Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum
Language English Country Great Britain, England Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Bacterial Agents * pharmacology therapeutic use MeSH
- Drug Resistance, Bacterial genetics MeSH
- Child MeSH
- DNA, Bacterial analysis isolation & purification MeSH
- Adult MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Macrolides pharmacology therapeutic use MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mutation * MeSH
- Treatment Failure MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- RNA, Ribosomal, 23S genetics MeSH
- Sequence Analysis, DNA MeSH
- Spiramycin * pharmacology therapeutic use MeSH
- Syphilis drug therapy epidemiology microbiology MeSH
- Treponema pallidum drug effects genetics MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Anti-Bacterial Agents * MeSH
- DNA, Bacterial MeSH
- Macrolides MeSH
- RNA, Ribosomal, 23S MeSH
- Spiramycin * MeSH
We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.
References provided by Crossref.org
The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis
Complete genome sequence of Treponema pallidum strain DAL-1
