- Klíčová slova
- avelumab,
- MeSH
- humanizované monoklonální protilátky aplikace a dávkování MeSH
- imunoterapie MeSH
- inhibitory kontrolních bodů aplikace a dávkování MeSH
- lidé MeSH
- lymfadenopatie diagnostické zobrazování patologie MeSH
- lymfatické uzliny diagnostické zobrazování patologie MeSH
- Merkelův nádor * chirurgie diagnostické zobrazování farmakoterapie patologie MeSH
- počítačová rentgenová tomografie MeSH
- progrese nemoci MeSH
- protinádorové látky imunologicky aktivní * aplikace a dávkování MeSH
- senioři MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
PURPOSE: To detect the expression of programmed death-ligand 1 (PD-L1) in Merkel cell carcinoma (MCC) and to determine the prognostic influence of the PD-L1 expression. METHODS: A total of 13 patients with MCC were retrospectively evaluated (12 patients with primary skin lesion, one patient was diagnosed as unknown primary MCC). All patients underwent surgical resection. PD-L1 was determinated by imunohistochemistry. Immunostaining results were evaluated semiquantitatively. The prognostic influence of the expression of PD-L1 on overall survival (OS) was calculated with the Kaplan-Meier method and log-rank test. RESULTS: PD-L1 positivity was detected in 8 patients (61.5%), in all cases the result was 1+. PD-L1 negativity was shown in the remaining 5 patients. In patients with PD-L1 positivity median OS was 42.1 months (95% CI 9.3-42.1) compared with median OS of 9.4 months (95% CI 2.1-80.9) in the group of patients without PD-L1 positivity (p=0.417). CONCLUSIONS: PD-L1 positivity was found in 61.5% of patients with MCC. No prognostic significance of PD-L1 expression for OS was demonstrated.
- MeSH
- antigeny CD274 genetika MeSH
- dospělí MeSH
- Kaplanův-Meierův odhad MeSH
- lidé středního věku MeSH
- lidé MeSH
- Merkelův nádor diagnóza diagnostické zobrazování genetika patologie MeSH
- přežití po terapii bez příznaků nemoci MeSH
- prognóza * MeSH
- regulace genové exprese u nádorů genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- staging nádorů MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The incidence of Merkel cell carcinoma has tended to increase worldwide in recent years. Merkel cell carcinoma is a rare tumor of the skin that occurs mainly in the sun exposed sites. The malignant reversal of Merkel cells is currently associated with an infection caused by a Merkel cell polyomavirals. In some cases, the disease may have a relatively inconspicuous clinical picture in the initial phase, which is in contrast to its extensive microscopic propagation. For this reason, the risk of late diagnosis or insufficient primary surgery is increased. The diagnostic standard is histological and, in particular, immunohistochemical examination of tumor tissue samples. Merkel cell carcinoma is a marked tendency to local recurrence and early development of metastases in regional lymph nodes, followed by generalization. The basis of treatment is radical excision of the tumor by in most cases by adjuvant radiotherapy targeted at primary place of occurrence and the area of regional draining lymph nodes. The effectiveness of different chemotherapeutic protocols in Merkel cell carcinoma is mostly low and the median survival is low. From a prognostic point of view, Merkel cell carcinoma plays the most important role of staging the tumor at the time of capture. The suspected lesions in the area around the eye, eyelid and orbit need to indicate adequate therapeutic approach that the detection of the disease at the earliest stage. The authors describe the clinical experience in 2 patients with Merkel cell carcinoma of the eyelid and orbit.
- Klíčová slova
- orbitotomie,
- MeSH
- cisplatina terapeutické užití MeSH
- diferenciální diagnóza MeSH
- etoposid terapeutické užití MeSH
- fatální výsledek MeSH
- histologické techniky metody MeSH
- komorbidita MeSH
- lidé MeSH
- Merkelův nádor * chirurgie diagnostické zobrazování etiologie patologie radioterapie terapie MeSH
- nádory očního víčka * chirurgie diagnostické zobrazování patologie radioterapie terapie MeSH
- nádory orbity chirurgie diagnostické zobrazování patologie radioterapie terapie MeSH
- počítačová rentgenová tomografie metody MeSH
- prognóza MeSH
- progrese nemoci MeSH
- senioři MeSH
- stupeň nádoru metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
