According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.

Institute of Biophysics Brno Academy of Sciences of the Czech Republic Brno Czech Republic; Joint Institute for Nuclear Research Dubna Moscow Region Russia; Institute of Chemical Technology Prague Prague Czech Republic

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