Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
30588615
DOI
10.1002/cpt.1341
Knihovny.cz E-zdroje
- MeSH
- bilirubin biosyntéza MeSH
- diabetes mellitus 2. typu prevence a kontrola MeSH
- Gilbertova nemoc patofyziologie MeSH
- glukuronosyltransferasa genetika MeSH
- hyperbilirubinemie epidemiologie genetika patofyziologie MeSH
- kardiovaskulární nemoci prevence a kontrola MeSH
- lidé MeSH
- mediátory zánětu antagonisté a inhibitory MeSH
- metabolický syndrom prevence a kontrola MeSH
- oxidační stres fyziologie MeSH
- sexuální faktory MeSH
- stupeň závažnosti nemoci MeSH
- věkové faktory MeSH
- životní styl MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- bilirubin MeSH
- glukuronosyltransferasa MeSH
- mediátory zánětu MeSH
- UGT1A1 enzyme MeSH Prohlížeč
Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic syndrome. In mammals, bilirubin plays a major role as a potent antioxidant. Uridine 5'-diphospho-glucuronosyl transferase (UGT)1A1 variants coding for bilirubin UDP-glucuronosyl transferase resulting in mild hyperbilirubinemia (as in Gilbert syndrome (GS)) may confer a strong genetic advantage. Strategies to boost bioavailability of bilirubin or to mimic GS represent an attractive approach to prevent many oxidative stress and inflammation-mediated diseases. Even a tiny, micromolar increase in serum bilirubin concentrations substantially decreases the risk of oxidative stress-mediated diseases. There are several possible ways to achieve this, including lifestyle changes, changes in dietary patterns, regular physical activities, or use of chemical drug or of specific plant products either in the form of regular food items or nutraceuticals. Further basic and experimental research is required to fully uncover this promising therapeutic field.
Citace poskytuje Crossref.org
The physiology of bilirubin: health and disease equilibrium
Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect
