Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma
Language English Country Greece Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26820484
DOI
10.3892/or.2016.4599
Knihovny.cz E-resources
- MeSH
- Gene Expression * MeSH
- Middle Aged MeSH
- Humans MeSH
- Membrane Transport Proteins genetics MeSH
- Ovarian Neoplasms genetics pathology MeSH
- Pilot Projects MeSH
- Disease-Free Survival MeSH
- Prognosis MeSH
- Disease Progression MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Gene Expression Profiling methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Membrane Transport Proteins MeSH
Membrane transporters (such as ABCs, SLCs and ATPases) act in carcinogenesis and chemoresistance development, but their relevance for prognosis of epithelial ovarian cancer (EOC) remains poorly understood. We evaluated the gene expression profile of 39 ABC and 12 SLC transporters and three ATPases in EOC tissues and addressed their putative role in prognosis and clinical course of EOC patients. Relative gene expression in a set of primary EOC (n=57) and in control ovarian tissues (n=14) was estimated and compared with clinical data and survival of patients. Obtained data were validated in an independent set of patients (n=60). Six ABCs and SLC22A18 gene were significantly overexpressed in carcinomas when compared with controls, while expression of 12 ABCs, five SLCs, ATP7A and ATP11B was decreased. Expression of ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 was higher in high grade serous carcinoma compared with other subtypes. ABCA2 gene expression significantly associated with EOC grade in both sets of patients. Notably, expression level of ABCA9, ABCA10, ABCC9 and SLC16A14 significantly associated with progression-free survival (PFS) of the disease in either pilot or validation sets. ABCG2 level associated with PFS in the pooled set of patients. In conclusion, ABCA2, ABCA9, ABCA10, ABCC9, ABCG2 and SLC16A14 present novel putative markers of EOC progression and together with the revealed relationship between ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 expression, and high grade serous type of EOC should be further examined by larger follow-up study.
Biomedical Center Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic
Toxicogenomics Unit National Institute of Public Health Prague Czech Republic
References provided by Crossref.org
The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes
SLC46A1 Haplotype with Predicted Functional Impact has Prognostic Value in Breast Carcinoma
ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer
