framework development
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Microbial electrosynthesis (MES) presents a versatile approach for efficiently converting carbon dioxide (CO2) into valuable products. However, poor electron uptake by the microorganisms from the cathode severely limits the performance of MES. In this study, a graphitic carbon nitride (g-C3N4)-metal-organic framework (MOF) i.e. HKUST-1 composite was newly designed and synthesized as the cathode catalyst for MES operations. The physiochemical analysis such as X-ray diffraction, scanning electron microscopy (SEM), and X-ray fluorescence spectroscopy showed the successful synthesis of g-C3N4-HKUST-1, whereas electrochemical assessments revealed its enhanced kinetics for redox reactions. The g-C3N4-HKUST-1 composite displayed excellent biocompatibility to develop electroactive biohybrid catalyst for CO2 reduction. The MES with g-C3N4-HKUST-1 biohybrid demonstrated an excellent current uptake of 1.7 mA/cm2, which was noted higher as compared to the MES using g-C3N4 biohybrid (1.1 mA/cm2). Both the MESs could convert CO2 into acetic and isobutyric acid with a significantly higher yield of 0.46 g/L.d and 0.14 g/L.d respectively in MES with g-C3N4-HKUST-1 biohybrid and 0.27 g/L.d and 0.06 g/L.d, respectively in MES with g-C3N4 biohybrid. The findings of this study suggest that g-C3N4-HKUST-1 is a highly efficient catalytic material for biocathodes in MESs to significantly enhance the CO2 conversion.
This article focuses on the area of software development for microcontrollers and details the implementation of modern programming practices and principles in embedded systems and IoT applications. This article explains how we implemented previously unimplemented principles and applied design patterns for quality software design on microcontrollers, which are currently only used for developing applications on the higher layers of the IoT reference model. A custom modular framework for microcontrollers is presented, based on applying SOLID principles and adapting design patterns specific to the microcontrollers' application development needs. The implemented framework enables independent communication between modules and flexible integration of hardware components. It is designed with platform independence in mind, contributing to its wide adaptability and ease of use in diverse development environments. By applying these technological approaches, we can create applications that are not only testable and extensible in terms of application logic but also allow for easy adaptation to changes in these hardware resources. Utilizing these capabilities represents an innovative approach to development for microcontrollers that fundamentally improves the long-term sustainability and scalability of applications.
- Klíčová slova
- IoT, SOLID, design pattern, framework, microcontroller, programming,
- Publikační typ
- časopisecké články MeSH
Energy resources are vital for the economic development of any nation, and they are currently recognised as an essential commodity for human beings. Many countries are facing various levels up to severe energy crisis due to limited natural resources, coupled with the Covid-19 pandemic. This crisis can lead to the shutdown or restriction of many industrial units, limited energy access, exacerbating unemployment, simultaneous impacts on people's lives. The main reason for these problems is the increasing gap between energy supply and demand, logistics, financial issues, as well as ineffective strategic planning issues. Different countries have different visions, missions, and strategies for energy management. Integrated strategic management is requisite for managing global energy. This study aims to develop a strategic management framework that can be used as a methodology for policymakers to analyse, plan, implement, and evaluate the energy strategy globally. A conceptual research method that relies on examining the related literature is applied to develop the framework. The present study yielded two main observations: 1) The identification of key concepts to consider in designing the strategic management framework for global energy, and 2) A strategic management framework that integrates the scope, process, important components, and steps to manage global energy strategies. This framework would contribute to providing a standard procedure to manage energy strategies for policymakers at the global, regional, national, state, city, district, and sector levels.
- Klíčová slova
- COVID-19, Conceptual methods, Energy crisis, Energy management, Energy management framework, Global energy, Strategic management,
- Publikační typ
- časopisecké články MeSH
Ibuprofen is one of the most widely used pharmaceuticals, and due to its inefficient removal by conventional wastewater treatment, it can be found in natural surface waters at high concentrations. Recently, we demonstrated that the TpBD-(CF3)2 covalent organic framework (COF) can adsorb ibuprofen from ultrapure water with high efficiency. Here, we investigate the performance of the COF for the extraction of ibuprofen from natural water samples from a lake, river, and estuary. In general, the complexity of the natural water matrix induced a reduction in the adsorption efficiency of ibuprofen as compared to ultrapure water. The best performance, with over 70% adsorption efficiency, was found in lake water, the sample which featured the lowest pH. According to the theoretical calculations, ibuprofen more favorably interacts with the COF pores in the protonated form, which could partially account for the enhanced adsorption efficiency found in lake water. In addition, we explored the effect of the presence of competing pharmaceuticals, namely, acetaminophen and phenobarbital, on the ibuprofen adsorption as binary mixtures. Acetaminophen and phenobarbital were adsorbed by TpBD-(CF3)2 with low efficiency and their presence led to an increase in ibuprofen adsorption in the binary mixtures. Overall, this study demonstrates that TpBD-(CF3)2 is an efficient adsorbent for the extraction of ibuprofen from natural waters as well.
- Klíčová slova
- adsorption, covalent organic frameworks, environmental water samples, pharmaceutical pollutants,
- MeSH
- adsorpce MeSH
- chemické látky znečišťující vodu chemie izolace a purifikace MeSH
- čištění vody * MeSH
- fenobarbital chemie izolace a purifikace MeSH
- ibuprofen chemie izolace a purifikace MeSH
- porézní koordinační polymery chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chemické látky znečišťující vodu MeSH
- fenobarbital MeSH
- ibuprofen MeSH
- porézní koordinační polymery MeSH
BACKGROUND: A core evaluation framework that captures the health care and societal benefits of value added medicines (VAMs, also often called repurposed medicines) was proposed in Report 1, aiming to reduce the heterogeneity in value assessment processes across countries and to create incentives for manufacturers to invest into incremental innovation. However, this can be impactful only if the framework can be adapted to heterogeneous health care financing systems in different jurisdictions, and the cost of evidence generation necessitated by the framework takes into account the anticipated benefits for the health care system and rewards for the developers. AREAS COVERED: The framework could potentially improve the pricing and reimbursement decisions of VAMs by adapting it to different country specific decision-contexts such as deliberative processes, augmented cost-effectiveness frameworks or formal multi-criteria decision analysis (MCDA); alternatively, some of its domains may be added to current general evaluation frameworks of medicines. The proposed evaluation framework may provide a starting point for practices based on which VAMs can be exempted from generic pricing mechanisms or can be integrated into the reimbursement and procurement system, allowing for price differentiation according to their added value. Besides evidence from RCTs, pricing and reimbursement decision processes of VAMs should allow for ex-ante non-RCT evidence for certain domains. Alternatively, relying on ex-post evidence agreements-such as outcome guarantee or coverage with evidence development-can also reduce decision uncertainty. CONCLUSIONS: The core evaluation framework for VAMs could trigger changes in the existing pricing, reimbursement and procurement practices by improving the appraisal of the added value created by incremental innovation.
- Klíčová slova
- Drug repurposing, Evidence, Generic reference pricing, Incremental innovation, Multi-criteria decision analysis, Value assessment framework, Value-added medicines,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Current energy and environmental challenges demand the development and design of multifunctional porous materials with tunable properties for catalysis, water purification, and energy conversion and storage. Because of their amenability to de novo reticular chemistry, metal-organic frameworks (MOFs) have become key materials in this area. However, their usefulness is often limited by low chemical stability, conductivity and inappropriate pore sizes. Conductive two-dimensional (2D) materials with robust structural skeletons and/or functionalized surfaces can form stabilizing interactions with MOF components, enabling the fabrication of MOF nanocomposites with tunable pore characteristics. Graphene and its functional derivatives are the largest class of 2D materials and possess remarkable compositional versatility, structural diversity, and controllable surface chemistry. Here, we critically review current knowledge concerning the growth, structure, and properties of graphene derivatives, MOFs, and their graphene@MOF composites as well as the associated structure-property-performance relationships. Synthetic strategies for preparing graphene@MOF composites and tuning their properties are also comprehensively reviewed together with their applications in gas storage/separation, water purification, catalysis (organo-, electro-, and photocatalysis), and electrochemical energy storage and conversion. Current challenges in the development of graphene@MOF hybrids and their practical applications are addressed, revealing areas for future investigation. We hope that this review will inspire further exploration of new graphene@MOF hybrids for energy, electronic, biomedical, and photocatalysis applications as well as studies on previously unreported properties of known hybrids to reveal potential "diamonds in the rough".
- MeSH
- elektrická vodivost MeSH
- elektronika MeSH
- grafit * MeSH
- katalýza MeSH
- porézní koordinační polymery * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- grafit * MeSH
- porézní koordinační polymery * MeSH
BACKGROUND: Medicines that are based on known molecules and are further developed to address healthcare needs and deliver relevant improvement for patients, healthcare professionals and/or payers are called value-added medicines (VAMs). The evaluation process of VAMs is heterogeneous across countries, and it has been primarily designed for originator pharmaceuticals with confirmatory evidence collected alongside pivotal clinical trials. There is a mismatch between evidence requirements by public decision-makers and evidence generated by manufacturers of VAMs. Our objective was to develop a core evaluation framework for VAMs. METHODS: Potential benefits offered by VAMs were collected through a systematic literature review and allocated to separate domains in an iterative process. The draft list of domains and their applicability were validated during two consecutive virtual workshops by health policy experts representing countries with different economic statuses, geographical and decision-making contexts. RESULTS: Based on 158 extracted studies, the final consensus on the evaluation framework resulted in 11 value domains in 5 main clusters, including unmet medical needs, health gain (measured by health care professionals), patient-reported outcomes, burden on households, and burden on the health care system. CONCLUSIONS: The proposed framework could reduce the heterogeneity in value assessment processes across countries and create incentives for manufacturers to invest in incremental innovation. However, some domains may not be equally relevant or accepted in all countries, therefore the core framework needs thorough adaptation in specific jurisdictions.
- Klíčová slova
- Expert panel, Generic price erosion, Incremental innovation, Repurposed medicine, Value assessment framework, Value domain, Value proposition, Value-added medicines,
- Publikační typ
- časopisecké články MeSH
Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption, and tight junction (TJ) proteins loss. Excess of H2 S in the intestinal milieu produced by the sulfate-reducing bacteria metabolism contributes to development of IBDs via epithelial barrier breakdown. Conventional interventions, such as surgery and anti-inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated Zr-based metal-organic framework (UiO-66) with a Cux -rhodamine B (CR) probe (hereinafter referred to as HUR), is produced via a co-flow microfluidic approach with the ability to reduce H2 S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO-66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration, and TJ proteins upregulation via H2 S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR is verified to be a promising theranostic platform able to decrease the H2 S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.
- Klíčová slova
- Zr metal-organic frameworks, hydrogen sulfide scavenging, inflammatory bowel disease, intestinal milieu restoration, microfluidic technology,
- MeSH
- mikrofluidika MeSH
- porézní koordinační polymery * metabolismus MeSH
- střeva MeSH
- střevní sliznice metabolismus MeSH
- sulfan chemie MeSH
- těsný spoj MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- porézní koordinační polymery * MeSH
- sulfan MeSH
- UiO-66 MeSH Prohlížeč
Cuby is a computational chemistry framework written in the Ruby programming language. It provides unified access to a wide range of computational methods by interfacing external software and it implements various protocols that operate on their results. Using structured input files, elementary calculations can be combined into complex workflows. For users, Cuby provides a unified and userfriendly way to automate their work, seamlessly integrating calculations carried out in different computational chemistry programs. For example, the QM/MM module allows combining methods across the interfaced programs and the builtin molecular dynamics engine makes it possible to run a simulation on the resulting potential. For programmers, it provides high-level, object-oriented environment that allows rapid development and testing of new methods and computational protocols. The Cuby framework is available for download at http://cuby4.molecular.cz. © 2016 Wiley Periodicals, Inc.
- Klíčová slova
- QM/MM, Ruby, datasets, software framework, workflow automation,
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The template preparation of hydroxyapatit (HAp) layered lanthanum-benzene tricarboxylic acid based metal organic frameworks (La-BTC MOFs) abbreviated as HAp-La-BTC-MOFs has been investigated here for defluoridation of water. The nucleation and growth of La-based MOFs was carried out in the prepared HAp hard template using layer-by-layer (LBL) technique. The coulomb and chelation contacts on HAp surface between Ca2+ ions and COO- organic ligands of La-BTC MOFs play vital roles in the preparation process. The batch experiments were employed to assess the defluoridation capacity (DC) of HAp-La based MOFs. The physicochemical properties of HAp-La based MOFs were investigated by various instrumentation techniques. To identify the nature, order and feasibility of HAp-La based MOFs towards defluoridation was examined by adsorption kinetics, isotherms and thermodynamics studies. The mechanism of defluoridation using HAp-La based MOFs were explained in detail. The field and reusability investigations of HAp-La-BTC MOFs also explored to find the potential applicability.
- Klíčová slova
- Defluoridation, Hydroxyapatite, Lanthanum, Metal organic frameworks, Reuse,
- MeSH
- adsorpce MeSH
- hydroxyapatit * chemie MeSH
- lanthan chemie MeSH
- porézní koordinační polymery * chemie MeSH
- termodynamika MeSH
- voda chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- hydroxyapatit * MeSH
- lanthan MeSH
- porézní koordinační polymery * MeSH
- voda MeSH
