• Publikační typ
• abstrakt z konference MeSH

Countering the trend in specialization, we advocate the transdisciplinary monitoring of blood pressure and heart rate for signatures of environmental cyclic and other variabilities in space as well as terrestrial weather on the one hand, and for surveillance of personal and societal health on the other hand. New rules (if confirmed novel laws) emerge as we recognize our inheritance from the cosmos of cycles that constitute and characterize life and align them with inheritance from parents. In so doing, we happen to follow the endeavors of Gregor Mendel, who recognized the segregation and independent assortment of what became known as genes. Circadians, rhythms with periods, ?, between 20 and 28 hours, and cycles with frequencies that are higher (ultradian) or lower (infradian) than circadian, are genetically anchored. An accumulating long list of very important but aeolian (nonstationary) infradian cycles, characterizing the incidence patterns of sudden cardiac death, suicide and terrorism, with drastically different ?s, constitutes the nonphotic (corpuscular emission from the sun, heliogeomagnetics, ultraviolet flux, gravitation) Cornélissen-series .

• MeSH
• ambulantní monitorování krevního tlaku MeSH
• biologické hodiny fyziologie   MeSH
• chronobiologické jevy fyziologie   MeSH
• cirkadiánní rytmus MeSH
• elektromagnetické jevy MeSH
• financování organizované MeSH
• kardiovaskulární fyziologické jevy MeSH
• krevní tlak fyziologie   MeSH
• lidé MeSH
• periodicita MeSH
• sluneční aktivita MeSH
• srdeční frekvence fyziologie   MeSH
• Země (planeta) MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

Three spectral components with periods of about (~) 0.41, ~0.5 and ~1.0 year had been found with serially independent sampling in human circulating melatonin. The time series consisted of around-the-clock samples collected for 24 hours at 4-hour intervals from different patients over several years. Some of these components had been found to be circadian stage-dependent, the daytime measurements following mostly a circannual variation, whereas a half-year characterized the nighttime samples. The latter were incorporated into a circasemiannual map. The relative brevity of the series prevented a check for the coexistence of all three spectral components, even if each component seemed to have a raison d'etre. In time series of transdisciplinary data, a 1.00-year synchronized component is interpreted as representing the seasons. The half-year may qualify the circannual waveform, but it is also a signature of geomagnetics. An ~0.41-year (~5-month) component is the signature of solar flares. It has been called a cis-half-year (cis = on this side of a half-year) and may be detected only intermittently. Charles L. Wolff predicted the existence, among others, of ~0.42- and ~0.56-year components as beat periods of rotations at different solar latitudes.The multiple components characterizing circulating melatonin could also be found in a (to our knowledge unique) data set of a clinically healthy scientist (RBS). Herein, we focus on vascular data self-measured by RBS as he aged from ~20 to ~60 years. A multi-component model consisting of cosine curves with periods of 0.41, 0.50 and 1.00 year was fitted to weekly means of systolic (S) and diastolic (D) blood pressure (BP) and heart rate (HR) collected ~5 times a day over 39 years by RBS. All three components can coexist for a while, although all of them are nonstationary in their characteristics and come and go by the criterion of statistical significance.Intermittently, BP and HR are synchronized selectively with one or the other aspect of RBS' physical environment, namely the seasons (at ~1.0 year), earth magnetism (at ~0.5 year) and/or solar flares (at ~0.42 year). Cosmic-biotic transfer of information, albeit hardly of energy (the biospheric amplitudes are very small) may be mediated in this set of frequency windows. As found earlier, RBS' circulation is also frequency-trapped environmentally in multidecadal windows, HR being locked into the transtridecadal Brückner, or rather Brückner-Egeson-Lockyer, BEL sunspot and terrestrial weather cycle, while his BP follows Hale's didecadal cycle in the changing polarity of sunspots.The ~0.41-year HR cycle may be associated with changes in solar flares, the cis-half-year amplitude of HR showing a cross-correlation coefficient of 0.79 with the total solar flare index (from both solar hemispheres) at a lag of ~3.2 years. The superposed time courses of these two variables indicate the presence of a shared Horrebow-Arago-Schwabe sunspot cycle of ~11 years, the cis-half-year in HR being more prominent after the total solar flare index reaches its ~11-year peak. Differences in the time-varying behavior of BP vs. HR are also described.

• MeSH
• ambulantní monitorování krevního tlaku MeSH
• časové faktory MeSH
• chronobiologické jevy fyziologie   MeSH
• cirkadiánní rytmus fyziologie   MeSH
• financování organizované MeSH
• krevní tlak fyziologie   MeSH
• lidé MeSH
• magnetismus MeSH
• melatonin fyziologie   krev   MeSH
• roční období MeSH
• sluneční aktivita MeSH
• srdeční frekvence fyziologie   MeSH
• Země (planeta) MeSH
• Check Tag
• lidé MeSH

• MeSH
• arteriae carotides fyziologie   MeSH
• baroreflex fyziologie   MeSH
• chronobiologické jevy fyziologie   MeSH
• cirkadiánní rytmus fyziologie   MeSH
• dospělí MeSH
• financování organizované MeSH
• hypertenze etiologie   patofyziologie   MeSH
• konstrikce MeSH
• krevní tlak fyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie metody   přístrojové vybavení   statistika a číselné údaje   MeSH
• měření krevního tlaku metody   MeSH
• rychlost toku krve fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• stehno krevní zásobení   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH

• MeSH
• ambulantní monitorování krevního tlaku metody   přístrojové vybavení   statistika a číselné údaje   MeSH
• časové faktory MeSH
• chronobiologické jevy fyziologie   MeSH
• cirkadiánní rytmus fyziologie   MeSH
• financování organizované MeSH
• ischemická choroba srdeční patofyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• monitorování fyziologických funkcí MeSH
• senioři MeSH
• studie případů a kontrol MeSH
• věkové faktory MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH

• Klíčová slova
• hodnoty denního a nočního krevního tlaku během týdenního monitorování,
• MeSH
• ambulantní monitorování krevního tlaku * metody   využití   MeSH
• dospělí MeSH
• experimenty na lidech MeSH
• hodnotící studie jako téma MeSH
• lidé středního věku MeSH
• lidé MeSH
• měření krevního tlaku metody   přístrojové vybavení   využití   MeSH
• periodicita * MeSH
• senioři MeSH
• statistika jako téma MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

• Klíčová slova
• hodnoty denního a nočního krevního tlaku během týdenního monitorování, edukace selfmonitoringu krevního tlaku,
• MeSH
• ambulantní monitorování krevního tlaku * metody   přístrojové vybavení   využití   MeSH
• dospělí MeSH
• experimenty na lidech MeSH
• hodnotící studie jako téma MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• periodicita * MeSH
• senioři MeSH
• statistika jako téma MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

Molecular clocks present in organs and individual cells throughout the body are central for the temporal coordination of rhythms in internal biological processes among themselves and with external environmental cycles; altered function of specific clock gene (CG) components can have significant impact relevant to health and disease. We herein review current knowledge pertaining to the presence and robustness of circadian rhythms in CGs in the suprachiasmatic nucleus and peripheral organs, and the importance of CGs to general health and the diagnosis and treatment of human disorders and disease. Also discussed are developmental aspects of rhythms in some CGs and tissues, time of day vs. circadian stage, using synchronized vs. constant conditions to monitor a rhythm, and subjective vs. objective interpretations of rhythms. To emphasize the latter, chronobiological statistics (ANOVA, single cosinor) are applied to published circadian CG mRNA expression data (which had been described subjectively) as an example of objectively determining rhythm probability and obtaining estimates for circadian amplitudes and acrophases. The data base consisted of 14 CGs (mPer1,2,3, mCry1,2, mBmal1, mCK1?,?, mClock, mDbp, mNpas2, mRev-erb?,ß, mTim) in each of 7 mouse organs harvested every 4h for 24h from male Balb/c mice on day 3 in continuous darkness. Excluding the usually non–24h-rhythmic testis and CG mTim, rhythms significant at p?0.05 were found in 81% (63/78) of CGs and when including borderline significant at p?0.10, in 97% (76/78) of CGs. A statisticallydetermined circadian amplitude and acrophase for each CG in each tissue can be useful in making objective comparisons of rhythm parameters in CGs between various peripheral organs, species, and/or studies of different conditions (e.g., photoperiods, feeding schedules, aging, disease). Use of these parameters adds new endpoints for diagnoses and approaches for therapeutic interventions in conditions where disturbance of circadian CG expression is an important cause of morbidity associated with chronic illnesses and diseases with a strong circadian component, including cardiovascular disease, epilepsy, cancer, metabolic syndrome, and sleep-related disorders, among others, also reviewed herein.

• MeSH
• biologické hodiny fyziologie   genetika   MeSH
• chronická nemoc MeSH
• chronobiologické poruchy genetika   MeSH
• cykly aktivity fyziologie   genetika   MeSH
• flavoproteiny farmakokinetika   MeSH
• modely u zvířat MeSH
• myši MeSH
• proteiny buněčného cyklu genetika   MeSH
• transportní proteiny genetika   MeSH
• Check Tag
• myši MeSH
• Publikační typ
• grafy a diagramy MeSH
• tabulky MeSH

We analyzed cycles with periods, tau, in the range of 0.8-2.0 years, characterizing, mostly during 1999-2003, the incidence of sudden cardiac death (SCD), according to the International Classification of Diseases, 10th revision (ICD10), code I46.1. In the tau range examined, only yearly components could be documented in time series from North Carolina, USA; Tbilisi, Georgia; and Hong Kong, in the latter two locations based on relatively short time series. By contrast, in Minnesota, USA, we found only a component with a longer than (= trans) yearly (transyearly) tau of 1.39 years; the 95% confidence interval (CI) of the tau extended from 1.17 to 1.61 years, falling into the category of transyears (defined as a tau and a 95% CI between 1.0 and 2.0 years, with the limits of the 95% CI of the spectral component's tau overlapping neither of these lengths). During the same span from 1999 to 2003 in Arkansas, USA, a component of about 1-year in length was present, and in addition, one with a tau of 1.69 year with a CI extending from 1.29 to 2.07 years, a far-transyear candidate, far-transyears being defined as having a tau with a CI between 1.20 and 2.0 year, with the CI overlapping neither of these lengths. In the Czech Republic, there was also a calendar-yearly tau and one of 1.76 years. In the latter two geographic/geomagnetic areas, the about-yearly and the longer cycles' amplitudes were of similar prominence. The taus are only candidate transyears; the 95% CIs of their taus overlap the 2-year length. When a series on SCD from 1994 to 2003 from the Czech Republic was analyzed, the 95% CI of the transyear's tau no longer overlapped the 2-year length. Transyears were also found in the Czech Republic for myocardial infarctions (MI), meeting the original transyear definition in both a shorter and a longer series. Moreover, in the 1994-2003 series on MI from the Czech Republic, a near-transyear was also found, meeting the definition of a period with a 95% CI overlapping neither precisely 1.0 year nor 1.2 years, along with a far-transyear, defined as a tau between 1.2 and 2.0 years, again with the 95% CI covering neither of these lengths. Herein, we discuss near- and far-transyears more generally in the light of their background in physics and the concept of reciprocal cyclicities.

• MeSH
• chronobiologické jevy * MeSH
• infarkt myokardu epidemiologie   MeSH
• lidé MeSH
• náhlá srdeční smrt epidemiologie   MeSH
• sluneční aktivita * MeSH
• zeměpis MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH
• přednášky MeSH
• Research Support, N.I.H., Extramural MeSH
• Geografické názvy
• Česká republika MeSH
• Gruzie epidemiologie   MeSH
• Hongkong epidemiologie   MeSH
• Spojené státy americké epidemiologie   MeSH

The predictive value of blood pressure (BP), heart rate (HR), and catecholamines in terms of any subsequent development of cardiovascular disease was investigated. Systolic (S) and diastolic (D) BP, HR, epinephrine (E) and norepinephrine (NE) were measured three times a year in 1980, 1984, and 1989 on 20 clinically healthy subjects, 18 patients with 'essential hypertension', and 22 patients with angina pectoris. Of the 22 patients in the latter group, 15 died during a 2-year follow-up (1990-1991). Each individual data series was analyzed by single cosinor to assess the circannual variation. Results were summarized by population-mean cosinor for each group. Parameter tests were used to compare the circannual rhythm characteristics among the different patient groups. A circannual rhythm was invariably demonstrated on a group basis (P < 0.05). Differences in MESOR and/or circannual amplitude were found among the different groups. In particular, patients with angina pectoris who will die within the 2-year follow-up differ in terms of their E and NE from all other patient groups, a difference already detected at the beginning of the study, more than 10 years before they die. A similar separation is not achieved in terms of BP or HR.

• MeSH
• adrenalin krev   MeSH
• financování organizované MeSH
• hypertenze patofyziologie   MeSH
• kardiovaskulární nemoci krev   mortalita   patofyziologie   MeSH
• katecholaminy krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• následné studie MeSH
• noradrenalin krev   MeSH
• prediktivní hodnota testů MeSH
• roční období MeSH
• shluková analýza MeSH
• srdeční frekvence fyziologie   MeSH
• ukazatele zdravotního stavu MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH