Autoimmune uveitis is a serious sightthreatening disease that in many cases fails to respond to conventional immunosuppressive or biological therapy. Experimental models used in research allow more detailed study of pathogenesis of the autoimmune process and testing new therapeutic strategies. Recent results show that infection can trigger autoimmune diseases, and some commensal microorganisms are essential in causing disease activity. The aim of this work was to assess the effect of broadspectrum antibiotics - combination of metronidazole and ciprofloxacin or metronidazole alone - on the intensity of intraocular inflammation in experimental autoimmune uveitis (EAU). EAU was induced in mouse strain C57BL/6J by interphotoreceptor retinoid- binding protein in complete Freund's adjuvant and pertussis toxin. The grade of uveitis was assessed clinically and histologically in haematoxylin and eosin- stained tissues. Lymphocytes and macrophages were detected in cryosections using the immunoperoxidase method with antibodies. The therapy was commenced one week before EAU induction and continued throughout the experiment. In addition, metronidazole treatment was also started two weeks before EAU induction. Antibiotics significantly reduced the intensity of uveitis compared to the control group (P < 0.05). The effects of combination of ciprofloxacin and metronidazole and of metronidazole alone were similar when the therapy started one week before EAU induction (P < 0.05). Metronidazole commenced two weeks before EAU induction and throughout the experiment suppressed the intensity of EAU with even higher statistical significance (P < 0.0001). It can be assumed that the high protective effect of metronidazole on EAU intensity may be due not only to its antimicrobial effect, but also to its immunomodulatory activity.
- MeSH
- ciprofloxacin farmakologie terapeutické užití MeSH
- metronidazol farmakologie terapeutické užití MeSH
- myši inbrední C57BL MeSH
- stupeň závažnosti nemoci MeSH
- uveitida komplikace farmakoterapie patologie MeSH
- zánět komplikace farmakoterapie patologie MeSH
- zvířata MeSH
- Check Tag
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- Fuchsova heterochromní iridocyklitida, posttraumatická uveitida, uveitida vyvolaná čočkou, Posnerův-Schlossmanův syndrom,
- MeSH
- Behcetův syndrom MeSH
- dítě MeSH
- dospělí MeSH
- granulomatóza s polyangiitidou MeSH
- HLA-B27 antigen MeSH
- idiopatické střevní záněty MeSH
- juvenilní artritida MeSH
- klinický obraz nemoci MeSH
- lidé MeSH
- oftalmologie MeSH
- přední uveitida * klasifikace MeSH
- psoriáza MeSH
- reaktivní artritida MeSH
- roztroušená skleróza MeSH
- sarkoidóza MeSH
- sympatická oftalmie MeSH
- uveitida * etiologie klasifikace MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- přehledy MeSH
Otoky víček patří k častým nálezům nejen v oftalmologické praxi. Jejich etiologie bývá často složitá a herpetické afekce patří k častým příčinám. Mnohdy vyžadují spolupráci oftalmologa a dermatologa.
Swelling of the eyelids appears to be a common symptom not only in Ophthalmology. The etiology is often complicated and herpetic affection is one of the most common causes. Collaboration of ophthalmologist and dermatologist is frequently required to make the right diagnosis.
- Klíčová slova
- varicella zoster virus, herpes simplex virus,
- MeSH
- edém MeSH
- herpes simplex diagnóza terapie virologie MeSH
- herpes zoster ophthalmicus diagnóza terapie virologie MeSH
- lidé MeSH
- nemoci očních víček etiologie klasifikace MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- přehledy MeSH
