Photodynamic effects of meso-tetra (4-sulfonatophenyl)porphine on human leukemia cells HEL and HL60, human lymphocytes and bone marrow progenitor cells
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9253201
DOI
10.1016/s1011-1344(97)00017-1
PII: S1011134497000171
Knihovny.cz E-resources
- MeSH
- Transplantation, Autologous methods MeSH
- Cell Division drug effects MeSH
- Bone Marrow Cells MeSH
- Photochemistry MeSH
- Photochemotherapy * MeSH
- Hematopoietic Stem Cells drug effects MeSH
- HL-60 Cells MeSH
- Leukemia MeSH
- Humans MeSH
- Lymphocytes drug effects MeSH
- Porphyrins pharmacology MeSH
- Radiation-Sensitizing Agents pharmacology MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Porphyrins MeSH
- Radiation-Sensitizing Agents MeSH
- tetraphenylporphine sulfonate MeSH Browser
Meso-tetra(4-sulfonatophenyl)porphine (TPPS4), in combination with a light dose of 14 J cm-2, has a profound negative effect on the proliferation and viability of leukemia cells HL60 (human promyelocytic leukemia) and HEL (human erythroleukemia), the viability of normal lymphocytes and the colony-forming activity of human bone marrow progenitor cells. However, normal leukocytes (monocytes, granulocytes) are, to a large extent, resistant to photodynamic treatment (PDT). Whilst DNA fragmentation suggesting apoptosis is induced in HL60 cells, accumulation in the interphase of the cell cycle (G0/G1, G2/M) is mainly operative in the TPPS4-mediated PDT of HEL cells. The "dark" effect of TPPS4 on the cell viability is below 15% up to a concentration of 40 microM.
References provided by Crossref.org
Prion Strains Differ in Susceptibility to Photodynamic Oxidation
