Retinoblastoma Protein [retinoblastomový protein]
- Terms
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protein p105-Rb
Rb protein
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p105-Rb Protein
Rb Gene Product
Rb Protein
Rb1 Gene Product
Retinoblastoma Nuclear Phosphoprotein p105-Rb
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
- Annotation
- /biosyn /drug eff /physiol /ultrastruct permitted
- DUI
- D016160 MeSH Browser
- CUI
- M0024673
- Previous indexing
- Phosphoproteins (1990)
- History note
- 91
- Public note
- 91
Allowable subheadings
- AD
- administration & dosage
- AE
- adverse effects
- AG
- agonists
- AN
- analysis 3
- AI
- antagonists & inhibitors 2
- BI
- biosynthesis 2
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry 1
- CL
- classification
- DF
- deficiency 1
- DE
- drug effects 1
- EC
- economics
- GE
- genetics 12
- HI
- history
- IM
- immunology
- IP
- isolation & purification 1
- ME
- metabolism 28
- PK
- pharmacokinetics
- PD
- pharmacology 1
- PH
- physiology 11
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
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