OBJECTIVES: To report the clinical outcomes of the VictoTM (Promedon, Cordoba, Argentina) adjustable artificial urinary sphincter (AUS) implantation in a cohort of patients with severe urinary incontinence (UI) after prostate surgery. PATIENTS AND METHODS: This study enrolled patients with UI following prostate surgery who underwent a Victo implantation between May 2018 and December 2023. Patients were prospectively evaluated at baseline, and at 3 and 12 months after device activation, and thereafter annually. The 24-h pad-weight test (24hPWT) was used to assess severity of UI, while the Patient Global Impression of Improvement (PGI-I) and patient satisfaction according to a Likert scale were used to measure patient-reported outcomes. RESULTS: A total of 96 patients with a median (interquartile range [IQR]) age of 68 (65-72) years were included in the final analysis. The median (IQR) follow-up was 3 (1-4) years. In all, 10 patients completed the 5-year follow-up. After the treatment, we observed a significant reduction in 24hPWT by the median of 83% (P < 0.001) at 3 months and by a median of 79% (P < 0.001) at 3 years. According to the PGI-I, a total of 87%, 92%, 87%, 81%, 83%, and 50% (five of 10) of patients rated their condition/incontinence as 'very much improved', 'much improved' or 'little improved' at 3 months, 1-, 2-, 3-, 4-, and 5-year follow-up visits, respectively. The proportion of patients, who were 'very satisfied' or 'satisfied' with the treatment outcome was 79%, 80%, 75%, 69%, 80%, and 60% (six of 10) at 3 months, 1-, 2-, 3-, 4-, and 5-years, respectively. There were a total of 13 (14%) device failures during the follow-up period. CONCLUSION: In conclusion, our data suggest that Victo AUS significantly reduces the severity of UI after prostate surgery and provides a reasonably high patient-reported satisfaction with treatment outcomes at mid-term follow-up.

• MeSH
• inkontinence moči * chirurgie   terapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• pooperační komplikace MeSH
• prospektivní studie MeSH
• prostatektomie * škodlivé účinky   MeSH
• senioři MeSH
• spokojenost pacientů MeSH
• umělý močový svěrač * MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE: To estimate the timepoint of onset of the lower urinary tract symptoms (LUTS) over the course of multiple sclerosis (MS), determine which of the LUTS typically appears first, and identify risk factors for early development of LUTS in patients with MS (PwMS). METHODS: This observational study included 1167 PwMS. The participants were predominantly women (72%), median age was 45 (IQR 36;53) years, and median disease duration was 11 (IQR 6;16) years. Inclusion criteria were age over 18 years, proven MS diagnosis according to McDonald ́s criteria (2017), and complete medical records since establishment of MS diagnosis. A structured in-person interview addressing the study objectives was performed during routine follow-up visit. The data were cross-checked with the medical records. RESULTS: Median LUTS-free survival time after MS diagnosis has been made, was 8 (IQR 7;10) years. Storage, voiding and postmicturition symptoms were identified as a first LUTS in 549/709 (77%), 130/709 (18%), and 30/709 (4.2%) PwMS, respectively. Most frequently reported first LUTS was urgency 360 (51%). Using multivariate analysis, higher age, higher degree of disability, and presence of cerebellar and/or pyramidal symptoms at the time of MS diagnosis were significantly associated with shorter LUTS-free survival. No significant relationship between LUTS-free survival and sex or type of MS was found. CONCLUSIONS: Our data show, that LUTS occur after median time of 8 years after MS diagnosis, with urgency being the most frequently reported first LUTS.

• MeSH
• časové faktory MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• rizikové faktory MeSH
• roztroušená skleróza * komplikace   MeSH
• symptomy dolních močových cest * etiologie   epidemiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH

PURPOSE: This study aimed to determine hearing thresholds in an otologically normal population without occupational noise exposure aged 18 to 64 years using extended high-frequency audiometry (EHFA). METHODS: Individuals from the general population who have never had hearing problems and whose job was not associated with noise exposure were included in the study and classified by age into 5 categories: 18-24 and, further, by 10 years of age. Each of these groups was further divided according to gender. All subjects underwent tympanometry, conventional pure-tone audiometry within the 0.125-8 kHz range, and extended high-frequency audiometry within the 9-16 kHz range, performed according to the standards. The significance level for statistical testing was set at 5%. RESULTS: Here, we established hearing thresholds in an otologically healthy population within the extended high-frequency (EHF) range (9-16 kHz). We found the EHFA to be a highly sensitive method for early detection of hearing loss, with hearing thresholds decreasing as soon as 35 years of age. In males, the hearing thresholds grew with age more rapidly than in women. The ability to respond at EHF gradually decreased with age and increasing frequency. CONCLUSION: Our results can help improve the knowledge of EHF hearing thresholds for individual sexes and age groups. So far, the standard 7029:2017 is not binding and, moreover, it only reaches up to the frequency of 12.5 kHz. EHFA is a highly sensitive method for the evaluation of hearing loss depending on age and sex.

• MeSH
• akustické impedanční testy MeSH
• audiometrie čistými tóny MeSH
• audiometrie MeSH
• dítě MeSH
• dospělí MeSH
• hluchota * MeSH
• lidé MeSH
• nedoslýchavost z hluku * diagnóza   MeSH
• nedoslýchavost * diagnóza   MeSH
• sluch MeSH
• sluchový práh MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Two-dimensional (2D) and three-dimensional (3D) speckle-tracking echocardiography (STE) enables assessment of myocardial function. Here, we examined the agreement between 2D and 3D STE measurement of a global longitudinal strain (GLS) in patients with normal left ventricle, reduced ejection fraction, and cardiac pacing. METHODS: Our analysis included 90 consecutive patients (59% males; average age: 73.2 ± 11.2 years) examined between May 2019-December 2020, with valid 2D and 3D loops for further speckle-tracking strain analysis. Linear regression, Pearson correlation, and a Bland-Altman plot were used to quantify the association between 2D and 3D GLS and related segments, using the 17-segment American Heart Association (AHA) model. Analyses were performed in the entire study group and subgroups. Intra- and inter-observer variability of 2D and 3D GLS measurement was also performed in all participants. RESULTS: We observed a strong correlation between 2D and 3D GLS measurements (R = 0.76, p < 0.001), which was higher in males (R = 0.78, p < 0.001) than females (R = 0.69, p < 0.001). Associated segment correlation was poor (R = 0.2-0.5, p < 0.01). The correlation between 2D and 3D GLS was weaker in individuals with ventricular pacing of >50% (R = 0.62, p < 0.001) than <50% (R = 0.8, p < 0.001), and in patients with LVEF of <35% (R = 0.69, p = 0.002) than >35% (R = 0.72, p < 0.001). Intra-observer variability for 2D and 3D GLS was 2 and 2.3%, respectively. Inter-observer variability for 2D and 3D GLS was 3.8 and 3.6%, respectively Conclusion: Overall 2D and 3D GLS were closely associated but not when analyzed per segment. It seems that GLS comparison is more representative of global shortening than local displacement. Right ventricular pacing and reduced left ventricular ejection fraction were associated with a reduced correlation between 2D and 3D GLS.

• Publikační typ
• časopisecké články MeSH

Cíl: Nedoslýchavost má významný dopad na mezilidskou komunikaci. Jedná se o příznak, který může být způsoben řadou rizikových faktorů. Jedním z nich je kouření. Cílem práce je zjistit, zdali existuje souvislost mezi kouřením a nedoslýchavostí a určit míru asociace mezi kouřením a nedoslýchavostí spolu s proměnnými, jako je pohlaví a věk. Metodika: Audiometricky byly srovnávány prahy sluchu na frekvencích 500, 1 000, 2 000, 4 000, 6 000 a 8 000 Hz dle věku. Výskyt nedoslýchavosti a sluchové prahy byly porovnávány podle věkových skupin a úrovně kouření dle Brinkmanova indexu (BI). Průměrné ztráty sluchu na jednotlivých frekvencích v souvislosti s kouřením byly porovnány mezi muži a ženami ve 4 věkových skupinách. Výsledky: Dle významných statistických rozdílů byl pozorován vliv kouření na práh sluchu častěji u žen než u mužů. Vliv kouření na prahy sluchu byl statisticky prokázán u mužů s BI ≥ 400 ve věku 20-44 let na frekvencích 500-2 000 Hz a ve věkové skupině 45-54 let na frekvencích 1000-6 000 Hz, u mužů s BI ≤ 400 ve věkové skupině 55-64 let a 65-74 let na frekvenci 500 Hz. U žen s BI ≥ 400 byl vliv kouření na prahy sluchu prokázán u skupiny 45-54 let na frekvencích 500, 2 000, 4 000, 6 000 a 8 000 Hz, u skupiny 55-64 let s BI ≤ 400 na frekvencích 500, 1 000, 4 000, 6 000 a 8 000 Hz a u skupiny 65-74 let s BI ≥ 400 na frekvencích 500-4 000 Hz. Závěr: Incidence nedoslýchavosti se zvyšuje a stává se aktuálním globálním problémem. Vzniká z multifaktoriálních příčin, a proto je nutné zaměřit se na ty, které jsou dobře preventabilní, jako je hluk a kouření.

Objective: Hearing loss has a significant impact on interpersonal communication. It is a symptom that can be caused by many risk factors, including smoking. This work has aimed to determine whether there is a connection between smoking and hearing impairment and to determine the degree of association, considering variables such as gender and age. Methodology: Hearing thresholds at frequencies of 500, 1,000, 2,000, 4,000, 6,000, and 8,000 Hz were compared using audiometry. Prevalences of hearing loss occurrence and hearing thresholds were compared according to age groups and smoking levels determined by the Brinkman index (BI). The average hearing thresholds at individual frequencies depending on smoking were compared between men and women divided in four different age groups. Results: According to significant statistical differences, the effect of smoking on hearing thresholds was observed more often in women than in men. The effect of smoking on hearing loss was statistically proven in men with BI ≥ 400 aged 20-44 years at frequencies of 500-2,000 Hz, in men aged 45-54 years at frequencies of 1,000-6,000 Hz, and in men with BI ≤ 400 aged 55-64 years and 65-74 years at 500 Hz. In women with BI ≥ 400, the effect of smoking on hearing thresholds was detected in the 45-54 age group at frequencies of 500, 2,000, 4,000, 6,000, and 8,000 Hz, in women with BI ≤ 400 aged 55-64 years at 500, 1,000, 4,000, 6,000, and 8,000 Hz, and in women with BI ≥ 400 aged 65-74 years at frequencies of 500-4,000 Hz. Conclusion: The incidence of hearing loss is increasing and it is a problem of global extent. As it can be caused by multifactorial causes, it is necessary to focus on those that are well preventable, such as noise and smoking.

• MeSH
• audiometrie MeSH
• dospělí MeSH
• kouření cigaret * škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nedoslýchavost * diagnóza   etiologie   MeSH
• průzkumy a dotazníky MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH

Úvod: Nedoslýchavost je třetí nejčastější chronickou nemocí u seniorů a je jednou z nejčastějších příčin poklesu kognitivních funkcí ve vyšším věku. Cílem práce bylo zjistit, zda je zkrácená verze standardizovaného dotazníku Hearing Handicap Inventory (HHI-S) schopna odhalit problémy se sluchem u dospělých v ordinaci praktického lékaře. Metodika: Sluch byl vyšetřen pomocí vysokofrekvenční audiometrie a byla vyplněna zkrácená verze dotazníku sluchového postižení Hearing Handicap Inventory (HHI-S). Pro zjištění schopnosti dotazníku odhalit sluchový hendikep byli probandi dále rozděleni na osoby s průměrnou ztrátou sluchu na lépe slyšícím uchu v jednotlivých frekvenčních skupinách do 25 dB (normální sluch) a na větší než 25 dB (nedoslýchavost). Byly zvoleny celkem čtyři frekvenční skupiny (0,5–4 kHz, 6–8 kHz, 9–12,5 kHz a 14–16 kHz). Výsledky: Bylo vyšetřeno 240 mužů (47,7 %) a 263 žen (52,3 %) ve věku 18–64 let, kteří nebyli sledováni v ordinaci ORL lékaře pro nedoslýchavost. Soubor byl rozdělen na dvě skupiny: od 18 do 39 let (244 osob) a nad 40 let (259 osob). Nejvyššího průměrného skóre v dotazníku dosahovaly osoby u obou věkových skupin na nejnižších hodnocených frekvencích (0,5–4 kHz). Do 40 let dosahovaly osoby průměrně 8 bodů a nad 40 let 9 bodů. Bylo zjištěno, že osoby mladší mají lepší průměrné skóre bodů oproti osobám starším, a to jak u osob s normálním sluchem, tak u osob s nedoslýchavostí (p < 0,001). Průměrný počet bodů z dotazníku HHI-S při normálním sluchu neroste s vyššími frekvencemi, ale zůstává téměř totožný. U nedoslýchavých však průměrné skóre se zvyšujícími se frekvencemi klesá. Závěr: Včasné odhalení nedoslýchavosti významně zlepší kvalitu života a sníží riziko ztráty kognitivních funkcí. Dotazník HHI-S se jeví v ordinaci praktického lékaře jako jeden z rychlých, levných a jednoduchých nástrojů k odhalení sluchové vady zejména u osob s nediagnostikovanou nedoslýchavostí. U mladších osob s normálním sluchem, ale s přítomností rizikových faktorů však dotazník nemá tak vysokou citlivost, proto by bylo vhodné zvážit audiometrické vyšetření k odhalení počínající ztráty sluchu.

Introduction: Hearing loss is the 3rd most common chronic disease in the elderly and is one of the most common causes of cognitive decline in older age. The aim was to find out whether the shortened version of the standardized questionnaire Hearing Handicap Inventory (HHI-S) is able to detect hearing problems in adults in a general practitioner’s office. Methods: All probands underwent extended high-frequency audiometry and fillet out a questionnaire (a shortened version of the Hearing Handicap Inventory (HHI-S)). To determine the ability of the questionnaire to detect hearing handicap, the probands were divided into persons with an average hearing loss in the better hearing ear in individual frequency groups up to 25dB (normal hearing) and greater than 25dB (hearing loss). It were created 4 frequency groups (0.5–4 kHz, 6–8 kHz, 9–12.5 kHz and 14–16 kHz). Results: It was examined 240 men (47.7%) and 263 women (52.3%) aged 18–64 years, who were not monitored in an otorhinolaryngologist’s office for hearing loss. The file was divided into 2 groups by age: from 18 to 39 years (244 people) and over 40 years (259 people). The highest average score in the questionnaire was achieved by persons in both age groups at the lowest evaluated frequencies (0.5–4 kHz). People under 40 scored an average of 8 points and over 40 scored 9 points. Younger subjects were found to have a better mean score compared to older subjects, both in normal hearing and hearing impaired subjects (p < 0.001). The average number of points from the HHI-S questionnaire in normal hearing does not increase with higher frequencies, but remains almost identical. However, the average score decreases with increasing frequencies by people with hearing loss. Conclusion: Early detection of hearing loss will significantly improve the quality of life and reduce the risk of cognitive function loss. The HHI-S questionnaire appears in the general practitioner’s office as one of the quick, cheap and simple tools to detect hearing impairment, especially in people with undiagnosed hearing loss. However, in younger people with normal hearing but with the presence of risk factors, the questionnaire does not have such a high sensitivity, so it would be advisable to consider an audiometric examination to detect beginning hearing loss.

• MeSH
• audiometrie metody   MeSH
• lidé MeSH
• nedoslýchavost * diagnóza   MeSH
• průzkumy a dotazníky MeSH
• vysokofrekvenční nedoslýchavost diagnóza   MeSH
• Check Tag
• lidé MeSH

For this study, high-frequency audiometry was used to compare the hearing thresholds, with respect to age, among women exposed to noise in their working environment, as well as those not exposed to such noise. The cohort comprised 243 women (average age 36.2 years), of which 88 women were employed in a noisy (LAeq,8h 85-105 dB) workplace, while 155 women did not experience noise. Age categories were determined according to the World Health Organization (Geneva, Switzerland). Hearing thresholds were measured at frequencies of 0.125-16 kHz. Higher hearing thresholds were found in the youngest age groups (18-29 and 30-44 years) among those exposed to noise, as compared to those who were not. The difference in hearing thresholds between the exposed and unexposed groups increased with age, as well as with the frequencies. The highest difference in hearing thresholds for these age categories was measured at 11.25 kHz. The oldest age group (45-63 years) exposed to noise showed lower hearing thresholds than the unexposed group at all frequencies from 4 kHz to 16 kHz. High-frequency audiometry can be used for the early detection of increased hearing thresholds at high frequencies. High-frequency audiometry could be included in preventive programs, especially for younger people exposed to noise, in order to enable earlier detection of noise-induced hearing loss.

• MeSH
• audiometrie čistými tóny MeSH
• dospělí MeSH
• hluk na pracovišti * škodlivé účinky   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nedoslýchavost z hluku * diagnóza   epidemiologie   etiologie   MeSH
• pracoviště MeSH
• sluchový práh MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Švýcarsko MeSH