení metody MeSH
- Sus scrofa MeSH
- vagina patologie účinky záření MeSH
- vaginální onemocnění patologie terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky veterinární MeSH
210 s. : obr., tab., přeruš.bibliogr.
BACKGROUND: The quality of one's facial appearance diminishes with aging as skin and underlying soft tissues deteriorate. Connective tissue and musculofascial degeneration leads to skin laxity and wrinkles developing. OBJECTIVE: To evaluate the effects of synchronized radiofrequency with high intensity facial stimulation technology on dermal collagen and elastin fibers in a porcine model. MATERIALS AND METHODS: Eight sows were divided into Active (N = 6) and Control (N = 2) groups. Synchronized radiofrequency and high intensity facial stimulation were delivered to the ventrolateral abdomen. The Active group received four 20-minute treatments, once a week. Control group was untreated. Skin biopsy sample were histologically analyzed for connective tissue changes pre- and post-treatment. Data were analyzed statistically (α = 0.05). RESULTS: In the Active group: the collagen-occupied area at baseline was 1.12 ± 0.09 × 106 μm 2 and increased by +19.6% ( p < .001) at 1-month and by +26.3% ( p < .001) 2 months post-treatment; elastin-occupied area at baseline was 0.11 ± 0.03 × 106 μm 2 and increased by +75.9% ( p < .001) at 1-month and +110.8% ( p < .001) at 2-months follow-up. No significant changes ( p > .05) found in the Control samples. CONCLUSION: Collagen and elastin fiber content increased significantly after treatments. Connective tissue in the treatment area was denser up to 2-months post-treatment.
- MeSH
- elastin MeSH
- kolagen MeSH
- kůže MeSH
- modely u zvířat MeSH
- obličejové svaly * MeSH
- prasata MeSH
- stárnutí kůže * MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- koronární jednotka FN Motol,
- MeSH
- akutní koronární syndrom * dějiny MeSH
- kardiologie MeSH
- kardiovaskulární nemoci etiologie MeSH
- lidé MeSH
- nemocniční oddělení * MeSH
- ošetřovatelství - vzorové postupy * MeSH
- péče o pacienta MeSH
- příznaky a symptomy MeSH
- trombolytická terapie MeSH
- Check Tag
- lidé MeSH
3rd ed. XVIII, 608 s. : il., tab., grafy ; 24 cm
4th ed. XXVIII, 1092 s. : fot., obr., tab., grafy ; 29 cm
- MeSH
- rodinné lékařství MeSH
- Publikační typ
- příručky MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- lékařství
- všeobecné lékařství
xiii, 279 s. : il., tab., grafy ; 21 cm
- MeSH
- diagnóza MeSH
- management nemoci MeSH
- metody pro podporu rozhodování MeSH
- příznaky a symptomy MeSH
- rodinné lékařství MeSH
- Publikační typ
- příručky MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- všeobecné lékařství
Převodní systém srdeční byl ve formě přítomné u teplokrevných obratlovců úplně popsán před 110 lety. Navzdory tomu bylo v poslední době získáno množství poznatků o jeho specifikaci a vývoji, jež mají význam pro jeho funkci při tvorbě a vedení vzruchu srdcem. Poruchy převodního systému jsou spojovány s arytmiemi, z nichž některé mají vývojový podklad. Evoluční pohled na tuto problematiku je užitečný zejména pro lepší pochopení přestavby síňokomorového kanálu.
Cardiac conduction system was described in its complete form in homeotherm vertebrates 110 years ago. Despite this fact, many new findings concerning its specification and development that have an impact on its pacemaking and conducting function appeared in the past decade. Conduction system disorders are associated with arrhythmias, and some of which have a developmental origin. Evolutionary view on this area is particularly useful for better understanding of the atrioventricular canal remodelling.
... Ehlert -- 8. Muscarinic Antagonists and Their Clinical Uses, 74 -- F.J. Ehlert -- 9. ... ... Edwards -- 28. Opioid Analgesics, 237 Susan L. Ingram and Elena E. Bagley -- 29. ... ... Elmslie -- 33. Drug Treatment for Allergic Reactions, 273 -- Kirk E. ... ... Vasodilators for Hypertensive Crises, Pulmonary Hypertension, and Erectile Dysfunction, 330 -- David ... ... Karpa, and Kent Ł Vrana -- 47. ...
Sixth edition. xiv, 714 stran : barevné ilustrace ; 28 cm
- MeSH
- farmakologie * MeSH
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- farmakoterapie
- farmacie a farmakologie
- NLK Publikační typ
- kolektivní monografie
