Sterol 14-Demethylase [sterol-14-demethylasa]
- Terms
-
cytochrom P-450 CYP51
lanosterol-14-alfa-demethylasa
sterol-14-demetyláza
-
CYP51 Cytochrome P-450
Cytochrome P-450 CYP51
Eburicol 14 alpha-Demethylase
Eburicol 14alpha-Demethylase
Lanosterol 14 alpha-Demethylase
Obtusifoliol 14alpha-Demethylase
Sterol 14-alpha-Demethylase
Sterol 14-Demethylases
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
- DUI
- D058886 MeSH Browser
- CUI
- M0545190
- History note
- 2011
- Public note
- 2011; STEROL 14-DEMETHYLASE was indexed under CYTOCHROME P-450 ENZYME SYSTEM 2009-2010, under OXIDOREDUCTASES 1978-2008, & under LANOSTEROL 1976-1982
Combination
- antagonists & inhibitors
- 14-alpha Demethylase Inhibitors
Allowable subheadings
- AD
- administration & dosage 1
- AE
- adverse effects 1
- AN
- analysis
- BI
- biosynthesis
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DF
- deficiency
- DE
- drug effects
- EC
- economics
- GE
- genetics 1
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 1
- PD
- pharmacology 1
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 1
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
CYP51A1 protein, human Chemical MeSH Browser
Cyp51 protein, mouse Chemical MeSH Browser
Cyp51 protein, rat Chemical MeSH Browser