OBJECTIVE: To date, very few studies have focused on structural changes and their association with cognitive performance in isolated REM sleep behaviour disorder (iRBD). Moreover, the results of these studies are inconclusive. This study aims to evaluate differences in the associations between brain morphology and cognitive tests in iRBD and healthy controls. METHODS: Sixty-three patients with iRBD and thirty-six controls underwent MRI with a 3 T scanner. The cognitive performance was assessed by a comprehensive neuropsychological battery. Based on performance, the iRBD group was divided into two subgroups with (iRBD-MCI) and without mild cognitive impairment (iRBD-NC). The high-resolution T1-weighted images were analysed using an automated atlas segmentation tool, voxel-based (VBM) and deformation-based (DBM) morphometry to identify between-group differences and correlations with cognitive performance. RESULTS: VBM, DBM and the comparison of ROI volumes yielded no significant differences between iRBD and controls. In the iRBD group, significant correlations in VBM were found between several cortical and subcortical structures primarily located in the temporal, parietal, occipital lobe, cerebellum, and basal ganglia and three cognitive tests assessing psychomotor speed and one memory test. Between-group analysis of cognition revealed a significant difference between iRBD-MCI and iRBD-NC in tests including a processing speed component. CONCLUSIONS: iRBD shows deficits in several cognitive tests that correlate with morphological changes, the most prominent of which is in psychomotor speed and visual attention as measured by the TMT-A and associated with the volume of striatum, insula, cerebellum, temporal lobe, pallidum and amygdala.
In Parkinson's disease (PD), impaired gait and cognition affect daily activities, particularly in the more advanced stages of the disease. This study investigated the relationship between gait parameters, cognitive performance, and brain morphology in patients with early untreated PD. 64 drug-naive PD patients and 47 healthy controls (HC) participated in the study. Single- and dual-task gait (counting task) were examined using an expanded Timed Up & Go Test measured on a GaitRite walkway. Measurements included gait speed, stride length, and cadence. A brain morphometry analysis was performed on T1-weighted magnetic resonance (MR) images. In PD patients compared to HC, gait analysis revealed reduced speed (p < 0.001) and stride length (p < 0.001) in single-task gait, as well as greater dual-task cost (DTC) for speed (p = 0.007), stride length (p = 0.014) and cadence (p = 0.029). Based on the DTC measures in HC, PD patients were further divided into two subgroups with normal DTC (PD-nDTC) and abnormally increased DTC (PD-iDTC). For PD-nDTC, voxel-based morphometric correlation analysis revealed a positive correlation between a cluster in the left primary motor cortex and stride-length DTC (r = 0.57, p = 0.027). For PD-iDTC, a negative correlation was found between a cluster in the right lingual gyrus and the DTC for gait cadence (r=-0.35, pFWE = 0.018). No significant correlations were found in HC. The associations found between brain morphometry and gait performance with a concurrent cognitive task may represent the substrate for gait and cognitive impairment occurring since the early stages of PD.
- MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie * MeSH
- mozek * diagnostické zobrazování patologie patofyziologie MeSH
- neurologické poruchy chůze * etiologie patofyziologie diagnostické zobrazování patologie MeSH
- neuropsychologické testy MeSH
- Parkinsonova nemoc * diagnostické zobrazování patofyziologie patologie komplikace MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Kognitivní porucha je u velké části případů součástí onemocnění schizofrenního okruhu a ovlivňuje závažnou měrou psychosociální fungování nemocných. Celosvětově se k její diagnostice aktuálně nejčastěji používá baterie kognitivních testů MATRICS (NIMH-MATRICS: Measurement and Treatment Research to Improve Cognition in Schizophrenia; MATRICS Consensus Cognitive Battery; MCCB). Adaptace baterie MCCB do českého prostředí proběhla v r. 2015, v r. 2020 proběhla validační studie klasifikační přesnosti na pacientech se schizofrenií, v r. 2021 byla završena normativní studií. Ve stejném roce byl rovněž dokončen oficiální český převod pod vedením (www. matricsinc.org), který lze používat například v psychofarmakologických studiích. Pro určení, zda jsou normativní data experimentální verze srovnatelná a použitelná i pro verzi oficiální, údaje zatím chybějí. Cílem naší studie tedy bylo dokončit dosavadní výzkum srovnávací studií ekvivalence experimentálního převodu z r. 2015 s oficiálním z r. 2021. Pro tento cíl jsme nabrali nový soubor pacientů trpících schizofrenií (SCH, n = 15) a porovnali s daty dvou kontrolních souborů z předchozích studií: s kontrolním souborem zdravých jedinců převzatých z normativní studie (CON-H, n = 53) a s pacienty se schizofrenií z validační studie (CON-SCH, n = 38). Soubory byly párovány dle věku, vzdělání a pohlaví pomocí statistického softwaru R. Klíčovým zjištěním bylo, že skupiny SCH a CON-SCH neměly statisticky významné rozdíly v žádném z testů MCCB. Skupina CON-SCH dosáhla ve všech testech statisticky nižšího skóre než skupina CON-H. Skupina SCH rovněž dosáhla nižšího skóre než skupina CON-H s výjimkou testu prostorový rozsah z WMS-III, nicméně i v tomto testu byl nalezen trend k významnosti. Těmito výsledky jsme podpořili následující zjištění: experimentální a oficiální český převod MCCB se jeví jako ekvivalentní; normativní data MCCB jsou použitelná i pro verzi oficiální; MCCB je nástroj, který významně rozlišuje zdravé osoby a soubory pacientů se schizofrenií dle kognitivního výkonu. Souhrnně můžeme doporučit oficiální českou adaptaci baterie MCCB jako efektivní nástroj pro vyšetření kognitivní poruchy u schizofrenie v českých psychiatrických zařízeních.
Cognitive impairment is one of the symptoms of schizophrenia spectrum disorders present in in the majority of cases and has a significant impact on the psychosocial functioning of patients. The MATRICS cognitive test battery (NIMH-MATRICS: Measurement and Treatment Research to Improve Cognition in Schizophrenia; MAT-RICS Consensus Cognitive Battery; MCCB) is currently the most often used cognitive test battery for assessing the cognitive functions of patients with schizophrenia worldwide. The adaptation of the MCCB battery to the Czech environment was realized in 2015, a validation study of classification accuracy on schizophrenia patients was conducted in 2020 and a normative study was completed in 2021. In the same year, an official Czech translation (www.matric-sinc.org) was also completed. This version can be used for example in psychopharmacological studies. There was not enough information available to determine whether the normative data of the experimental version are comparable and applicable to the official version. Thus, our study aimed to complete the preceding research and to determine the equivalence of both versions by comparing the experimental translation from 2015 with the official translation from 2021. For this purpose, we recruited a new cohort of patients with schizophrenia (SCH, n = 15) and compared it with data from two control cohorts from previous studies: a cohort of healthy control subjects was taken from the normative study (CON-H, n = 53) and patients with schizophrenia from the validation study (CON-SCH, n = 38). The groups were matched by age, education, and sex using the statistical software R. A key finding was that the SCH and CON-SCH groups did not show statistically significant differences in any of the MCCB tests. The CON-SCH group scored statistically lower than the CON-H group in all tests. The SCH group also scored statistically lower in all tests except the spatial span test from the WMS-III; however, a trend toward statistical significance was found in this test as well. These results support the following findings: the experimental and the official Czech version of the MCCB appear to be equivalent; the normative data of the MCCB are also applicable within the scope of use of the official version; the MCCB is an instrument that significantly discriminates between healthy subjects and populations of patients with schizophrenia according to cognitive performance. Overall, we can recommend the official Czech adaptation of the MCCB battery as an effective tool for assessing the cognitive functions of patients with schizophrenia in Czech psychiatric hospitals.
OBJECTIVE: The present study aims to examine whether declarative memory dysfunction relates to impaired core memory mechanisms or attentional and executive dysfunction in idiopathic REM Sleep Behavior Disorder (iRBD). METHOD: In this observational, cross-sectional study, were enrolled 82 individuals with the diagnosis of iRBD according to the International Classification of Sleep Disorders and 49-matched healthy controls fulfilling inclusion criteria. All participants underwent two memory tasks, namely the Rey Auditory Verbal Learning Test (RAVLT) and Memory Binding Test (MBT), which include conditions of varying degrees of dependence on executive functioning, as well as different indicators of core memory processes (e.g., learning, retention, relational binding). RESULTS: We used Bayesian multivariate generalized linear model analysis to evaluate the effect of iRBD on memory performance controlled for effects of age and sex. Individuals with iRBD displayed worse memory performance in the delayed free recall task (b = -0.37, 95% PPI [-0.69, -0.05]), but not on delayed recognition of the same material. Their performance in cued recall tasks both in immediate and delayed conditions was in comparison to controls relatively spared. Moreover, the deficit in delayed free recall was mediated by attention/processing speed. CONCLUSIONS: In iRBD, we replicated findings of reduced free recall based on inefficient retrieval (retrieval deficit), which was small in terms of effect size. Importantly, the memory profile across measures does not support the presence of core memory dysfunction, such as poor learning, retention or associative binding.
Background: Everyday functioning and instrumental activities of daily living (IADL) play a vital role in preserving the quality of life in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). Objective: The main goal of the current study was to examine IADL change in pre-and post-surgery of the STN-DBS. We also analyzed the influence of the levodopa equivalent daily dose (LEDD) and global cognitive performance (Dementia Rating Scale; DRS-2) as covariates in relation to IADL. Methods: Thirty-two non-demented PD patients were administered before and after STN-DBS neurosurgery the Penn Parkinson's Daily Activities Questionnaire (PDAQ; self-report), the DRS-2 and Beck Depression Inventory (BDI-II) to assess IADL change, global cognition, and depression. Results: We found a positive effect of STN-DBS on IADL in the post-surgery phase. Moreover, lower global cognition and lower LEDD are predictive of lower IADL in both pre-surgery and post-surgery examinations. Summary/Conclusion: STN-DBS in PD is a safe method for improvement of everyday functioning and IADL. In the post-surgery phase, we show a relation of IADL to the severity of cognitive impairment in PD and to LEDD.
- Publikační typ
- časopisecké články MeSH
Cíl: Pilotní studie české verze Mini-Cog poskytuje základní statistické údaje k testu a diagnostickému usuzování u neurodegenerativních onemocnění. Úvod: Prevalence syndromu demence jako neurobehaviorálního korelátu neurodegenerativních onemocnění mozku se dle epidemiologických propočtů v ČR do r. 2050 významně zvýší. Mini-Cog, rychlá screeningová zkouška syndromu demence, má dle doporučení Společnosti všeobecného lékařství České lékařské společnosti J. E. Purkyně (SVL ČLS JEP) za účel sloužit v primární praxi praktického lékaře u netříděné populace osob vyššího věku. Metodika: Zdraví účastníci, kteří splnili vylučovací kritéria pro zařazení (N = 46), průměrný věk 59,7 (SD = 8,9) let, prošli psychologickým vyšetřením pomocí Mini-Cog a Mini-Mental State Examination (MMSE) ve střídavém pořadí. Výsledky: Průměrný výkon v Mini-Cog (0–5) byl 4,3 (1,0) a v MMSE (0–30) byl 29,4 (0,9). Dle percentilového převodu výkonu v Mini-Cog se hrubé skóre 2/5 v české populaci rovná 2. percentilu (významný podprůměr). Dle ekvipercentilového srovnání k MMSE jsou 2/5 body rovny 26 až 27 bodům v MMSE (indikuje shodně hraniční skór pro mírnou kognitivní poruchu). Výsledek 3, 4 a 5 bodů v Mini-Cog je roven průměru. Závěr: Předložená data k Mini-Cog v české verzi umožňují empiricky podložené diagnostické usuzování ohledně kognitivního výkonu u osob v riziku rozvoje neurodegenerativních onemocnění v primární péči praktického lékaře.
Objective: We performed a pilot study of the Mini-Cog Czech version to obtain statistical information for empirically derived diagnostic decision-making in patients with possible neurodegenerative diseases. Introduction: Between 2022 and 2050, the prevalence of dementia in the Czech Republic as a neurobehavioral correlate of neurodegeneration will dramatically increase as based on epidemiological data. According to Czech Society of General Practice in Czech Medical Association of J. E. Purkyně (SVL ČLS JEP) guidelines, The Mini-Cog, a rapid screening test for dementia, is the recommended cognitive scale for general practitioners in primary clinical care for screening patients of higher age. Methods: Healthy participants who fulfilled the inclusion criteria (N = 46), mean age 59,7 (SD = 8,9), underwent a brief cognitive screening with the Mini-Cog and the Mini-Mental State Examination (MMSE) in counterbalanced order. Results: Mean Mini-Cog performance (range 0–5) was 4,3 ± 1,0 points and in the MMSE (range 0–30) was 29,4 ± 0,9 points. After transformation of the Mini-Cog raw score to percentiles, a raw score of 2/5 is equal to the 2nd percentile (significantly below average). Based on the equi-percentile transformation a raw score of 2/5 in the Mini-Cog is equal to 26 or 27 points in the MMSE, which is a traditional cut-off for mild cognitive impairment. Mini-Cog raw scores from 3 to 5 are within average. Conclusion: The data from the current study enable general practitioners to make empirically derived diagnostic decision-making in patients with possible neurodegenerative diseases in primary clinical care.
- MeSH
- demence * diagnóza epidemiologie MeSH
- klinická studie jako téma MeSH
- kognitivní poruchy diagnóza MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- plošný screening MeSH
- primární zdravotní péče MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- práce podpořená grantem MeSH
OBJECTIVE: The MATRICS consensus cognitive battery (MCCB) is a widely used neuropsychological battery for the assessment of cognitive dysfunction in schizophrenia. However, the accuracy of measurement is dependent on suitable normative data which are in the Czech Republic lacking. METHOD: The Czech academic research translation of the MCCB battery was administered to a sample of healthy volunteers aged 17 to 62 years (N = 573) and the effects of age, education and sex were examined. In addition, a comparison was made to examine the differences between the US and current normative data. RESULTS: Consistent with previous studies, significant effects of age, sex and education were found, however, in sex and education in distinct MCCB-domains. By comparing the original and current normative data, significant differences with small to large effect sizes were revealed in all domains except for Verbal Learning. CONCLUSIONS: We present nationally specific MCCB regression-based and tabular normative data applicable in research and clinical settings.
- MeSH
- kognice * MeSH
- konsensus MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- schizofrenie (psychologie) * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
Neuropsychologie v České republice se postupně stále více stává kompetitivním oborem i na mezinárodní úrovni. Dostupnost standardizovaných neuropsychologických testových metod je však oproti zahraničí výrazně omezená. To limituje jak další rozvoj oboru, tak poskytování péče v rámci tzv. přístupu založeného na důkazech. Jednou z chybějících metod v české praxi je i Krátký test zrakově-prostorové paměti – revize (BVMT-R). Zpráva stručně představuje tuto testovou metodu.
Neuropsychology in the Czech Republic is increasingly becoming a competitive field at the international level. However, the availability of standardized neuropsychological test methods is significantly limited compared to abroad. This limits both the further development of the field and the provision of evidence-based health care. One of the lacking methods in Czech practice is the Brief Visuospatial Memory Test-Revised (BVMT-R). The report briefly introduces this neuropsychological test.
Introduction: The Brief Visual Memory Test-Revised (BVMT-R) is a frequently used visuospatial declarative memory test, but normative data in the Czech population are lacking. Moreover, the BVMT-R includes promising learning indexes that can be used to detect learning deficits in Parkinson's disease (PD). However, its clinical usefulness has not yet been thoroughly examined. Early detection of memory impairment in PD is essential for effective treatment. Therefore, this study aimed to provide BVMT-R Czech normative data for clinical use and to find the detection potential of the principal BVMT-R scores, including new learning indices, to capture the cognitive deficit in PD. Method: The BVMT-R were administered to a normative sample of 920 participants aged 17 to 95 years and to a clinical sample of 60 PD patients; 25 with mild cognitive impairment (PD-MCI) and 35 with normal cognition (PD-NC). In order to provide normative values, multiple regression analyses were employed, and to compare the clinical and control sample, Bayesian Hierarchical Linear Models were used. Results: The best model for regression-based norms showed to be with age + age2 + education + sex as predictors. From all learning indexes, L6 (sum of trials 1-3), followed by, L4 (sum of trials 1-3 multiplied by the difference between the highest and the lowest score) best differentiated between controls or PD-NC and PD-MCI. Conclusions: We provide regression-based normative values for BVMT-R that could be used in clinical settings and meta-analytic efforts. Furthermore, we revealed visuospatial learning and memory deficit in PD-MCI. We have also identified the most discriminative learning index adapted to BVMT-R.
- MeSH
- dospělí MeSH
- kognitivní dysfunkce etiologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- neuropsychologické testy normy MeSH
- Parkinsonova nemoc komplikace patofyziologie MeSH
- poruchy paměti etiologie patofyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- učení fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
We aimed to validate the Czech version of the MATRICS Consensus Cognitive Battery (MCCB). The MCCB is a test battery designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. The valid, reliable and replicable measurement of cognition in schizophrenia is of substantial importance for such clinical trial studies. We performed a psychometric analysis of the MCCB composite and domain scores based on ROC analysis of 67 schizophrenia patients and 67 age- and education-matched healthy controls from a total sample of 220 controls. Also, we correlated MCCB variables with scales measuring psychosocial functioning (Personal and Social Performance scale; PSP). The internal consistency of all 10 tests in the MCCB battery was good (Cronbach's α = 0.85 (95% CI [0.83, 0.88])). The discriminative validity for the detection of neurocognitive dysfunction in schizophrenia based on the area under the curve of MCCB composite T-score was ≥90% (95% CI [0.85, 0.96]) and all MCCB domains showed ps < .001. The MCCB global composite and the Speed of Processing domain score significantly predicted the PSP ratings. A confirmatory factor analysis on the whole control sample (N = 220) showed an optimal fit for a 6-factor in comparison to 1-factor solution. In conclusion, we found high discriminative validity for the Czech MCCB version, similar to the differentiation of schizophrenia versus healthy control groups in the original MCCB studies. We also established the factorial validity of the MCCB and showed that the overall composite of the MCCB predicts psychosocial functioning in the patient group.
- MeSH
- kognice MeSH
- konsensus MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- psychiatrické posuzovací škály MeSH
- schizofrenie (psychologie) MeSH
- schizofrenie * komplikace diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
