The advanced glycated end products (AGEs) are formed in the diabetic patients; it is a major cause of macrovascular and microvascular complications in diabetes. Clinically there is no treatment available for the AGEs. Stveoside (Stv), a sweetener has potent anti-diabetic and anti-oxidant activity. Hence, we investigated its use in prevention of AGEs formation using in vitro and in vivo models. Diabetes was induced by streptozotocin (STZ). These rats were kept without treatment till blood HbA1c was markedly increased. They were then divided into 5 groups and treated orally with vehicle or Metformin (MET) or Stv respectively for 28 days. Every 7th day, animals were tested for body weight and blood glucose (BG). On the last day of treatment, all the groups were evaluated for physiological and biochemical parameters, histopathology and AGEs; N-carboxymethyl-lysine (CML) estimation. Stv showed inhibition of AGEs in in vitro as well as in in vivo respectively. Positive effects were seen on the BG, lipid profile and urine parameters as well it showed reduced formation of CML. It also showed antihyperglycaemic, antihyperlipedemic and nephroprotective activities. The present study provides scientific rationale for the use of Stv as a sweetener with additional benefits in diabetes.

• MeSH
• diabetes mellitus * prevence a kontrola   terapie   MeSH
• fytoterapie MeSH
• glykosidy terapeutické užití   MeSH
• glykosylace * účinky léků   MeSH
• komplikace diabetu * terapie   MeSH
• krevní glukóza účinky léků   MeSH
• krysa rodu rattus MeSH
• lidé MeSH
• lipidy MeSH
• modely nemocí na zvířatech MeSH
• produkty pokročilé glykace * MeSH
• renální insuficience prevence a kontrola   MeSH
• sladidla terapeutické užití   MeSH
• Stevia * MeSH
• techniky in vitro MeSH
• Check Tag
• krysa rodu rattus MeSH
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH