• Publikační typ
• abstrakt z konference MeSH

In patients with obstructive sleep apnea (OSA) during obstructive events, episodes of hypoxia and hypercapnia may modulate the autonomic nervous system (ANS) by increasing sympathetic tone and irritability, which contributes to sympathovagal imbalance and ultimately dysautonomia. Because OSA can alter ANS function through biochemical changes, we can assume that heart rate variability (HRV) will be altered in patients with OSA. Most studies show that in both the time and frequency domains, patients with OSA have higher sympathetic components and lower parasympathetic dominance than healthy controls. These results confirm autonomic dysfunction in these patients, but also provide new therapeutic directions. Respiratory methods that modulate ANS, e.g., cardiorespiratory biofeedback, could be beneficial for these patients. Heart rate variability assessment can be used as a tool to evaluate the effectiveness of OSA treatment due to its association with autonomic impairment.

• MeSH
• autonomní nervový systém MeSH
• lidé MeSH
• obstrukční spánková apnoe * diagnóza   epidemiologie   terapie   MeSH
• polysomnografie MeSH
• srdeční frekvence fyziologie   MeSH
• veřejné zdravotnictví * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Although it is thought that obstructive sleep apnea (OSA) is worse during rapid eye movement (REM) sleep than in non-REM (NREM) sleep there are some uncertainties, especially about apnoe-hypopnoe-index (AHI). Several studies found no significant difference in AHI between both sleep stages. However, REM sleep is associated more with side sleeping compared to NREM sleep, which suggests that body position is a possible confounding factor. The main purpose of this study was to compare the AHI in REM and NREM sleep in both supine and lateral body position. A retrospective study was performed on 422 consecutive patients who underwent an overnight polysomnography. Women had higher AHI in REM sleep than NREM sleep in both supine (46.05+/-26.26 vs. 23.91+/-30.96, P<0.01) and lateral (18.16+/-27.68 vs. 11.30+/-21.09, P<0.01) body position. Men had higher AHI in REM sleep than NREM sleep in lateral body position (28.94+/-28.44 vs. 23.58+/-27.31, P<0.01), however, they did not reach statistical significance in supine position (49.12+/-32.03 in REM sleep vs. 45.78+/-34.02 in NREM sleep, P=0.50). In conclusion, our data suggest that REM sleep is a contributing factor for OSA in women as well as in men, at least in lateral position.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• obstrukční spánková apnoe diagnóza   etiologie   patofyziologie   MeSH
• polohování pacienta MeSH
• polysomnografie MeSH
• retrospektivní studie MeSH
• rizikové faktory MeSH
• sexuální faktory MeSH
• spánek REM * MeSH
• supinační poloha MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH

• Publikační typ
• abstrakty MeSH

• MeSH
• diabetes mellitus 2. typu komplikace   MeSH
• hyperglykemie diagnóza   etiologie   MeSH
• krevní glukóza analýza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• monitorování fyziologických funkcí metody   MeSH
• obstrukční spánková apnoe diagnóza   komplikace   terapie   MeSH
• polysomnografie využití   MeSH
• ventilace umělá s výdechovým přetlakem přístrojové vybavení   využití   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

• Publikační typ
• abstrakt z konference MeSH

• Publikační typ
• abstrakt z konference MeSH

Aims: There is no standardized protocol for measuring glycemic index (GI) that takes time-of-day eff ects intoaccount. The software DegifXL2 and Medtronic-Minimed's CGMSTM and Solutions TM, makes the GI calculationat breakfast and dinner time possible. The aim of this study was to assess the enhanced data processing software(DegifXL4) enabling the GI calculation at breakfast, lunch, afternoon snack and dinner times. Methods: The glucose levels of 20 healthy volunteers were monitored after they consumed either 50 g of glucoseor one of ten alternative foodstuff s either for breakfast and dinner or for lunch or snack. Within the 9-day test period,10 such meals were monitored in 3 replicates for each volunteer. Specifi cally, CGMSTM was used to monitor plasmaglucose levels at 5-minute intervals for a period of 120 min following the foodstuff ingestion. Results: Using the enhanced spreadsheed DegifXL 4, a total of 640 profi les were obtained and 491 (77 %) accomplishedthe criteria for further processing. The percentage of successful tests in each foodstuff varied from 57 to87 %. Conclusions: The use of the new software DegifXL4 off ers accurate GI estimates for foodstuff s eaten for breakfast,lunch, snacks and dinners in three replicates. In combination with the CGMS Solutions SoftwareTM is DegifXL4 anenhanced effi cient and comfortable way to routinely measure GI values.

• MeSH
• dospělí MeSH
• experimenty na lidech normy   statistika a číselné údaje   MeSH
• financování organizované MeSH
• glykemický index fyziologie   MeSH
• krevní glukóza izolace a purifikace   MeSH
• lidé MeSH
• metody výživy využití   MeSH
• monitorování fyziologických funkcí metody   využití   MeSH
• numerická analýza pomocí počítače přístrojové vybavení   MeSH
• počítače využití   MeSH
• software MeSH
• statistika jako téma MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH

Aims: Consumption of glucose or foodstuff s with high glycaemic index (GI) in persons with type 1 diabetes mellitus(PWD1) is a hot topic in present diabetology. The aim of our pilot prospective study was to assess the effi ciencyof empirically suggested simple algorithms for premeal boluses in PWD1 using insulin pumps and continuous glucosemonitoring (CGM). Methods: Six PWD1 (aged 46.2±15.09 y, diabetes duration 14.5±9.65 y, HbA1c/IFCC 6.3±1.59%, BMI 23.6±1.67kg/m2, mean±SD) on insulin pumps Paradigm 522/722 with RT-CGMS sensors (Medtronic MiniMed, Northridge, CA)underwent a 12-week CGM. In one week, subjects consumed 50g of carbohydrates in eleven alternative meals (ricesquares, dark chocolate, white bread, honey, glucose, ravioli with meat and Eidam cheese, mashed potatoes with fi shfi ngers, apricot dumplings with butter, spa waffl es, spalta squares, and tomato soup with pasta) eaten for breakfasts,lunches, snacks and dinners in order to calculate their GI. The insulin boluses were adjusted according to empiricallydefi ned algorithms. Average glucose levels and daily insulin doses over three one-week periods (before testing, testingand after testing) were compared. Results: During the observational period, the weekly averages of glucose levels (9.1±2.33 mmol/l vs. 9.2±2.30mmol/l vs. 9.0±2.43 mmol/l, respectively) and daily insulin doses (39.1± 8.14 IU/d vs. 39.7±10.7 IU/d vs. 38.6±9.97IU/d, respectively) were similar. One-week consumption of high GI foodstuff s had only a negligeable eff ect on averageglucose levels.Conclusion: The suggested algorithms for premeal insulin boluses appear to limit the risk of potential hyperglycaemiaresulting from intake of high GI foodstuff s.

• MeSH
• algoritmy MeSH
• ambulantní monitorování metody   využití   MeSH
• diabetes mellitus 1. typu dietoterapie   MeSH
• dospělí MeSH
• experimenty na lidech statistika a číselné údaje   MeSH
• financování organizované MeSH
• glykemický index fyziologie   MeSH
• hyperglykemie prevence a kontrola   MeSH
• inzulinové infuzní systémy využití   MeSH
• krevní glukóza izolace a purifikace   MeSH
• lidé MeSH
• pilotní projekty MeSH
• prospektivní studie MeSH
• rozvrh dávkování léků MeSH
• statistika jako téma MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH

• Publikační typ
• abstrakt z konference MeSH