• MeSH
• alergeny imunologie   MeSH
• alergie diagnóza   MeSH
• diagnostické testy rutinní MeSH
• fosfolipasy A imunologie   MeSH
• hmyzí proteiny imunologie   MeSH
• hyaluronoglukosaminidasa imunologie   MeSH
• imunoanalýza MeSH
• imunoglobulin E metabolismus   MeSH
• kožní testy MeSH
• lidé MeSH
• mladiství MeSH
• senioři MeSH
• senzitivita a specificita MeSH
• sérologie MeSH
• včelí jedy imunologie   MeSH
• včely imunologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• alergeny MeSH
• Api m 1 allergen, Apis mellifera MeSH Prohlížeč
• Api m 2 allergen, Apis mellifera MeSH Prohlížeč
• fosfolipasy A MeSH
• hmyzí proteiny MeSH
• hyaluronoglukosaminidasa MeSH
• imunoglobulin E MeSH
• včelí jedy MeSH

Seroprevalence data on viral hepatitis in the general population vary widely. The aim of this study was to determine the prevalence of hepatitis A (HAV), hepatitis B (HBV) and hepatitis C (HCV) viruses in the general Croatian adult population undergoing routine check-ups. The seroprevalence of anti-HAV, anti-HBc and anti-HCV was 40.5%, 7.0% and 0.9%, respectively. HBsAg was found in 0.7% and anti-HBs antibodies in 24.4% of participants. Gender was not associated with HAV, HBV or HCV seropositivity. HAV and HBV seropositivity increased progressively with age (HAV from 11.7% to 90.4%, p < 0.001; HBV from 1.7% to 15.8%, p < 0.001). Participants from rural areas showed a significantly higher HBV seroprevalence rate than those from urban areas (10.7% vs. 6.1%, p = 0.007). Results of univariate and multiple logistic regression showed that older age was a significant predictor for both HAV and HBV seropositivity while rural place of residence was a significant predictor for HBV seropositivity.

• MeSH
• diagnostické testy rutinní MeSH
• dospělí MeSH
• fyzikální vyšetření metody   MeSH
• hepatitida A - protilátky krev   imunologie   MeSH
• hepatitida B - protilátky krev   imunologie   MeSH
• hepatitida C - protilátky krev   imunologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• prevalence MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• séroepidemiologické studie MeSH
• virová hepatitida u lidí krev   epidemiologie   imunologie   MeSH
• zdraví ve městech statistika a číselné údaje   MeSH
• zdraví venkovských oblastí statistika a číselné údaje   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Chorvatsko epidemiologie   MeSH
• Názvy látek
• hepatitida A - protilátky MeSH
• hepatitida B - protilátky MeSH
• hepatitida C - protilátky MeSH

BACKGROUND AND AIMS: COVID-19 pandemic has impacted on all endoscopy centers in the Czech Republic, that belongs to the most affected countries in the world. The aim of our study was to analyze all procedures following routine RT-PCR testing in our tertiary center during the peak of the pandemic. METHODS: We retrospectively analyzed all procedures performed from October 2020 to January 2021 after a new RT-PCR center had been set up. Main outcomes were type of scheduled procedure, indication, rate of therapeutic interventions and rate of new relevant and malignant findings. Comparison to the same period before the pandemic and SARS-CoV-2 infection in endoscopy staff are also reported. RESULTS: A total of 1,953 procedures were performed. 624 patients were referred with a negative RT-PCR test and the remaining 1,346 patients were tested in the new center. 1,293 negative tests led to 1,329 procedures. A new relevant finding was reported in 589 (44.3%), including new malignancy in 56 (4.2%). 53 patients tested positive (3.9%). There was a reduction by 9% in the number of all procedures compared to the same period before the pandemic and an increase in the number of screening colonoscopies and ERCP procedures. In the study period, 9 of 54 staff members contracted SARS-CoV-2 infection. CONCLUSIONS: Routine RT-PCR testing of patients scheduled for elective endoscopy during the peak of COVID-19 pandemic enabled us to essentially maintain our unit productivity, including activities such as screening colonoscopy, endoscopic resection and pancreatobiliary endoscopy.

• Klíčová slova
• coronavirus disease 2019 (COVID-19), digestive endoscopy, reverse transcription polymerase chain reaction (RT-PCR), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
• MeSH
• centra terciární péče MeSH
• COVID-19 * diagnóza   MeSH
• diagnostické testy rutinní MeSH
• gastrointestinální endoskopie * MeSH
• lidé MeSH
• pandemie * MeSH
• polymerázová řetězová reakce s reverzní transkripcí * MeSH
• retrospektivní studie MeSH
• testování na COVID-19 průkazem nukleové kyseliny MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

OBJECTIVE: The performance of automated control of inspired oxygen (A-FiO2) has been confirmed in dozens of studies but reports of routine use are limited. Broadly adopted in Poland, our aim is to share that experience. METHODS: We used a prospectively planned observational study of the performance, general use patterns, unit practices, and problems with A-FiO2, based on a web registry of case reports, complemented by surveys of subjective impressions. RESULTS: In 2019, a total of 92 A-FiO2 systems were in routine use in 38 centers. Of the 38 centers, 20 had agreed in 2013 to participate in the project. In these centers, A-FiO2 was applied in infants of all weights, but some centers restricted its use to weaning from oxygen and unstable infants. A cohort had reported their experience with each use (5/20 centers, 593 cases). A quarter of those infants were managed with a lower target range and three-quarters with alarms looser than European guidelines for manual SpO2 control. The perceived primary advantages of A-FiO2 were as follows: keeping the readings in the target range, reducing exposure to SpO2 extremes, reducing risk from nurse distraction, reducing workload, and reducing alarm fatigue. Practices did evolve with experience, including implementing changes in the alarm strategy, indications for use, and target range. The potential for over-reliance on automation was cited as a risk. There were a few reports of limited effectiveness (moderate 12/593 and poor 2/593). CONCLUSIONS: Automated oxygen control is broadly perceived by users as an improvement in controlling SpO2 with infrequent problems.

• Klíčová slova
• adoption of technology, automated oxygen control, neonatal care, oxygen control, routine use,
• Publikační typ
• časopisecké články MeSH

Association of trough imatinib plasma levels (IPL) with cytogenetic or molecular response to treatment in patients with chronic myeloid leukemia (CML) was repeatedly reported. We analyzed their value in the routine clinical setting in 131 patients with chronic phase CML in whom imatinib was applied as first- or second-line treatment. A total of 1,118 measurements were obtained by ultra-performance liquid chromatography-tandem mass spectrometry assay in patients treated with daily dose of imatinib ranging from 100 to 800 mg. Samples were obtained from 1 to 96 h after drug ingestion. High inter (36%) and intraindividual variability (9-33%) of IPL was observed. For analysis of correlation of IPL with treatment response, two sets of samples were selected according to the European LeukemiaNet (ELN) criteria. The first set consisted of 241 samples taken 24 ± 2 h after dosing in 54 patients, and the second one consisted of 329 samples taken 24 ± 4 h after imatinib ingestion in 84 patients. In both sets, only patients treated with 400 mg imatinib once daily for at least 18 months were included. From multiple measurements in individual patients, mean IPL were used. In both sets, we were not able to demonstrate a statistically significant correlation between IPL and response to treatment according to the ELN. We believe that this was due to the differences in patients' compliance, leukemia biology, and other variables that are difficult to eliminate in the routine clinical practice. The use of IPL for prognostic estimation in CML treatment outside the clinical trials is probably limited.

• MeSH
• benzamidy MeSH
• biochemická analýza krve MeSH
• biomarkery farmakologické analýza   krev   MeSH
• chronická myeloidní leukemie krev   diagnóza   farmakoterapie   metabolismus   MeSH
• diagnostické testy rutinní MeSH
• dospělí MeSH
• imatinib mesylát MeSH
• klinické laboratorní techniky MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• piperaziny analýza   krev   farmakokinetika   terapeutické užití   MeSH
• prediktivní hodnota testů MeSH
• prognóza MeSH
• protinádorové látky analýza   krev   farmakokinetika   terapeutické užití   MeSH
• pyrimidiny analýza   krev   farmakokinetika   terapeutické užití   MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• hodnotící studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• benzamidy MeSH
• biomarkery farmakologické MeSH
• imatinib mesylát MeSH
• piperaziny MeSH
• protinádorové látky MeSH
• pyrimidiny MeSH

Despite the wide occurrence of ritual behavior in humans and animals, much of its causal underpinnings, as well as evolutionary functions, remain unknown. A prominent line of research focuses on ritualization as a response to anxiogenic stimuli. By manipulating anxiety levels, and subsequently assessing their motor behavior dynamics, our recent study investigated this causal link in a controlled way. As an extension to our original argument, we here discuss 2 theoretical explanations of rituals-ritualized behavior and automated behavior-and their link to anxiety. We propose that investigating participant's locus of attention can discriminate between these 2 models.

• Klíčová slova
• anxiety, automated behavior, ritual, ritualized behavior, routine,
• Publikační typ
• časopisecké články MeSH

BACKGROUND: International comparisons of population birth data provide essential benchmarks for evaluating perinatal health policies. OBJECTIVES: This study aimed to describe routine national data sources in Europe by their ability to provide core perinatal health indicators. METHODS: The Euro-Peristat Network collected routine national data on a recommended set of core indicators from 2015 to 2021 using a federated protocol based on a common data model with 16 data items. Data providers completed an online questionnaire to describe the sources used in each country. We classified countries by the number of data items they provided (all 16, 15-14, < 14). RESULTS: A total of 29 out of the 31 countries that provided data responded to the survey. Routine data sources included birth certificates (15 countries), electronic medical records (EMR) from delivery hospitalisations (16 countries), direct entry by health providers (9 countries), EMR from other care providers (7 countries) and Hospital Discharge Summaries (7 countries). Completeness of population coverage was at least 98%, with 17 countries reporting 100%. These databases most often included mothers giving birth in the national territory, regardless of nationality or place of residence (24 countries), whereas others register births to residents only. In 20 countries, routine sources were linked, including linkage between birth and death certificates (16 countries). Countries providing all 16 items (n = 8) were more likely to use EMRs from delivery hospitalisations (100%) compared to 50% and 11% in countries with 15-14 items (n = 12) and < 14 items (n = 9), respectively. Linkage was also more common in these countries (100%) versus 75% and 56%, respectively. Other data source characteristics did not differ by the ability to provide data on core perinatal indicators. CONCLUSIONS: There are wide differences between countries in the data sources used to construct perinatal health indicators in Europe. Countries using EMR linking to other sources had the best data availability.

• Klíčová slova
• Europe, birth data, international comparisons, perinatal indicators, pregnancy,
• MeSH
• elektronické zdravotní záznamy statistika a číselné údaje   MeSH
• informační zdroje MeSH
• lidé MeSH
• novorozenec MeSH
• perinatální péče * statistika a číselné údaje   normy   MeSH
• rodné listy * MeSH
• rutinně sbírané zdravotní údaje * MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH

AIM: Routine vaccination is one of the most important preventive methods which is responsible for the decreasing trend of morbidity and mortality of vaccine preventable infectious diseases, their complications and sequelae. The impact of vaccination on declining trend of these diseases is well known and confirmed by a large number of epidemiological studies. In the Czech Republic, there is high vaccination coverage in regards to most vaccine preventable diseases. However, during the last decade proportion of parents refusing routine vaccination of their children due to different factors is increasing. The presented study evaluates current situation in the Czech Republic and describes the most significant factors in parents decision making. METHODS: The study was conducted between 1 July 2013 and 31 March 2014 as a questionnaire based survey (cross-sectional study). The questionnaire was created with multiple choice answers. Questions were addressed to parents or legal representatives of children aged 0-18 years. Types of questions were divided into several subgroups. The study was performed in the Czech Republic in two different districts of Prague and Zlín. RESULTS: In the sample size (n=480) we detected 11 parents who refused vaccination of 11 children (2.29%). The most often refused vaccines in the prevalence study were hexavaccine (1st dose) and measles, mumps and rubella vaccine (1st dose). The hexavaccine includes tetanic anatoxin, diphtheric anatoxin, acellular pertussis vaccine, conjugate vaccine against Haemophilus influenzae b, inactivated polio vaccine, and recombinant vaccine against viral hepatitis B. The measles, mumps, rubella vaccine contains live attenuated viruses of measles, mumps, rubella. CONCLUSION: We observed increasing trend of routine vaccination refusal in children during the last ten years (compared to situation in the year 2004, p<0.001). The most important factors associated with this progression were distrust to vaccination, fear of some vaccine components and fear of adverse reactions.

• Klíčová slova
• children, parents, refusal of vaccination, routine vaccination, vaccine preventable disease,
• MeSH
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• novorozenec MeSH
• odmítnutí terapie pacientem psychologie   MeSH
• předškolní dítě MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• rizikové faktory MeSH
• rodiče psychologie   MeSH
• vakcinace psychologie   MeSH
• Check Tag
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

Aim: To evaluate the effectiveness and safety of ixazomib-lenalidomide-dexamethasone (IRd) in relapsed/refractory multiple myeloma in routine clinical practice. Patients & methods: Patient-level data from the global, observational INSIGHT MM and the Czech Registry of Monoclonal Gammopathies were integrated and analyzed. Results: At data cut-off, 263 patients from 13 countries were included. Median time from diagnosis to start of IRd was 35.8 months; median duration of follow-up was 14.8 months. Overall response rate was 73%, median progression-free survival, 21.2 months and time-to-next therapy, 33.0 months. Ixazomib/lenalidomide dose reductions were required in 17%/36% of patients; 32%/30% of patients discontinued ixazomib/lenalidomide due to adverse events. Conclusion: The effectiveness and safety of IRd in routine clinical practice are comparable to those reported in TOURMALINE-MM1. Clinical trial registration: NCT02761187 (ClinicalTrials.gov).

Lay abstract Proteasome inhibitors are drugs used in multiple myeloma (MM), a blood cancer that develops from cells in the bone marrow. Ixazomib is the first oral proteasome inhibitor to be approved for use in MM, when given in combination with two other oral drugs, lenalidomide and dexamethasone, to adult patients who have received one prior therapy. Our study, which was conducted in routine clinical practice, found that the effectiveness and safety of ixazomib + lenalidomide + dexamethasone in previously treated MM patients were similar to those seen in the Phase III clinical trial on which approval was based. These findings are important because they suggest that MM patients in everyday practice can achieve the same benefits from this treatment as patients in clinical trials, despite often being in poorer health.

• Klíčová slova
• effectiveness, ixazomib, multiple myeloma, proteasome inhibitor, relapsed/refractory, routine clinical practice,
• MeSH
• chemorezistence MeSH
• dexamethason aplikace a dávkování   škodlivé účinky   MeSH
• doba přežití bez progrese choroby MeSH
• dospělí MeSH
• glycin aplikace a dávkování   škodlivé účinky   analogy a deriváty   MeSH
• lenalidomid aplikace a dávkování   škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lokální recidiva nádoru farmakoterapie   mortalita   MeSH
• mnohočetný myelom farmakoterapie   mortalita   patologie   MeSH
• prospektivní studie MeSH
• protokoly protinádorové kombinované chemoterapie aplikace a dávkování   škodlivé účinky   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• sloučeniny boru aplikace a dávkování   škodlivé účinky   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• pozorovací studie MeSH
• Názvy látek
• dexamethason MeSH
• glycin MeSH
• ixazomib MeSH Prohlížeč
• lenalidomid MeSH
• sloučeniny boru MeSH

Routine outcome monitoring (ROM) has become an increasingly utilized tool in therapeutic practice that has the potential to improve therapy outcomes. This study aimed to synthesize the findings of existing qualitative studies investigating how clinicians use ROM in their work with clients. A systematic search of qualitative studies on clinicians' experience with the use of ROM in mental health services was conducted via PsycInfo, PsycArticles, Medline, Web of Science, and Scopus databases. Qualitative meta-analysis was used to synthesize the finding of the primary studies. Forty-seven studies met the inclusion criteria. The analysis resulted in 21 meta-categories organized into six clusters, namely (1) obtaining clinically relevant information, (2) adapting treatment, (3) facilitating communication, (4) enhancing the therapeutic relationship, (5) facilitating change in clients, and (6) personalized usage of ROM. The meta-analysis revealed that clinicians utilized ROM in diverse ways, including both informational and communicational functions. From the clinicians' perspective, ROM was an element that, on the one hand, introduced additional structure and standardization in treatment and, on the other hand, allowed for greater flexibility and tailoring of treatment.

• Klíčová slova
• Clinicians’ perspective, In-session use, Qualitative meta-analysis, Routine outcome monitoring, Therapists’ experience,
• MeSH
• duševní poruchy terapie   MeSH
• hodnocení výsledků zdravotní péče MeSH
• komunikace MeSH
• kvalitativní výzkum MeSH
• lidé MeSH
• postoj zdravotnického personálu MeSH
• psychoterapeuti * MeSH
• psychoterapie * organizace a řízení   normy   MeSH
• služby péče o duševní zdraví organizace a řízení   normy   MeSH
• vztahy mezi zdravotnickým pracovníkem a pacientem MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• metaanalýza MeSH