Low-flow peripheral vascular reconstruction
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Introduction: The aim of this study was to develop a prototype of an artificial blood vessel which has similar mechanical properties to a human saphenous vein graft and to experimentally verify the function of the prosthesis via ovine carotid bypass implantation. Material and methods: The prototype of an artificial graft prosthesis for low flow was developed and manufactured from a collagenous matrix and reinforcing polyester mesh. We compared the results of both the pressurisation and the mechanical stress evaluation tests of VSM with four types of hybrid vascular graft. The most similar graft (type II) was chosen for the first ovine model implantation. Results: Dominant behavior e.g. mechanical response of VSM graft in plots of circumferential and axial stress during loading is observed in circumferential direction. Average results of used VSM showed area of ideal mechanical response and the properties of artificial blood vessels were fitted into this area. Developed graft remained patent after 161 days of follow up in ovine model. Conclusions: The mechanical properties of the graft were designed and adjusted to be similar to the behaviour of human saphenous veins. This approach showed promising results and enhanced the final performance of the prosthesis.
Aim: The aim of this study was to evaluate short-term patency of the new prosthetic graft and its structural changes after explantation. Methods: The study team developed a three-layer conduit composed of a scaffold made from polyester coated with collagen from the inner and outer side with an internal diameter of 6 mm. The conduit was implanted as a bilateral bypass to the carotid artery in 7 sheep and stenosis was created in selected animals. After a period of 161 days, the explants were evaluated as gross and microscopic specimens. Results: The initial flow rate (median ± IQR) in grafts with and without artificial stenosis was 120 ± 79 ml/min and 255 ± 255 ml/min, respectively. Graft occlusion occurred after 99 days in one of 13 conduits (patency rate: 92%). Wall-adherent thrombi occurred only in sharp curvatures in two grafts. Microscopic evaluation showed good engraftment and preserved structure in seven conduits; inflammatory changes with foci of bleeding, necrosis, and disintegration in four conduits; and narrowing of the graft due to thickening of the wall with multifocal separation of the outer layer in two conduits. Conclusions: This study demonstrates good short-term patency rates of a newly designed three-layer vascular graft even in low-flow conditions in a sheep model.
- MeSH
- arteriae carotides účinky léků MeSH
- cévní protézy MeSH
- cévy - implantace protéz metody MeSH
- kolagen metabolismus MeSH
- okluze cévního štěpu farmakoterapie MeSH
- ovce MeSH
- prospektivní studie MeSH
- protézy - design metody MeSH
- průchodnost cév účinky léků MeSH
- zákroky plastické chirurgie metody MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
... Siegelbaum -- The Action Potential Is Generated by the Flow of Ions Through Voltage-Gated Channels 150 ... ... Channels at the End-Plate 190 -- The Synaptic Potential at the End-Plate Is Produced by Ionic Current Flowing ... ... 190 -- The Ion Channel at the End-Plate Is Permeable to Both Sodium and Potassium 191 -- The Current Flow ... ... Kandel -- Tactile Information About an Object Is Fragmented by Peripheral Sensors and Must Be Integrated ... ... Kandel -- The Peripheral Components of Emotion Prepare the Body for Action and Communicate Our Emotional ...
4th ed. xxxiii, 1414 s. : il., tab., grafy ; 30 cm
- MeSH
- chování MeSH
- molekulární biologie MeSH
- nemoci nervového systému MeSH
- nervový systém MeSH
- neurochemie MeSH
- neurofyziologie MeSH
- neurony MeSH
- neurovědy MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Fyziologie člověka a srovnávací fyziologie
- NLK Obory
- neurovědy
- biologie
