Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- Keywords
- Alzheimer's diseases, acetylcholinesterase, donepezil, galantamine, memantine, rivastigmine,
- MeSH
- Alzheimer Disease drug therapy epidemiology physiopathology MeSH
- Excitatory Amino Acid Antagonists adverse effects pharmacology therapeutic use MeSH
- Cholinesterase Inhibitors adverse effects pharmacology therapeutic use MeSH
- Clinical Trials as Topic MeSH
- Humans MeSH
- Memantine adverse effects pharmacology therapeutic use MeSH
- Disease Progression MeSH
- Drug Design MeSH
- Treatment Outcome MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Excitatory Amino Acid Antagonists MeSH
- Cholinesterase Inhibitors MeSH
- Memantine MeSH
INTRODUCTION: Alzheimer's disease (AD) is a world-wide health problem with implications for an increasing number of people and countries. Populations suffering from AD financially strain the healthcare budgets of rich and poor countries alike. Moreover, no effective treatment is available and current drugs merely slow the progression of cognitive function deterioration and overall health status toward an inevitable end point. An increasing number of novel approaches have been tested in numerous clinical trials, but none of them has proved safe and effective for treating AD. AREAS COVERED: This review summarizes all currently available compounds (donepezil, rivastigmine, galantamine, memantine) for the management of AD, concentrating on clinical aspects such as the mechanisms of action, pharmacokinetics, pharmacodynamics and clinical trials. This review also considers the mechanisms and side effects to provide perspective on current treatment options. EXPERT OPINION: Novel approaches in the treatment of AD are being intensively tested, but so far without any major success. Patients diagnosed with AD still mostly benefit from four compounds to significantly improve cognition functions and overall health and help manage other symptoms or even prolong the symptom-free period.
References provided by Crossref.org
Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer's Disease
Profiling donepezil template into multipotent hybrids with antioxidant properties
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Alzheimer's disease and language impairments: social intervention and medical treatment