Non-canonical transcription initiation: the expanding universe of transcription initiating substrates
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
27799279
DOI
10.1093/femsre/fuw041
PII: fuw041
Knihovny.cz E-zdroje
- Klíčová slova
- RNA polymerase, RNA stability, coenzymes, nicotinamide adenine dinucleotide (NAD+), non-canonical transcription initiation, transcription initiating substrate,
- MeSH
- iniciace genetické transkripce fyziologie MeSH
- koenzymy MeSH
- oligonukleotidy MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- koenzymy MeSH
- oligonukleotidy MeSH
RNA polymerase (RNAP) is the central enzyme of transcription of the genetic information from DNA into RNA. RNAP recognizes four main substrates: ATP, CTP, GTP and UTP. Experimental evidence from the past several years suggests that, besides these four NTPs, other molecules can be used to initiate transcription: (i) ribooligonucleotides (nanoRNAs) and (ii) coenzymes such as NAD+, NADH, dephospho-CoA and FAD. The presence of these molecules at the 5΄ ends of RNAs affects the properties of the RNA. Here, we discuss the expanding portfolio of molecules that can initiate transcription, their mechanism of incorporation, effects on RNA and cellular processes, and we present an outlook toward other possible initiation substrates.
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