- MeSH
- Angelica sinensis MeSH
- Dioscorea MeSH
- fytoterapie metody MeSH
- hormonální substituční terapie MeSH
- klimakterium * fyziologie účinky léků MeSH
- komplementární terapie metody MeSH
- kvalita života MeSH
- lidé MeSH
- menopauza * fyziologie účinky léků MeSH
- Trifolium MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Klíčová slova
- smldinec chlupatý, Dioscorea villosa,
- MeSH
- Dioscorea MeSH
- fytoterapie * MeSH
- hormonální substituční terapie * MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- MeSH
- biopotraviny MeSH
- Colocasia MeSH
- Dioscorea MeSH
- Ipomoea batatas MeSH
- maniok MeSH
- Solanum tuberosum MeSH
- Publikační typ
- populární práce MeSH
Analogs of pregnanolone (3α-hydroxy-5β-pregnan-20-one), modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely by azide (17α- and 17β-azido-5β-androstan-3α-ol), compounds with its part replaced (20-azido-21-nor-5β-pregnan-3α-ol), and compounds with keto group only replaced ((20R)- and (20S)-20-azido-5β-pregnan-3α-ol) were synthesized using tosylate displacements with sodium azide or Mitsunobu reaction with azoimide. All five azido steroids were converted into corresponding sulfates. Subsequent tests for inhibition of glutamate induced response on NMDA receptors revealed that modification of pregnanolone sulfate side chain with azide did not disturb the activity and some of sulfates tested were more active than parent compound.
