Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
30588615
DOI
10.1002/cpt.1341
Knihovny.cz E-resources
- MeSH
- Bilirubin biosynthesis MeSH
- Diabetes Mellitus, Type 2 prevention & control MeSH
- Gilbert Disease physiopathology MeSH
- Glucuronosyltransferase genetics MeSH
- Hyperbilirubinemia epidemiology genetics physiopathology MeSH
- Cardiovascular Diseases prevention & control MeSH
- Humans MeSH
- Inflammation Mediators antagonists & inhibitors MeSH
- Metabolic Syndrome prevention & control MeSH
- Oxidative Stress physiology MeSH
- Sex Factors MeSH
- Severity of Illness Index MeSH
- Age Factors MeSH
- Life Style MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Bilirubin MeSH
- Glucuronosyltransferase MeSH
- Inflammation Mediators MeSH
- UGT1A1 enzyme MeSH Browser
Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic syndrome. In mammals, bilirubin plays a major role as a potent antioxidant. Uridine 5'-diphospho-glucuronosyl transferase (UGT)1A1 variants coding for bilirubin UDP-glucuronosyl transferase resulting in mild hyperbilirubinemia (as in Gilbert syndrome (GS)) may confer a strong genetic advantage. Strategies to boost bioavailability of bilirubin or to mimic GS represent an attractive approach to prevent many oxidative stress and inflammation-mediated diseases. Even a tiny, micromolar increase in serum bilirubin concentrations substantially decreases the risk of oxidative stress-mediated diseases. There are several possible ways to achieve this, including lifestyle changes, changes in dietary patterns, regular physical activities, or use of chemical drug or of specific plant products either in the form of regular food items or nutraceuticals. Further basic and experimental research is required to fully uncover this promising therapeutic field.
References provided by Crossref.org
The physiology of bilirubin: health and disease equilibrium
Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes
Chirality Matters: Biological Activity of Optically Pure Silybin and Its Congeners
The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect
