Cholesterol 24-Hydroxylase [cholesterol-24-hydroxylasa]

topical
Terms

cholestantetrol-24-hydroxylasa
cholesterol-24-hydroxyláza
CYP46A1
cytochrom P450 46A1

 

5(beta)-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol-24S-hydroxylase
Brain-Specific 24S-Hydroxylase
Cholestane Tetrol 24-Hydroxylase
CYP46A1
Cytochrome P450 46A1

Definition

A steroid hydroxylase that functions in CHOLESTEROL homeostasis in the brain. It converts cholesterol into 24S-hydroxycholesterol, which is transported over the BLOOD-BRAIN BARRIER more rapidly than unmetabolized cholesterol.

DUI
D000072556 MeSH Browser
CUI
M0333121
History note
2017 (1999)
Public note
2017; CHOLESTEROL 24-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1999-2016

D Chemicals and Drugs
D08.244 Cytochromes 121
D08.244.453.875.500 Cholesterol 24-Hydroxylase
D08.244.453.915 Steroid Hydroxylases 16
D08.244.453.915.025 Cholesterol 24-Hydroxylase
D08.244.453.915.050 Cytochrome P-450 CYP11B2 11
D08.244.453.915.099 Aromatase 72
D08.244.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.244.453.915.730 Steroid 12-alpha-Hydroxylase 1
D08.244.453.915.737 Steroid 16-alpha-Hydroxylase 5
D08.244.453.915.748 Steroid 17-alpha-Hydroxylase 21
D08.244.453.915.750 Steroid 11-beta-Hydroxylase 3
D08.244.453.915.760 Steroid 21-Hydroxylase 63
D08.244.453.915.880 Sterol 14-Demethylase 2
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.690 Oxygenases 76
D08.811.682.690.708 Mixed Function Oxygenases 68
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System 692
D08.811.682.690.708.170.497 Cytochrome P450 Family 46
D08.811.682.690.708.170.497.500 Cholesterol 24-Hydroxylase
D08.811.682.690.708.170.915 Steroid Hydroxylases 16
D08.811.682.690.708.170.915.025 Cholesterol 24-Hydroxylase
D08.811.682.690.708.170.915.050 Cytochrome P-450 CYP11B2 11
D08.811.682.690.708.170.915.099 Aromatase 72
D08.811.682.690.708.170.915.150 Cholestanetriol 26-Monooxygenase 4
D08.811.682.690.708.170.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.811.682.690.708.170.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.811.682.690.708.170.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.811.682.690.708.170.915.730 Steroid 12-alpha-Hydroxylase 1
D08.811.682.690.708.170.915.737 Steroid 16-alpha-Hydroxylase 5
D08.811.682.690.708.170.915.748 Steroid 17-alpha-Hydroxylase 21
D08.811.682.690.708.170.915.750 Steroid 11-beta-Hydroxylase 3
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase 63
D08.811.682.690.708.170.915.880 Sterol 14-Demethylase 2
D12.776 Proteins 2 577
D12.776.422 Hemeproteins 16
D12.776.422.220 Cytochromes 121
D12.776.422.220.453 Cytochrome P-450 Enzyme System 692
D12.776.422.220.453.875 Cytochrome P450 Family 46
D12.776.422.220.453.875.500 Cholesterol 24-Hydroxylase
D12.776.422.220.453.915 Steroid Hydroxylases 16
D12.776.422.220.453.915.025 Cholesterol 24-Hydroxylase
D12.776.422.220.453.915.050 Cytochrome P-450 CYP11B2 11
D12.776.422.220.453.915.099 Aromatase 72
D12.776.422.220.453.915.150 Cholestanetriol 26-Monooxygenase 4
D12.776.422.220.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D12.776.422.220.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D12.776.422.220.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D12.776.422.220.453.915.730 Steroid 12-alpha-Hydroxylase 1
D12.776.422.220.453.915.737 Steroid 16-alpha-Hydroxylase 5
D12.776.422.220.453.915.748 Steroid 17-alpha-Hydroxylase 21
D12.776.422.220.453.915.750 Steroid 11-beta-Hydroxylase 3
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase 63
D12.776.422.220.453.915.880 Sterol 14-Demethylase 2