Cardiac atrophy is the most common complication of prolonged application of the left ventricle (LV) assist device (LVAD) in patients with advanced heart failure (HF). Our aim was to evaluate the course of unloading-induced cardiac atrophy in rats with failing hearts, and to examine if increased isovolumic loading obtained by intraventricular implantation of an especially designed spring expander would attenuate this process. Heterotopic abdominal heart transplantation (HTx) was used as a rat model of heart unloading. HF was induced by volume overload achieved by creation of the aorto-caval fistula (ACF). The degree of cardiac atrophy was assessed as the weight ratio of the heterotopically transplanted heart (HW) to the control heart. Isovolumic loading was increased by intraventricular implantation of a stainless steel three-branch spring expander. The course of cardiac atrophy was evaluated on days 7, 14, 21, and 28 after HTx Seven days unloading by HTx in failing hearts sufficed to substantially decrease the HW (-59 ± 3%), the decrease progressed when measured on days 14, 21, and 28 after HTx Implantation of the spring expander significantly reduced the decreases in whole HW at all the time points (-39 ± 3 compared with -59 ± 3, -52 ± 2 compared with -69 ± 3, -51 ± 2 compared with -71 ± 2, and -44 ± 2 compared with -71 ± 3%, respectively; P<0.05 in each case). We conclude that the enhanced isovolumic heart loading obtained by implantation of the spring expander attenuates the development of unloading-induced cardiac atrophy in the failing rat heart.
- MeSH
- aorta chirurgie MeSH
- atriální natriuretický faktor genetika metabolismus MeSH
- atrofie metabolismus patofyziologie prevence a kontrola chirurgie MeSH
- biologické markery metabolismus MeSH
- design vybavení MeSH
- experimentální implantáty MeSH
- exprese genu MeSH
- fibroblastový růstový faktor 2 genetika metabolismus MeSH
- heterotopická transplantace MeSH
- krysa rodu rattus MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- píštěle MeSH
- potkani inbrední LEW MeSH
- přenašeč glukosy typ 1 genetika metabolismus MeSH
- sarkoplazmatická Ca2+-ATPáza genetika metabolismus MeSH
- srdce patofyziologie MeSH
- srdeční komory patofyziologie chirurgie MeSH
- srdeční selhání metabolismus patofyziologie chirurgie terapie MeSH
- tkáňové expandéry * MeSH
- transplantace srdce * MeSH
- vena cava superior chirurgie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- atriální natriuretický faktor genetika MeSH
- cerebrovaskulární poruchy etiologie MeSH
- fenotyp MeSH
- hypertenze genetika komplikace MeSH
- krysa rodu rattus MeSH
- lidé MeSH
- mapování chromozomů MeSH
- modely nemocí na zvířatech MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH
- MeSH
- atriální natriuretický faktor genetika MeSH
- hypertenze MeSH
- krevní tlak MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- srovnávací studie MeSH
