• Publication type
• Abstracts MeSH

Alkaline sucrose solution was demonstrated to be a good solvent for the solubilization of water-insoluble drugs. At high concentration and alkaline pH, sucrose solubilizes water-insoluble molecules through intramolecular conformations. Tetracyline and chloramphenicol, when dissolved in alkaline sucrose solution, retained their bactericidal activity. Gel permeation-chromatography analysis and atomic-force-microscopy studies confirmed the formation of sucrose-antibiotics complex.

• MeSH
• Alkalies chemistry   MeSH
• Anti-Bacterial Agents administration & dosage   chemistry   MeSH
• Bacteria drug effects   MeSH
• Chloramphenicol administration & dosage   chemistry   MeSH
• Financing, Organized MeSH
• Pharmaceutical Solutions MeSH
• Drug Delivery Systems methods   MeSH
• Microbial Sensitivity Tests MeSH
• Solvents chemistry   MeSH
• Solubility MeSH
• Sucrose chemistry   MeSH
• Tetracyclines administration & dosage   chemistry   MeSH
• Water chemistry   MeSH

• MeSH
• Coloring Agents chemistry   MeSH
• Research Support as Topic MeSH
• Glucaric Acid MeSH
• Soil Pollutants MeSH
• Copper chemistry   MeSH
• Environmental Pollution prevention & control   MeSH

• MeSH
• Research Support as Topic MeSH
• Microscopy, Electron, Scanning utilization   MeSH
• Cyanobacteria metabolism   MeSH
• In Vitro Techniques MeSH
• Hydrogen metabolism   MeSH

• MeSH
• Copper chemistry   MeSH
• Oxidation-Reduction MeSH
• Hydrogen Peroxide chemistry   MeSH
• Polycyclic Aromatic Hydrocarbons analysis   chemistry   MeSH