Příspěvek obsahuje český překlad doporučení European consensus guidelines on the management of respiratory distress syndrome ohledně používání oxygenoterapie u nezralých novorozenců, doplněný o nové patofyziologické poznatky, na jejichž základě může v budoucnu dojít k úpravě a individualizaci používání oxygenoterapie podle gestačního stáří pacienta.
The following text is a Czech translation of the European consensus guidelines on the management of respiratory distress syndrome recommendations on oxygenotherapy in preterm infants, supplemented by emerging pathophysiological findings, which might necessitate an updated version of these recommendations to be released, stratified by gestational age.
- Klíčová slova
- postmenstruační věk,
- MeSH
- lidé MeSH
- novorozenec nedonošený MeSH
- novorozenec MeSH
- oxygenoterapie metody MeSH
- saturace kyslíkem * MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- směrnice pro lékařskou praxi MeSH
A significant aspermatogenic activity, ascertained by microscopic studies of seminiferous tubules and interstitial tissue, and by the observation of the entrance of immunity and fibrocytic cells in mice injected with polyspermine (PS) or polyspermine conjugated to monomeric or dimeric RNase A (PS-RNase A or PS-dimeric RNase A, respectively), was found either in mice injected or in non-injected testes. Polyspermine and its complexes with RNase A destroyed all spermatogenic and intertestitial tissue, including Leydic cells, as well as their ability to secrete testosterone. The total loss of spermatogenic activity in injected testes is irreversible because spermatogonia cells also were destroyed. The injection of PS into both mice testes determined the total degeneration of testicle tissue in 50% of injected testes. The second half of testes was also partly degenerated, and if they were re-injected, almost all testes were fully destroyed. PS-dimeric RNase A injected once into both testicles produced a stronger degeneration and also the interruption of testosterone secretion in comparison with the effects due to injection of mice with PS or PS-RNase A. In all mice treated with these substances, as well as in rats in which PS was injected twice into their testes, we detected polymorfonucleates, monocytes, plasma cells, lymphocytes.and fibrocytic cells. Antibodies against PS, PS-RNase A or PS-dimeric RNase A did not influence the aspermatogenic activity. Animals in which a repeated intra-peritoneal injection was carried out did not lose body mass and remained in good condition, with the exception of mice injected with spermine.
- MeSH
- antispermatogenní látky farmakologie MeSH
- buňky imunologie patologie účinky léků MeSH
- financování organizované využití MeSH
- interpretace statistických dat MeSH
- myši inbrední ICR MeSH
- potkani Wistar MeSH
- ribonukleasy genetika imunologie účinky léků MeSH
- spermatogeneze genetika imunologie účinky léků MeSH
- spermin farmakologie škodlivé účinky MeSH
- testis imunologie patologie účinky léků MeSH
