Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays and protons in action
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23415104
DOI
10.1016/j.apradiso.2013.01.022
PII: S0969-8043(13)00023-7
Knihovny.cz E-resources
- Keywords
- DNA double-strand breaks (DSBs), Formation of chromosomal translocations, Gamma rays and proton beams, Higher-order chromatin structure and DSB repair, γH2AX foci,
- MeSH
- Cell Nucleus radiation effects MeSH
- Chromatin chemistry MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Microscopy MeSH
- DNA Repair * MeSH
- DNA Damage * MeSH
- Protons * MeSH
- Translocation, Genetic MeSH
- Gamma Rays * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Chromatin MeSH
- Protons * MeSH
According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.
References provided by Crossref.org
Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change
In Vitro Comparison of Passive and Active Clinical Proton Beams
