- MeSH
- fyziologie výživy MeSH
- histamin fyziologie metabolismus škodlivé účinky MeSH
- histidin * fyziologie metabolismus MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- populární práce MeSH
L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system. Several HIS-rich proteins (e.g., haemoproteins, HIS-rich glycoproteins, histatins, HIS-rich calcium-binding protein, and filaggrin), HIS-containing dipeptides (particularly carnosine), and methyl- and sulphur-containing derivatives of HIS (3-methylhistidine, 1-methylhistidine, and ergothioneine) have specific functions. The unique chemical properties and physiological functions are the basis of the theoretical rationale to suggest HIS supplementation in a wide range of conditions. Several decades of experience have confirmed the effectiveness of HIS as a component of solutions used for organ preservation and myocardial protection in cardiac surgery. Further studies are needed to elucidate the effects of HIS supplementation on neurological disorders, atopic dermatitis, metabolic syndrome, diabetes, uraemic anaemia, ulcers, inflammatory bowel diseases, malignancies, and muscle performance during strenuous exercise. Signs of toxicity, mutagenic activity, and allergic reactions or peptic ulcers have not been reported, although HIS is a histamine precursor. Of concern should be findings of hepatic enlargement and increases in ammonia and glutamine and of decrease in branched-chain amino acids (valine, leucine, and isoleucine) in blood plasma indicating that HIS supplementation is inappropriate in patients with liver disease.
- MeSH
- amoniak metabolismus MeSH
- atopická dermatitida terapie MeSH
- chelátory MeSH
- glutamin metabolismus MeSH
- histamin MeSH
- histidin * škodlivé účinky chemie fyziologie terapeutické užití MeSH
- hypertrofie etiologie MeSH
- játra metabolismus patologie MeSH
- kontraindikace MeSH
- lidé MeSH
- metabolický syndrom terapie MeSH
- nemoci jater metabolismus MeSH
- nemoci nervového systému terapie MeSH
- potravní doplňky * MeSH
- roztoky pro uchovávání orgánů MeSH
- scavengery volných radikálů MeSH
- větvené aminokyseliny metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
In this study we attempted to characterize amino acids properties and their possible interactions with the metal ions. In the first part of this study we described the structure of amino acids, its biochemical properties and its role in organism. In the next and the most important part we summarized accessible information about the metals and heavy metals which can form a bond with amino acids. Especially the heavy metals could have really important role in the process of metabolisms of amino acids, but this role is still unknown.
