- MeSH
- diabetes mellitus 1. typu metabolismus MeSH
- jod metabolismus moč nedostatek normy MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
There is a lack of data on the state of iodine reserves and the possible consequences of iodine deficits in diabetic patients. The main aims of this study were to: a) obtain information about iodine saturation in patients with type 1 diabetes; b) determine to what extent this saturation differs from the non-diabetic population; and c) determine whether iodine levels are related to several clinical and laboratory parameters characteristic of diabetic syndrome, including thyroid status. Subjects and methods: A total of 54 males and 51 females treated for type 1 diabetes mellitus (DM1) were included in this cross-sectional study. In addition to iodine saturation determined as the concentration of iodine in the first urine sample of the day, we measured clinical, anthropometric, and biochemical parameters in relation to DM1. Results: Measured iodine levels were: median 152 μg/l, first quartile 117 μg/l, and third quartile 219 μg/l. More than 50% of iodine levels varied within the optimal saturation range of 100–200 μg/l, while about 14% showed incomplete saturation (<100 μg/l), and 34% had increased saturation (>200 μg/l). Multi-dimensional regression showed significant positive relationships; (an OPLS model explaining 9% of the variability) between ioduria and male sex, body weight and height, and serum creatinine levels, which to date have not yet been published. Relationships to the other analyzed parameters (glycated hemoglobin, insulin dose, DM duration, body mass index, microalbuminuria, glomerular filtration rate, thyroid function and volume, thyroid autoimmune markers) were not significant. Conclusions: Iodine saturation levels in our study group were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non-diabetic population, and patients with diabetic syndrome did not differ with respect to the chosen normal ioduria concentrations, i.e. 100 or 150 μg/l. The question remains, however, whether past attempts to deal with iodine deficits in the Czech Republic are responsible for this satisfactory iodine status of the type 1 diabetic population, or if there are other factors involved.
- MeSH
- albuminurie diagnostické zobrazování MeSH
- autoprotilátky krev MeSH
- diabetes mellitus 1. typu * patofyziologie MeSH
- dospělí MeSH
- hodnoty glomerulární filtrace MeSH
- jod metabolismus moč nedostatek MeSH
- jodidperoxidasa imunologie krev MeSH
- kreatinin krev MeSH
- lidé MeSH
- thyreotropin krev MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
Úvod: O stavu zásobení jodem a důsledcích ev. jodového deficitu jsou u nemocných s diabetem obou typů k dispozici překvapivě jen sporadická data. Hlavním cílem naší studie bylo získat základní informace (a) o stavu saturace jodem u diabetiků 1. typu, (b) do jaké míry se odlišuje od nediabetické populace, (c) zda zásobení jodem souvisí s některými klinickými a laboratorními charakteristikami diabetického syndromu, včetně stavu štítné žlázy. Soubor a metody: Bylo vyšetřeno 54 mužů a 51 žen léčených pro diabetes mellitus 1. typu (DM1T). Studie má průřezový charakter. Saturaci jodem jsme posuzovali podle koncentrace jodu ve vzorku první ranní moči. Výsledky: Jodurie v celém souboru: medián 152 μg/l, 25. kvartil 117 μg/l, 75. kvartil 219 μg/l. Více než 50 % vyšetřených jodurií se pohybovalo v pásmu optimální saturace (100–200 μg/l), 13 % v pásmu nedostatečné saturace (< 100 μg/l), v pásmu zvýšené saturace (> 200 μg/l) bylo 35 % pacientů. Využitím vícerozměrné regrese dat jsme prokázali významnou pozitivní závislost mezi jodurií a mužským pohlavím, hmotností, výškou a kreatininem v séru. K hodnotě HbA1c, dávce inzulinu, trvání diabetes mellitus, BMI, mikroalbuminurii, eGF a ukazatelům funkce a volumu štítné žlázy včetně markerů tyreoidální autoimunity se významné korelace neprokázaly. Závěrem lze konstatovat: Saturace jodem u námi vyšetřovaných nemocných s DM1T odpovídala ICCIDD (WHO) požadavkům na optimální/dobrou saturaci u nediabetické populace. S ohledem na zvolenou normální koncentraci jodurie, to je 100, resp. 150 μg/l se obraz diabetického syndromu nelišil. Otázka, zda se na dobrém stavu zásobení populace pacientů s DM1T jodem podílejí ještě jiné faktory než opatření podniknutá v minulosti pro řešení jodového deficitu v České republice, by měla být předmětem dalšího výzkumu na větších souborech nemocných.
Introduction: In patients with type 1 and 2 diabetes mellitus only rare data concerning the status of iodine supplementation and impact of possible iodine deficiency is available. Aim: To get basic information about (a) state of supply with iodine in patients with type 1 diabetes mellitus (DM1T), (b) the difference from non-diabetic population, (c) possible association of iodine saturation with some clinical and laboratory features of the diabetic syndrome, including the state of thyroid gland. Subjects and methods: We examined 54 men and 51 women treated with DM1T in a cross-sectional study. Age: median 42 years (25th quartil 31, 75th quartil 55), DM1T duration: 18 years (13, 23), BMI: 25.9 (23.3, 29.7), HbA1c: 61 mmol/mol (51, 71), creatinine: 71 μmol/l (61, 83), micro-albuminuria 4.3 μg/min (1.9, 11.8), TSH: 1.77 mIU/l (1.12, 2.80). The iodine saturation was evaluated using iodine concentration in a sample of first morning urine. Results: Urinary iodine concentration in the whole group: median 152 μg/l, 25th quartile 117 μg/l, 75th quartile 219 μg/l. More than 50 % of the urinary iodine samples fell within range of optimal saturation (100–200 μg/l), 13 % within insufficient saturation (< 100 μg/l), 35 % of the samples showed increased saturation (> 200 μg/l), in which 2/3 were men. Using multiple regression analysis we found significant positive association of urinary iodine concentration and male gender, body weight, stature, and serum creatinine. No relation between urinary iodine and clinical and laboratory features of the diabetic syndrome was found. Conclusions: Iodine saturation in examined patients with DM1T was in accordance with ICCIDD (WHO) requirements for optimal/good saturation in non-diabetic population. With respect to the chosen normal urinary iodine concentration, eg. 100, resp. 150 μg/l the features of diabetic syndrome were not different. The question whether other factors than general measures taken in the past for solution of the iodine deficiency in the Czech Republic are involved in good level of iodine saturation in patients with DM1T should be addressed in further investigations comprising larger cohorts of patients.
- MeSH
- albuminurie moč MeSH
- diabetes mellitus 1. typu * komplikace krev moč MeSH
- dospělí MeSH
- glykovaný hemoglobin metabolismus MeSH
- hodnoty glomerulární filtrace MeSH
- hormony štítné žlázy krev MeSH
- index tělesné hmotnosti MeSH
- jod * moč nedostatek MeSH
- kreatinin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- průřezové studie MeSH
- regresní analýza MeSH
- štítná žláza ultrasonografie MeSH
- vitamin D krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
Prevalence of the metabolic syndrome is around 25% in Europe but its occurrence grows in both genders with increasing age and weight. Lifestyle factors may contribute to the risk of developing metabolic syndrome. The objective of this study was to determine the relationship between metabolic syndrome and eating habits as well as length of sleep and smoking. Participants (519 women and 286 men aged 18–65 years) were chosen by random selection and questioned about their eating habits, sleep length and smoking. This information was combined with anthropometric and clinical parameters of metabolic syndrome. The female group was divided into two subgroups depending on climacteric stage (before and after menopause). Metabolic syndrome prevalence does not differ between regions in neither female (29.9%) nor male (32.5%) group. Body mass index ≥25 was detected in 50.4% of all women and 65.7% of men; 23.5% of all women and 21.7% men had body mass index ≥30. In conclusion, metabolic syndrome prevalence was proved to depend on eating habits and family heredity. Positive correlation between the above mentioned factors demonstrated itself in the total sample but not in individual regions. Metabolic syndrome prevalence in Czech adults is comparable with neighbouring countries. No significant interregional differences in metabolic syndrome prevalence within the Czech Republic were detected. In conclusion, relationship between eating habits and metabolic syndrome was confirmed.
- MeSH
- dieta MeSH
- dospělí MeSH
- kouření epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- metabolický syndrom epidemiologie etiologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- obezita epidemiologie etiologie MeSH
- prevalence MeSH
- přijímání potravy MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
