Purpose: To investigate the effect of patient specific vessel cooling on head and neck hyperthermia treatment planning (HTP). Methods and materials: Twelve patients undergoing radiotherapy were scanned using computed tomography (CT), magnetic resonance imaging (MRI) and contrast enhanced MR angiography (CEMRA). 3D patient models were constructed using the CT and MRI data. The arterial vessel tree was constructed from the MRA images using the 'graph-cut' method, combining information from Frangi vesselness filtering and region growing, and the results were validated against manually placed markers in/outside the vessels. Patient specific HTP was performed and the change in thermal distribution prediction caused by arterial cooling was evaluated by adding discrete vasculature (DIVA) modeling to the Pennes bioheat equation (PBHE). Results: Inclusion of arterial cooling showed a relevant impact, i.e., DIVA modeling predicts a decreased treatment quality by on average 0.19 °C (T90), 0.32 °C (T50) and 0.35 °C (T20) that is robust against variations in the inflow blood rate (|ΔT| < 0.01 °C). In three cases, where the major vessels transverse target volume, notable drops (|ΔT| > 0.5 °C) were observed. Conclusion: Addition of patient-specific DIVA into the thermal modeling can significantly change predicted treatment quality. In cases where clinically detectable vessels pass the heated region, we advise to perform DIVA modeling.

• MeSH
• cévy anatomie a histologie   diagnostické zobrazování   MeSH
• indukovaná hypertermie * MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• nádory hlavy a krku krevní zásobení   diagnostické zobrazování   terapie   MeSH
• počítačem asistovaná terapie MeSH
• počítačová rentgenová tomografie MeSH
• počítačové modelování podle konkrétního pacienta * MeSH
• studie proveditelnosti MeSH
• teplota MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

BACKGROUND: Cutaneous lymphomas co-expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer- (NK)/T-cell lymphomas and anaplastic large-cell lymphomas (ALCLs), two entities with widely disparate clinical behavior. METHODS: We present a case of an immunocompetent 57-year-old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30+ and CD56+ T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus-secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE. RESULTS: After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high-dose chemotherapy with autologous peripheral blood stem-cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years. CONCLUSIONS: This is the first CD30+ and CD56+ primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK-/T-cell lymphoma.

• MeSH
• antigen CD56 analýza   MeSH
• antigen Ki-1 analýza   MeSH
• čelo MeSH
• difúzní velkobuněčný B-lymfom farmakoterapie   imunologie   patologie   MeSH
• financování organizované MeSH
• histiocyty cytologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory hlavy a krku farmakoterapie   imunologie   krevní zásobení   patologie   MeSH
• nádory kůže farmakoterapie   imunologie   krevní zásobení   patologie   MeSH
• neutrofily cytologie   MeSH
• skalp inervace   krevní zásobení   patologie   účinky léků   MeSH
• transplantace kmenových buněk MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH

• MeSH
• arteriae carotides MeSH
• arteriovenózní malformace terapie   MeSH
• dítě MeSH
• dospělí MeSH
• epistaxe terapie   MeSH
• hemangiom krevní zásobení   terapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• nádory hlavy a krku krevní zásobení   terapie   MeSH
• senioři MeSH
• terapeutická embolizace metody   přístrojové vybavení   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH