Five female patients had slowly progressing greyish-brown pigmentations without clinical inflammatory changes or infiltrations. The lesions were in interscapular region, some of them also on the neck, forearm, arms, chest and abdomen. Skin biopsy revealed in enlarged dermal papillae agglomerations of amyloid globules and melanophages. The clinical and microscopic picture in all patients suggested the diagnosis of macular amyloidosis. In three patients the manifestations were preceded by chafing at the site of subsequent skin affection. During an overall analysis of the mi pathogenetic units limited to individual dermal papillae. In the early stage in addition to amyloid marked hydropic degeneration of the stratum basale in the adjacent epidermis was present, in the mature unit only agglomerations of amyloid with melanophages and in the regressing unit in the dermal papula only few amyloid globules were found and the melanophages shifted from the papilla into the perivascular space.
- MeSH
- abnormality zubů MeSH
- alopecie MeSH
- nemoci prsů MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- dospělí MeSH
- genetická onemocnění kůže MeSH
- komplikace těhotenství MeSH
- kožní nemoci MeSH
- Check Tag
- dospělí MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- hyperplazie MeSH
- kožní nemoci MeSH
- lidé středního věku MeSH
- Check Tag
- lidé středního věku MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- bradavice patologie MeSH
- dospělí MeSH
- karcinom patologie MeSH
- nemoci rekta patologie MeSH
- prekancerózy patologie MeSH
- Check Tag
- dospělí MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
