• MeSH
• chlorid sodný krev   metabolismus   MeSH
• deoxykortikosteron aplikace a dávkování   MeSH
• dieta statistika a číselné údaje   MeSH
• finanční podpora výzkumu jako téma MeSH
• hydrogenuhličitan sodný krev   metabolismus   MeSH
• hypertenze etiologie   chemicky indukované   MeSH
• krevní tlak MeSH
• krysa rodu rattus MeSH
• potkani Wistar MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• zvířata MeSH

Linkage studies in the fawn-hooded hypertensive rat have suggested that genes influencing susceptibility to hypertension-associated renal failure may exist on rat chromosome 1q. To investigate this possibility in a widely used model of hypertension, the spontaneously hypertensive rat (SHR), we compared susceptibility to hypertension-induced renal damage between an SHR progenitor strain and an SHR congenic strain that is genetically identical except for a defined region of chromosome 1q. Backcross breeding with selection for the markers D1Mit3 and Igf2 on chromosome 1 was used to create the congenic strain (designated SHR.BN-D1Mit3/Igf2) that carries a 22 cM segment of chromosome 1 transferred from the normotensive Brown Norway rat onto the SHR background. Systolic blood pressure (by radiotelemetry) and urine protein excretion were measured in the SHR progenitor and congenic strains before and after the induction of accelerated hypertension by administration of DOCA-salt. At the same level of DOCA-salt hypertension, the SHR.BN-D1Mit3/Igf2 congenic strain showed significantly greater proteinuria and histologically assessed renal vascular and glomerular injury than the SHR progenitor strain. These findings demonstrate that a gene or genes that influence susceptibility to hypertension-induced renal damage have been trapped in the differential chromosome segment of the SHR.BN-D1Mit3/Igf2 congenic strain. This congenic strain represents an important new model for the fine mapping of gene(s) on chromosome 1 that affect susceptibility to hypertension-induced renal injury in the rat.

• MeSH
• časové faktory MeSH
• chromozomy * genetika   MeSH
• deoxykortikosteron aplikace a dávkování   MeSH
• genetická predispozice k nemoci * MeSH
• genetická vazba MeSH
• interpretace statistických dat MeSH
• krysa rodu rattus MeSH
• kuchyňská sůl aplikace a dávkování   MeSH
• ledviny patologie   MeSH
• lidé MeSH
• mapování chromozomů * MeSH
• potkani inbrední BN MeSH
• potkani inbrední SHR * genetika   MeSH
• proteinurie diagnóza   MeSH
• renální hypertenze * genetika   moč   patologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• lidé MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• práce podpořená grantem MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• srovnávací studie MeSH

Young and adult uninephrectomized male rats (aged 25 and 87 days respectively) were exposed to an increased salt intake (1% saline as the only drinking fluid) either alone or in combination with DOCA-treatment for 25 and 46 days respectively. Age dependent differences of interrelationships between saline intake (SI), blood pressure (BP) and kidney weight (KW) were studied during development of salt and DOCA-salt hypertension to specify possible factors involved in the higher susceptibility of the young rats to these regimes. Correlation analysis was employed using the step-wise regression procedure. Only in the young rats did saline treatment induce an increase in KW, which preceded the development of mild hypertension. This age group also responded to DOCA-saline treatment with a more pronounced increase in both BP and KW. SI was higher in the young than adult rats exposed to either saline or DOCA-saline treatment. This, however, does not account by itself for the higher hypertensive response of the young rats, since there was no primary relationship between SI and BP in the hypertensive groups. Increase in KW accompanying development of hypertension was dependent on BP in the young rats and on SI in adult rats. This indicates that saline and DOCA-saline treatment renders the kidneys of young rats more sensitive to damaging effects of BP, which play a part in the more pronounced hypertensive response.

• MeSH
• deoxykortikosteron aplikace a dávkování   škodlivé účinky   MeSH
• homeostáza účinky léků   MeSH
• hypertenze patofyziologie   MeSH
• krevní tlak účinky léků   MeSH
• krysa rodu rattus MeSH
• ledviny patofyziologie   MeSH
• sodík aplikace a dávkování   škodlivé účinky   MeSH
• tělesná hmotnost MeSH
• věkové faktory MeSH
• velikost orgánu MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• časové faktory MeSH
• deoxykortikosteron aplikace a dávkování   MeSH
• homologní transplantace MeSH
• karcinom Walkerův 256 patofyziologie   MeSH
• kortison aplikace a dávkování   MeSH
• krysa rodu rattus MeSH
• lymfatické metastázy MeSH
• nadledviny patofyziologie   MeSH
• testikulární nádory patofyziologie   MeSH
• transplantace nádorů MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH