Dopamine D2 receptors and alpha1-adrenoceptors synergistically modulate locomotion and behavior of rats in a place avoidance task
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18279977
DOI
10.1016/j.bbr.2007.12.025
PII: S0166-4328(08)00012-0
Knihovny.cz E-resources
- MeSH
- Adrenergic alpha-Antagonists administration & dosage MeSH
- Receptors, Adrenergic, alpha-1 drug effects metabolism MeSH
- Analysis of Variance MeSH
- Dopamine Antagonists administration & dosage MeSH
- Association Learning drug effects physiology MeSH
- Receptor Cross-Talk physiology MeSH
- Rats MeSH
- Motor Activity drug effects physiology MeSH
- Rats, Long-Evans MeSH
- Prazosin administration & dosage MeSH
- Spatial Behavior drug effects physiology MeSH
- Receptors, Dopamine D2 drug effects metabolism MeSH
- Sulpiride administration & dosage MeSH
- Drug Synergism MeSH
- Avoidance Learning drug effects physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Environment MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adrenergic alpha-Antagonists MeSH
- Receptors, Adrenergic, alpha-1 MeSH
- Dopamine Antagonists MeSH
- Prazosin MeSH
- Receptors, Dopamine D2 MeSH
- Sulpiride MeSH
The processing of spatial information is the focus of interest for many cognitive neuroscientists. Approximately 10 years ago, a novel behavioral paradigm called active allothetic place avoidance (AAPA) was designed allowing the simultaneous assessment of locomotor and spatial behavior. The present study describes the effect of the combined treatment of Long-Evans rats with alpha1-adrenergic and D2 antagonists prazosin (1mg/kg and 2 mg/kg) and sulpiride (10 mg/kg and 30 mg/kg) on locomotion and avoidance behavior in the AAPA task. Results show that co-application of both drugs leads to disturbances in locomotion and avoidance in rats at the doses, which caused no impairments when administered independently. This finding suggests that both types of receptors act synergistically to regulate locomotion and possibly spatial behavior.
References provided by Crossref.org
Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders
Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation
