Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum
Language English Country England, Great Britain Media print
Document type Case Reports, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anti-Bacterial Agents * pharmacology therapeutic use MeSH
- Drug Resistance, Bacterial genetics MeSH
- Child MeSH
- DNA, Bacterial analysis isolation & purification MeSH
- Adult MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Macrolides pharmacology therapeutic use MeSH
- Adolescent MeSH
- Young Adult MeSH
- Mutation * MeSH
- Treatment Failure MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- RNA, Ribosomal, 23S genetics MeSH
- Sequence Analysis, DNA MeSH
- Spiramycin * pharmacology therapeutic use MeSH
- Syphilis drug therapy epidemiology microbiology MeSH
- Treponema pallidum drug effects genetics MeSH
- Animals MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Rabbits MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Infant, Newborn MeSH
- Child, Preschool MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Anti-Bacterial Agents * MeSH
- DNA, Bacterial MeSH
- Macrolides MeSH
- RNA, Ribosomal, 23S MeSH
- Spiramycin * MeSH
We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.
References provided by Crossref.org
A new typing scheme demonstrates high discriminatory power for Treponema pallidum subspecies
The hare syphilis agent is related to, but distinct from, the treponeme causing rabbit syphilis
Complete genome sequence of Treponema pallidum strain DAL-1
