The L-forms of the Klecha 155 strain were induced in vitro by methicillin. After reversion, the strains were tested for 19 biochemical features and for susceptibility to penicillin, ampicillin and methicillin. Two reverted strains were less virulent for mice than the parent strain. It is concluded that the decrease in virulence of reverted Staph. aureus strains is correlated with changes in the chemical structure and composition of the cell wall after reversion from the L-phase variants.
- MeSH
- Ampicillin pharmacology MeSH
- Glucose metabolism MeSH
- Mice, Inbred Strains MeSH
- L Forms pathogenicity MeSH
- Lethal Dose 50 MeSH
- Methicillin pharmacology MeSH
- Mice MeSH
- Penicillins pharmacology MeSH
- Polysorbates metabolism MeSH
- Staphylococcal Infections microbiology MeSH
- Staphylococcus aureus drug effects metabolism pathogenicity MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Ampicillin MeSH
- Glucose MeSH
- Methicillin MeSH
- Penicillins MeSH
- Polysorbates MeSH
The pathogenicity of B. abortus 870 L-forms obtained by long-term passaging of virulent culture on media with penicillin and of revertants obtained in vitro and in vivo was studied. L-form cultures stimulated only a mild response of the reticulo-endothelial system of the animal organism, at the same time displaying a certain level of toxicity. In vitro revertants approximated to L-forms, while in vivo revertants stood closer to the initial virulent culture, as regards pathogenicity. This seems to be evidence of a potential danger of brucella L-forms for the human and animal organisms.
- MeSH
- Brucella abortus growth & development immunology pathogenicity MeSH
- Brucellosis immunology microbiology MeSH
- Species Specificity MeSH
- Hemagglutinins analysis MeSH
- Culture Media MeSH
- L Forms immunology pathogenicity MeSH
- Guinea Pigs MeSH
- Penicillins pharmacology MeSH
- Virulence MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hemagglutinins MeSH
- Culture Media MeSH
- Penicillins MeSH
