Models of schizophrenia in humans and animals based on inhibition of NMDA receptors
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
18471877
DOI
10.1016/j.neubiorev.2008.03.012
PII: S0149-7634(08)00050-X
Knihovny.cz E-resources
- MeSH
- Excitatory Amino Acid Antagonists pharmacology MeSH
- Adaptation, Physiological MeSH
- Ketamine pharmacology MeSH
- Humans MeSH
- Disease Models, Animal MeSH
- Models, Neurological MeSH
- Receptors, N-Methyl-D-Aspartate antagonists & inhibitors metabolism MeSH
- Schizophrenia metabolism physiopathology MeSH
- Psychoses, Substance-Induced metabolism physiopathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Excitatory Amino Acid Antagonists MeSH
- Ketamine MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
The research of the glutamatergic system in schizophrenia has advanced with the use of non-competitive antagonists of glutamate NMDA receptors (phencyclidine, ketamine, and dizocilpine), which change both human and animal behaviour and induce schizophrenia-like manifestations. Models based on both acute and chronic administration of these substances in humans and rats show phenomenological validity and are suitable for searching for new substances with antipsychotic effects. Nevertheless, pathophysiology of schizophrenia remains unexplained. In the light of the neurodevelopmental model of schizophrenia based on early administration of NMDA receptor antagonists it seems that increased cellular destruction by apoptosis or changes in function of glutamatergic NMDA receptors in the early development of central nervous system are decisive for subsequent development of psychosis, which often does not manifest itself until adulthood. Chronic administration of antagonists initializes a number of adaptation mechanisms, which correlate with findings obtained in patients with schizophrenia; therefore, this model is also suitable for research into pathophysiology of this disease.
References provided by Crossref.org
A new two-hit animal model for schizophrenia research: Consequences on social behavior
Open field test for the assessment of anxiety-like behavior in Gnathonemus petersii fish
The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research
