In Vitro Antistaphylococcal Synergistic Effect of Isoflavone Metabolite Demethyltexasin with Amoxicillin and Oxacillin
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28570834
DOI
10.1089/mdr.2017.0033
Knihovny.cz E-zdroje
- Klíčová slova
- antibiotic resistance, antimicrobial combinatory effect, checkerboard method, β-lactam antibiotics,
- MeSH
- amoxicilin farmakologie MeSH
- antibakteriální látky farmakologie MeSH
- fixní kombinace léků MeSH
- isoflavony farmakologie MeSH
- kombinace amoxicilinu a kyseliny klavulanové farmakologie MeSH
- lidé MeSH
- methicilin rezistentní Staphylococcus aureus účinky léků růst a vývoj MeSH
- mikrobiální testy citlivosti MeSH
- oxacilin farmakologie MeSH
- rezistence na methicilin účinky léků MeSH
- Staphylococcus aureus účinky léků růst a vývoj MeSH
- synergismus léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 6,7,4'-trihydroxyisoflavone MeSH Prohlížeč
- amoxicilin MeSH
- antibakteriální látky MeSH
- fixní kombinace léků MeSH
- isoflavony MeSH
- kombinace amoxicilinu a kyseliny klavulanové MeSH
- oxacilin MeSH
Staphylococcal infections are often hard to treat due to increasing resistance, especially to β-lactams. Previous studies described the synergy between common antibiotics and isoflavonoids; however, little is yet known about the combinatory effects of antibiotics with products of human isoflavone metabolism. In this study, demethyltexasin (DT), a human body metabolite of soybean isoflavones, was evaluated for its possible antistaphylococcal combinatory effect with amoxicillin and oxacillin. For comparison, common therapeutically used combination of amoxicillin/clavulanic acid was tested. DT showed strong synergistic interactions against most of Staphylococcus aureus strains when combined with amoxicillin (sum of fractional inhibitory concentrations [ΣFIC] 0.257-0.461) and oxacillin (ΣFIC 0.109-0.484). When oxacillin was combined with DT, resistance to this antibiotic was overcome in many cases. Moreover, antibiotic/DT combinations were effective mainly against methicillin-resistant S. aureus (MRSA); however, the commonly used drug amoxicillin/clavulanic acid was effective only against sensitive strains. Our results indicated DT as a compound able to act synergistically with β-lactams. In addition, some combinations are effective against MRSA and decrease staphylococcal resistance. To the best of our knowledge this is the first report of the antimicrobial synergistic effects of isoflavone human body metabolite with common antibiotics. DT seems to be a possible candidate for further research focused on antistaphylococcal drug development, especially against antibiotic-resistant strains.
Citace poskytuje Crossref.org
