The transmyocardial turnover of lactate, oxidized and reduced glutathione, malondialdehyde, and the isoenzyme CK-MB before and after restoration of myocardial blood flow was studied in 18 patients undergoing coronary artery surgery. Of this number, ten patients were given oral allopurinol preoperatively; the remaining patients made up the control group. Allopurinol significantly reduced the levels of free oxygen radicals. The enzymatic methods employed did not make it possible to evaluate the protective effect of allopurinol on reperfusion myocardial injury.
- MeSH
- alopurinol aplikace a dávkování MeSH
- aplikace orální MeSH
- funkce levé komory srdeční účinky léků MeSH
- glutathion krev MeSH
- izoenzymy MeSH
- koronární bypass * MeSH
- koronární cirkulace účinky léků MeSH
- kreatinkinasa krev MeSH
- kyselina mléčná MeSH
- laktáty krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- malondialdehyd krev MeSH
- premedikace MeSH
- reaktivní formy kyslíku metabolismus MeSH
- reperfuzní poškození myokardu farmakoterapie enzymologie MeSH
- volné radikály MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- randomizované kontrolované studie MeSH
- MeSH
- fibrinolýza metody MeSH
- infarkt myokardu MeSH
- lidé MeSH
- streptokinasa terapeutické užití MeSH
- Check Tag
- lidé MeSH
- MeSH
- fibrinolýza metody MeSH
- infarkt myokardu MeSH
- lidé MeSH
- streptokinasa terapeutické užití MeSH
- Check Tag
- lidé MeSH
In the authors' opinion, profound myocardial hypothermia is imperative in myocardial protection while the aorta is cross-clamped. They based their own protection method, beside using a single dose of crystalloid cardioplegic solution, on very efficient topical cooling, by which myocardial temperature is reduced to below 15 degrees C. Very efficient topical cooling is achieved by a high flow (2 l/min) of continuously cooled fluid (0 degrees C- +2 degrees C). The great temperature-reducing capacity of the cooling system is due to 10-15 metres long metal coil tubing which is immersed in an ice-salt cold bath. The water pump placed in the bath makes heat exchange even more efficient. The described method of myocardial protection with stable profound myocardial hypothermia safely prolongs the ischaemic time during operation to more than two hours.
- MeSH
- koronární bypass * MeSH
- lidé MeSH
- riziko MeSH
- terapeutická hypotermie metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
