• MeSH
• Internal Medicine MeSH
• Publication type
• Textbook MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• vnitřní lékařství
• NML Publication type
• kolektivní monografie

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. We now update these "MISEV2014" guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

• Publication type
• Journal Article MeSH

Management boundaries that define populations or stocks of fish form the basis of fisheries planning. In the Arctic, decreasing sea ice extent is driving increasing fisheries development, highlighting the need for ecological data to inform management. In Cumberland Sound, southwest Baffin Island, an indigenous community fishery was established in 1987 targeting Greenland halibut (Reinhardtius hippoglossoides) through the ice. Following its development, the Cumberland Sound Management Boundary (CSMB) was designated and a total allowable catch (TAC) assigned to the fishery. The CSMB was based on a sink population of Greenland halibut resident in the northern section of the Sound. Recent fishing activities south of the CSMB, however, raised concerns over fish residency, the effectiveness of the CSMB and the sustainability of the community-based winter fishery. Through acoustic telemetry monitoring at depths between 400 and 1200 m, and environmental and fisheries data, this study examined the movement patterns of Greenland halibut relative to the CSMB, the biotic and abiotic factors driving fish movement and the dynamics of the winter fishery. Greenland halibut undertook clear seasonal movements between the southern and northern regions of the Sound driven by temperature, dissolved oxygen, and sea ice cover with most fish crossing the CSMB on an annual basis. Over the lifespan of the fishery, landfast ice cover initially declined and then became variable, limiting accessibility to favored fisher locations. Concomitantly, catch per unit effort declined, reflecting the effect of changing ice conditions on the location and effort of the fishery. Ultimately, these telemetry data revealed that fishers now target less productive sites outside of their favored areas and, with continued decreases in ice, the winter fishery might cease to exist. In addition, these novel telemetry data revealed that the CSMB is ineffective and led to its relocation to the entrance of the Sound in 2014. The community fishery can now develop an open-water fishery in addition to the winter fishery to exploit the TAC, which will ensure the longevity of the fishery under projected climate-change scenarios. Telemetry shows great promise as a tool for understanding deep-water species and for directly informing fisheries management of these ecosystems that are inherently complex to study.

• MeSH
• Animal Migration MeSH
• Oceans and Seas MeSH
• Flounder * MeSH
• Animal Distribution * MeSH
• Fisheries * MeSH
• Remote Sensing Technology MeSH
• Conservation of Natural Resources methods   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Arctic Regions MeSH
• Canada MeSH
• Oceans and Seas MeSH

• MeSH
• Information Literacy MeSH
• Information Dissemination MeSH
• Health Communication MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Výchova a vzdělávání
• NML Fields
• knihovnictví, informační věda a muzeologie

• MeSH
• Surgical Procedures, Operative MeSH
• Tissue and Organ Harvesting MeSH
• Organ Transplantation * MeSH
• Publication type
• Textbook MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• transplantologie
• NML Publication type
• kolektivní monografie

• MeSH
• Hematopoietic System MeSH
• Lymphoid Tissue MeSH
• Lymphoma MeSH
• Neoplasms MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• cytologie, klinická cytologie
• hematologie a transfuzní lékařství
• NML Publication type
• publikace WHO

• Keywords
• hematologie,
• MeSH
• Classification MeSH
• Blood Cells MeSH
• Hematologic Diseases classification   MeSH
• Lymphoid Tissue MeSH
• Tumor Burden MeSH

• NML Fields
• hematologie a transfuzní lékařství
• Světová zdravotnická organizace

• MeSH
• Cardiology MeSH
• Young Adult MeSH
• Pediatrics MeSH
• Heart Failure diagnosis   therapy   MeSH
• Check Tag
• Young Adult MeSH

• Conspectus
• Pediatrie
• Učební osnovy. Vyučovací předměty. Učebnice
• NML Fields
• kardiologie
• pediatrie
• NML Publication type
• kolektivní monografie
• učebnice vysokých škol

• MeSH
• Analgesia MeSH
• Pain diagnosis   drug therapy   MeSH
• Treatment Outcome MeSH
• Publication type
• Congress MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• anesteziologie a intenzivní lékařství

• MeSH
• Child MeSH
• Immunization MeSH
• Immunosuppressive Agents MeSH
• Organ Transplantation MeSH
• Transplantation Immunology MeSH
• Check Tag
• Child MeSH

• Conspectus
• Pediatrie
• NML Fields
• pediatrie
• transplantologie