Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.

Department of Biology of the Cell Nucleus Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic Prague 14220 Czech Republic

Unidad de Bioquímica y Biología molecular de plantas Centro de Investigación Científica de Yucatán Colonia Chuburná de Hidalgo Mérida Yucatan Mexico

Unidad de Biotecnología Centro de Investigación Científica de Yucatán Colonia Chuburná de Hidalgo Mérida Yucatan Mexico

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Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids

Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana

Fibrillarin methylates H2A in RNA polymerase I trans-active promoters in Brassica oleracea