Manažment dyslipidémií ostáva výzvou napriek objemu kvalitných dát a dostupnosti liečebných modalít. Epidémia aterosklerotického kardiovaskulárneho ochorenia je dominantnou príčinou chorobnosti a úmrtnosti vo vyspelom svete. Prienik Odporúčaní pre manažment dyslipidémií do ostatných dokumentov dokazuje význam tejto problematiky. Nové poznatky vedú k sprísneniu cieľových hodnôt pre LDL-cholesterol podľa stupňa kardiovaskulárneho rizika. Ročná mortalita po akútnom koronárnom syndróme v porovnaní s vyspelejšími krajinami neúmerne rastie. Analýza príčin poukazuje na zlý manažment rizikových faktorov po prepustení z hospitalizácie. Možnosti zlepšenia okrem iného smerujú k zmene indikačných obmedzení pre PCSK9-inhibítory.
The management of dyslipidemia remains a challenge despite the volume of EBM data and the availability of treatment modalities. The ASCVD epidemic is the dominant cause of morbidity and mortality in the developed world. The integration of the Guidelines for the Management of Dyslipidemias into other documents demonstrates the importance of this issue. New findings lead to the tightening of LDL-C target values according to CV risk levels. Annual mortality after ACS in Slovakia is rising disproportionately compared to more developed countries. The root cause analysis points to poor management of risk factors after hospital discharge. Opportunities for improvement include, inter alia, the changing of the indication restrictions for PCSK9 inhibitors.
- MeSH
- akutní koronární syndrom * patologie MeSH
- dyslipidemie * farmakoterapie MeSH
- LDL-cholesterol krev škodlivé účinky MeSH
- lidé MeSH
- management nemoci MeSH
- rizikové faktory kardiovaskulárních chorob MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Slovenská republika MeSH
The resolving power of multicomponent spectral analysis and the computation reliability of the stability constants and molar absorptivities determined for five variously protonated anions of physostigmine salicylate by the SQUAD(84) and SPECFIT/32 programs has been examined with the use of simulated and experimental spectra containing overlapping spectral bands. The reliability of the dissociation constants of drug was proven with goodness-of-fit tests and by examining the influence of pre-selected noise level s(inst)(A) in synthetic spectra regarding the precision s(pK) and also accuracy of the estimated dissociation constants. Precision was examined as the linear regression model s(pK)=β(0)+β(1)s(inst)(A). In all cases the intercept β(0) was statistically insignificant. When an instrumental error s(inst)(A) is small and less than 0.5 mAU, the parameters' estimates are nearly the same as the bias ΔpK=pK(a,calc)-pK(a,true) is quite negligible. In all four dissociation constants the bias seems to be quite small even though for pK(a4) it is a little bit higher, i.e., +0.05 for s(inst)(A) about 1.0 mAU. In the interval of s(inst)(A) from 0.1 to 1.0 mAU all four dissociation constants pK(i) are accurate enough. Of the various regression diagnostics considered, the goodness-of-fit is the most efficient criterion of whether the parameters found adequately represent the data. The magnitude of instrumental error s(inst)(A) only slightly affects the shape of a Cattel's scree graph s(k)(A)=f(k) to determine the true number of light-absorbing species in the equilibrium mixture.
- MeSH
- absorpce MeSH
- chemické modely MeSH
- fysostigmin analýza chemie MeSH
- kinetika MeSH
- koncentrace vodíkových iontů MeSH
- počítačová simulace MeSH
- povrchové vlastnosti MeSH
- protony MeSH
- regresní analýza MeSH
- reprodukovatelnost výsledků MeSH
- software MeSH
- spektrofotometrie metody MeSH
- termodynamika MeSH
- titrace metody MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
