Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review
PubMed
23664415
DOI
10.1016/j.tplants.2013.04.005
PII: S1360-1385(13)00065-4
Knihovny.cz E-resources
- Keywords
- actin, cytoskeleton, microtubules, phosphatidic acid, phospholipase D, signaling,
- MeSH
- Actins metabolism MeSH
- Cell Membrane metabolism MeSH
- Cytoskeleton metabolism MeSH
- Phospholipase D metabolism MeSH
- Stress, Physiological MeSH
- Plant Physiological Phenomena MeSH
- Phosphatidic Acids metabolism MeSH
- Microtubules metabolism MeSH
- Plant Proteins metabolism MeSH
- Plants enzymology MeSH
- Signal Transduction MeSH
- Protein Binding MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Names of Substances
- Actins MeSH
- Phospholipase D MeSH
- Phosphatidic Acids MeSH
- Plant Proteins MeSH
Plants respond to diverse biotic and abiotic stimuli as well as to endogenous developmental cues. Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). PA is a key signaling intermediate in animals, but its targets in plants are relatively uncharacterized. Recent studies have demonstrated that the cytoskeleton is a major target of PLD-PA signaling and identified a positive feedback loop between actin turnover and PLD activity. Moreover, two cytoskeletal proteins, capping protein and MAP65-1, have been identified as PA-binding proteins regulating actin and microtubule organization and dynamics. In this review, we highlight the role of the PLD-PA module as an important hub for housekeeping and stress-induced regulation of membrane-associated cytoskeletal dynamics.
References provided by Crossref.org
Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity
Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants
When fat is not bad: the regulation of actin dynamics by phospholipid signaling molecules
